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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE276571 MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors September 5, 2025Contributors : Si Chen ; Shuyue Wang ; Rongjie Fu ; Han Xu ; Weiyi Peng ; Yue LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Hyperactivated protein arginine methyltransferases (PRMTs) are implicated in human cancers. Inhibiting tumor intrinsic PRMT5 was reported to potentiate antitumor immune responses, h […]
- GSE276463 On the way to elucidate the effects of cannabidiol (CBD) on living organisms - assessment of changes in the global transcription profile of the hippocampus in a mouse model September 5, 2025Contributors : Jakub Żurowski ; Sebastian Sawicki ; Ewa Ocłoń ; Tomasz Szmatoła ; Igor Jasielczuk ; Karolina Mizera-Szpilka ; Artur GurgulSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCannabidiol (CBD) is a phytocannabinoid that has anti-inflammatory, immunomodulatory, antioxidant, anxiolytic, antipsychotic, and antic […]
- GSE307286 Combining brigatinib with mTOR inhibition to effectively treat NF2-SWN-associated and sporadic NF2-deficient meningiomas September 5, 2025Contributors : Long-Sheng Chang ; Janet L Oblinger ; Lai-Man Natalie Wu ; Cecelia Miller ; Sarah S BurnsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously generated an orthotopic, NF2-deficient meningioma model using the luciferase-expressing Ben-Men-1 cell line established from a sporadic tumor and identifie […]
- GSE279901 Gene expression profile at single cell level of endothelial cells (ECs) from the WT and Apoa1bp-/- mice adductors with femoral artery ligation (FAL) injury September 5, 2025Contributors : Yong P Bai ; Long H FangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEstablishment of collateral circulation (CC) is crucial for the treatment of ischemic disease, such as peripheral artery disease (PAD). We performed single-cell transcriptomic analysis to explore the cellular mechanism underlying CC. […]
- GSE246346 Deciphering histone mark-specific fine-scale chromatin organization at high resolution with Micro-C-ChIP September 5, 2025Contributors : Mariia Metelova ; Nils KrietensteinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusThe regulation of cell-type-specific transcription programs is a highly controlled and complex process that needs to be fully understood. The gene regulation is often influenced by dista […]
- GSE212868 Murine kidneys： WT Models vs METTL3-cKO Models September 5, 2025Contributors : Zongyao Hao ; Bingbing HouSeries Type : OtherOrganism : Mus musculusMeRIP and RNA Epitranscriptomic Microarray analysis in kidneys of conditional knockout (cKO) METTL3 mice and wild type mice following glyoxylate-induced CaOx nephrocalcinosis.In METTL3-cKO mice, METTL3 subjected the specific absence from renal tubular epithelial cells. Goal wa […]
- GSE305828 IL-1β priming triggers an adaptive stress response that enhances pancreatic β-cell resilience to subsequent cytotoxic inflammatory insult September 5, 2025Contributors : Carolina Sétula ; Ingrid Pensado Evans ; Andrea Scelza Figueredo ; Miranda S Orellano ; Ignacio Rodríguez-Valero ; Eduardo Spinedi ; Raghavendra G Mirmira ; Luz Andreone ; Marcelo J PeroneSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusIn this study, we explored the role of IL-1β-mediated hormesis in […]
- GSE274480 scRNAseq of mouse proliferative vitreoretinopathy September 5, 2025Contributors : Mengyu Liao ; Zhisheng Ye ; Xiaohong Wang ; Hua YanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed single cell transcriptional profiling of mouse proliferative vitreoretinopathy (PVR), to decipher the molecular mechanisms underlying mouse PVR fibrogenesis. In this study, through combination o […]
- GSE306629 Bulk RNA sequencing for various tissues using SENCR-BAC transgenic mice September 5, 2025Contributors : Qing Lyu ; Yuyan Lyu ; Songmao WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSENCR is a vascular-restricted long noncoding RNA specifically expressed in humans. To investigate its biological role in vivo, we generated a transgenic mouse line by introducing a ~220 kb genomic locus encompassing SENCR […]
- GSE306049 Atf3 Deficiency Promotes Mesodermal Commitment and Enhances Endothelial Differentiation in Embryonic Stem Cells September 5, 2025Contributors : Zongyue Jiang ; Lide Su ; Cuiting Chen ; Ronghai He ; Lili Jiang ; Yanyan Shu ; Dandan Dai ; Man Wu ; Ailing Guo ; Jianlei Liu ; Suhuan Liu ; Zonghong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIschemic disease has become a major threat to global health, and endothelial cells (ECs) damage is close […]
- GSE306835 Adipose-Specific GHR Knockout Confers Multidimensional Anti-Aging Advantages via Adipose Tissue Remodeling and Enhanced Metabolic Elasticity September 5, 2025Contributors : Rui Ma ; Li-yuan Ran ; Jin-yang Geng ; Jie Liu ; Bin Liang ; Li Qiang ; Ying-jie WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe global growth hormone receptor knockout (GHR-/-) extends lifespan but causes adverse effects. Adipose tissue serves as a critical target organ for growth hormone (GH). Rec […]
- GSE306837 Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development September 5, 2025Contributors : Sara Jiménez ; Florence Blot ; Aline Meunier ; Rishabh Kapoor ; Valérie Schreiber ; Colette Giethlen ; Sabitri Ghimire ; Maxime Mahe ; Nacho Molina ; Adèle De Arcangelis ; Gérard GradwohlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusEnteroendocrine cells (EECs) are rare intestinal epithel […]
- GSE307031 Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging September 5, 2025Contributors : Pin Lyu ; Isabella Palazzo ; Yang Jin ; Leah J Campbell ; Clayton P Santiago ; Rogger P Carmen-Orozco ; Thanh Hoang ; Jared A Tangemen ; Alexander D Park ; Shawn H Yang ; Jianming Shao ; Rui Chen ; David Hyde ; Jiang Qian ; Seth BlackshawSeries Type : OtherOrganism : Mus musculusWe performed integrated single-cell RNA- and ATAC-Seq analyses of […]
- GSE276420 Performing RNA sequencing on wild-type and Arrb2 knockout mouse primary astrocytes within the MPP+ model September 5, 2025Contributors : Xin Sun ; Yueping Wang ; Yajie Zhang ; Ruixue Han ; Min Wang ; Jing Zhang ; Ting Sun ; Yang Liu ; Gang Hu ; Lei Cao ; Ming LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe aimed to investigate the potential mechanism underlying the phenotypic transformation of astrocytes mediated by β-arrestin2. Prima […]
- GSE304173 Single-cell glycome and transcriptome profiling uncovers the glycan signature of each cell subpopulation of human iPSC-derived neurons September 5, 2025Contributors : Haruki Odaka ; Hiroaki TatenoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman induced pluripotent stem cells (iPSC)-derived cells are often heterogeneous, posing challenges for disease modeling and cell therapy. We previously developed single-cell glycan and RNA sequencing (scGR-seq) to analyze the g […]