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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE288155 Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids [RNAseq_time] September 8, 2025Contributors : Alexandre Mayran ; Lucille Lopez-Delisle ; Jérôme Ng Wong ; Judith Pineau ; Thomas Gregor ; Denis DubouleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUnderstanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, […]
- GSE279996 The multimodal transcriptional response of denervated skeletal muscle involves alterations in cholesterol homeostasis impacting muscle size September 8, 2025Contributors : Cristofer Calvo ; Casey O Swoboda ; Fabian M Morales ; Siddhant Nagar ; Michael J Petrany ; Chengyi Sun ; Hima B Durumunla ; Mattia Quattrocelli ; Douglas P MillaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe development and maintenance of the neuromuscular junction (NMJ) requires reciprocal signals […]
- GSE288376 Differential chromatin accessibility, gene expression and mRNA splicing between developing cochlear inner and outer hair cells [ATAC-Seq] September 8, 2025Contributors : Chuan Zhi Foo ; Anne Duggan ; Elizabeth T Bartom ; Litao Tao ; Jaime García-AñoverosSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe mammalian cochlea has two types of low abundance and highly specialized inner (IHC) and outer (OHC) mechanosensory hair cells. Their malfunction or death ar […]
- GSE288158 Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids September 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE145925 m6A IP sequencing analysis of m6A mRNA methylation regulation by YTHDF2 in keratinocytes September 8, 2025Contributors : Jiangbo Wei ; Seungwon YangSeries Type : OtherOrganism : Homo sapiensN6-methyladenosine (m6A) RNA methylation is the most abundant internal chemical modifications in eukaryotic messenger RNA (mRNA) as well as long non-coding RNA (lncRNA). Recently, m6A RNA methylation research was revived by the discovery of the fat mass- and obesity-associate […]
- GSE307320 Dog aortic endothelial cells as a model for studying the effects of nanoplastics September 8, 2025Contributors : Giuseppina Basini ; Martina Tambassi ; Simona Bussolati ; Francesca Grasselli ; Anna Scalori ; Erika Scaltriti ; Stefano Grolli ; Roberto Ramoni ; Melissa BerniSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisA growing concern regards plastic fragments mainly nanoplastics (NP). The present study […]
- GSE306969 Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus [RNA-Seq neurosphere] September 8, 2025Contributors : Lei Tao ; Long Teng ; Ligong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIron transporters are essential for maintaining cellular iron homeostasis. Among them, SLC22A17 mediates lipocalin-2 (LCN-2)-dependent iron transport, but its precise role in the brain remains unclear. Here, we show that Slc2 […]
- GSE263263 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes : CUT&Tag 1 September 8, 2025Contributors : Shunsuke Ito ; Takashi Kondo ; Takaho A Endo ; Hakurihi KosekiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPolycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms t […]
- GSE307179 Polystyrene MiPolystyrene Microplastics Induce Radiotherapy Resistance in Lung Cancer by Suppressing Ferroptosis through NF-κB Activationcroplastics Induce Radiotherapy Resistance in Lung Cancer by Suppressing Ferroptosis through NF-κB Activation September 8, 2025Contributors : Heng Zhou ; Yali Liu ; Yanxian Ren ; Ningzu Jiang ; Ao Sun ; Song Wu ; Tianyi Zhu ; Jin Li ; Chenghao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAims: Polystyrene microplastics (PS-MPs) are emerging environmental pollutants, but their impact on lung cancer treatment remains unclear. This study inve […]
- GSE307173 RNA-seq profiling of cervical tissue in a lipopolysaccharide-induced rat model of preterm birth September 8, 2025Contributors : Yijie Gao ; Ming Liu ; Ping Ru ; Lulu Meng ; Yun Liu ; Xiaotian NI ; Ling WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis study aims to investigate the alterations in cervical remodeling and the underlying molecular mechanisms in a lipopolysaccharide (LPS)-induced rat model of preterm birth […]
- GSE307221 HIF1A regulated genes in MCF10A cells after treatment with Oncostatin M or control ligands September 8, 2025Contributors : Ian C McLean ; Sean M Gross ; Tiera Liby ; Mark A Dane ; Daniel S Derrick ; Laura M HeiserSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe employed a single-cell RNA sequencing approach to study the role of Oncostatin M (OSM) in inducing collective cell migration in MCF10A cells and its upregula […]
- GSE307237 SUMO E3 ligase SIZ1 sustains nuclear condensate-mediated immune activation in plants September 8, 2025Contributors : Yangnan Gu ; Min Jia ; Enrico CalvaneseSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaSIZ1, a major plant SUMO E3 ligase, has diverse roles in development and immunity. Although loss-of-function studies have positioned SIZ1 as a negative immune regulator, the pleiotropic effects of its broad subs […]
- GSE307247 Deciphering the cis-regulatory code of alternative splicing in human cell lines September 8, 2025Contributors : Samantha E Koplik ; Angela M Yu ; Georg SeeligSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAlternative splicing (AS) is a key mechanism of gene expression diversity, and dysregulation of AS is implicated in many human diseases. Identifying variants that disrupt splicing and characterizing their […]
- GSE276496 Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development. September 8, 2025Contributors : Xinjian D He ; Louis F Taylor ; Jesse MagerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian preimplantation development culminates in the formation of a blastocyst which undergoes extensive gene expression regulation to successfully implant into the maternal endometrium. Zinc-finger HIT domain-co […]
- GSE306966 Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus [RNA-Seq hippocampus] September 8, 2025Contributors : Lei Tao ; Long Teng ; Ligong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIron transporters are essential for maintaining cellular iron homeostasis. Among them, SLC22A17 mediates lipocalin-2 (LCN-2)-dependent iron transport, but its precise role in the brain remains unclear. Here, we show that Slc2 […]