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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE277096 CD4+/CD8+ selection of anti-AML engager T cells alters their manufacturing environment, transcriptome, and functional phenotype September 12, 2025Contributors : Natalie J Holl ; Adam Fearnow ; Ilias Christodoulou ; Stamatia C Vorri ; Ruyan Rahnama ; Jun Choe ; Alokesh Ghosal ; Weng-Ian Ng ; Hannah W Song ; Ravi Varadhan ; Vinay Vyas ; Challice L BonifantSeries Type : Expression profiling by high throughput sequencingOrganism : Immunotherapies have shown efficacy against some cancers. Despite initial c […]
- GSE213184 CRISPRi screen to identify genes critical for the shear stress activation of non-adherent monocyte. September 12, 2025Contributors : Vishal Nigam ; Lance HsiehSeries Type : OtherOrganism : Circulating blood cells, such as leukocytes, experience significant hemodynamic stresses. These stresses are significantly higher when a patient requires mechanical support of the circulation, such as cardiopulmonary bypass. To identify molecular mechanisms by which cells sense these stre […]
- GSE307678 Plasma-derived exosomal miRNA profiling in dengue patients with and without warning signs September 12, 2025Contributors : Gokulakannan Venkatesan ; Wan Rahman ; Wan Shahidan ; Gnanasoundari Gokulakannan ; Nik KamalSeries Type : Non-coding RNA profiling by arrayOrganism : Dengue virus infection is recognized as one of the most important mosquitos borne human diseases of the 21st century. It can manifest clinically as a moderate febrile illness, or a severe life-th […]
- GSE213287 Role of MicroRNA-30a on Pulmonary Angiogenesis and Alveolarization in neonatal hyperoxia September 12, 2025Contributors : Krithika Lingappan ; Cristian CoarfaSeries Type : Expression profiling by high throughput sequencingOrganism : miR-30a -/- neonatal mice were exposed to hyperoxia [95% FiO2, postnatal day (PND) 1-5] or room air before being euthanized on PND 21.
- GSE213285 Craters on the melanoma surface serve as hubs for CD8+ T cells [RNA-Seq] September 12, 2025Contributors : Aya Ludin ; Georgia L StirtzSeries Type : Expression profiling by high throughput sequencingOrganism : Immune cell interactions with tumor cells are critical for cancer therapeutic response, but it is unclear whether T cells take a direct or random path into a tumor. We performed 3D, long-term imaging of zebrafish melanomas and found that CD8+ […]
- GSE275067 Deep longitudinal immune profiling reveals reprogramming of memory T cells that links to B cell dysregulation with age. September 12, 2025Contributors : Qiuyu Gong ; Emma L Kuan ; Mehul Sharma ; Marla C Glass ; Aishwarya Chander ; Mansi Singh ; Lucas T Graybuck ; Zachary J Thomson ; Christian M LaFrance ; Samir R Zaim ; Tao Peng ; Lauren Y Okada ; Palak C Genge ; Cate Speake ; Thomas F Bumol ; Ananda W Goldrath ; Troy R Torgerson ; Xiao-jun Li ; Peter J Skene ; Jane H Buckner ; Claire E Gustaf […]
- GSE271896 Deep longitudinal immune profiling reveals reprogramming of memory T cells that links to B cell dysregulation with age September 12, 2025Contributors : Qiuyu Gong ; Emma L Kuan ; Mehul Sharma ; Marla C Glass ; Aishwarya Chander ; Mansi Singh ; Lucas T Graybuck ; Zachary J Thomson ; Christian M LaFrance ; Samir R Zaim ; Tao Peng ; Lauren Y Okada ; Palak C Genge ; Cate Speake ; Thomas F Bumol ; Ananda W Goldrath ; Troy R Torgerson ; Xiao-jun Li ; Peter J Skene ; Jane H Buckner ; Claire E Gustaf […]
- GSE291929 Cell type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis stem cells September 12, 2025Contributors : Jennifer A Urban ; Daniel Ringwalt ; John M Urban ; Wingel Xue ; Ryan Gleason ; Keji Zhao ; Xin ChenSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Stem cells have the unique ability to self-renew and differentiate into specialized cell types. […]
- GSE291715 Cell type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis stem cells [Repli-seq] September 12, 2025Contributors : Jennifer A Urban ; Daniel Ringwalt ; John M Urban ; Wingel Xue ; Ryan Gleason ; Keji Zhao ; Xin ChenSeries Type : OtherOrganism : Stem cells have the unique ability to self-renew and differentiate into specialized cell types. Among the many factors influencing cell fate, epigenetic mechanisms, like histones, play a crucial role in regulating g […]
- GSE298087 Wdr4-mediated m7G modification on let-7 miRNA to Maintain Steady-State Ribosome Biogenesis for Intestinal Homeostasis September 12, 2025Contributors : Kreeti Kajal ; Elham Rastegari ; Wen-Der Wang ; Jian-Chiuan Li ; Chun-Hong Chen ; Wan-Hsuan Chou ; Wei-Chiao Chang ; Tzu-Yang Lin ; Kevin Tsai ; Tsai-Ming Lu ; Kartik Venkatachalam ; Hwei-Jan HsuSeries Type : Expression profiling by high throughput sequencingOrganism : Ribosome biogenesis is recently known to control stem cell fate, while its […]
- GSE295848 Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system September 12, 2025Contributors : Ke Tan ; Elena O Gracheva ; Sviatoslav N BagriantsevSeries Type : Expression profiling by high throughput sequencingOrganism : Mammals and reptiles possess a sophisticated somatosensory system for precise tactile discrimination via mechanosensory end-organs, such as Meissner and Pacinian corpuscles, and others. These structures detect sustaine […]
- GSE298501 Single nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity [snRNA-seq] September 12, 2025Contributors : Karoline Hack ; Ulrich SchüllerSeries Type : Expression profiling by high throughput sequencingOrganism : The two most prevalent types of spinal ependymal tumors are myxopapillary ependymomas (MPE) and spinal ependymomas (SP-EPN). Based on molecular data from bulk tumor samples, we previously identified clinically relevant subtypes with poor ( […]
- GSE298506 Single nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity [methylation] September 12, 2025Contributors : Hack Karoline ; Schüller UlrichSeries Type : Methylation profiling by genome tiling arrayOrganism : The two most prevalent types of spinal ependymal tumors are myxopapillary ependymomas (MPE) and spinal ependymomas (SP-EPN). Based on molecular data from bulk tumor samples, we previously identified clinically relevant subtypes with poor (MPE-A; […]
- GSE306853 Perturb-seq experiment on patient-derived cancer-associated fibroblast in vitro cell line models from pancreatic ductal adenocarcinoma September 12, 2025Contributors : Elysia Saputra ; Shamsudheen K Vellarikkal ; Lixia Li ; Hong Sun ; Suchitra Natarajan ; Alex M Tamburino ; Xin Yu ; Aleksandra K OlowSeries Type : Expression profiling by high throughput sequencingOrganism : Cancer-associated fibroblasts (CAFs) are sought after as potential therapeutic targets due to their plethora of pro- and antitumorigenic […]
- GSE277034 Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression September 12, 2025Series Type : Expression profiling by high throughput sequencingOrganism : The goal of the scRNAseq study was to identify developmental defects and differential gene expression in MFRN1 mutant d3 zebrafish embryos