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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275921 Differential gene expression in bone marrow derived macrophages during Candida albicans infection August 22, 2025Contributors : Michael McFadden ; Teresa O'Meara ; Mary O'RiordanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere, we measure early changes in gene expression in macrophages after Candida albicans infection for 4 hours.
- GSE282342 Aged muscle stem cells epigenetically drive the expansion of mesenchymal progenitors August 22, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE281168 Shikonin inhibits the malignant progression of triple-negative breast cancer August 22, 2025Contributors : Wenna Liu ; Ying LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the underlying mechanism of shikonin in TNBC, we performed high-throughput sequencing to screen differentially expressed genes 24 hours after shikonin treatment
- GSE157524 Unbiased identification of nanoparticle cell uptake mechanism via a genome-wide CRISPR/Cas9 knockout screen August 22, 2025Contributors : Eric L Van Nostrand ; Sarah A Barnhill ; Alexander A Shishkin ; David A Nelles ; Eric Byeon ; Thai Nguyen ; Yiu-Chueng E Wong ; Nathan C Gianneschi ; Gene W YeoSeries Type : OtherOrganism : Homo sapiensA major bottleneck in nanocarrier and macromolecule development for therapeutic delivery is our limited understanding of the processes involved […]
- GSE285384 Regulation of Feather Length: FGF/IGF Signaling and NOTCH/YAP Modulation of Progenitor Cell Topology [scRNA-seq] August 22, 2025Contributors : Ping Wu ; Federico Bocci ; Qing Nie ; Cheng-Ming ChuongSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusThe regulation of organ size is a fundamental biological question. This study investigates how feather length is regulated in chickens. We found collar bulge stem cell zones vary in size: main sickle […]
- GSE268288 CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of the maternal-to-zygotic transition in teleosts [RNA maternal screening] August 22, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe Maternal-to-Zygotic transition (MZT) is a reprograming process encompassing zygotic genome activation (ZGA) and the clearance of maternally-provided mRNAs. While some factors regulating MZT have been identified, there are thousands of maternal RNAs whose function has no […]
- GSE254960 Transcriptional profiling of colon cancer tumors in mice with Trim21 gene Knock out August 22, 2025Contributors : Hua Wu ; Xiaoqin YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the biological function Trim21 in the colon cancer, we compared the gene expression profiles of colon tumor tissues from Trim21 +/+ and Trim21 -/- mice treated with the carcinogen azoxymethane (AOM) and the proinflammatory […]
- GSE306079 Fibroblast growth factors induce preadipocyte UCP1 expression and imprint on post-differentiation white and brown adipocyte function August 22, 2025Contributors : Katharina Kuellmer ; Tobias FrommeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObjective: The presence of uncoupling protein 1 (Ucp1) is a hallmark of thermogenic adipocytes and enables heat production by dissipating energy from mitochondrial proton motive force as heat. The purpose of its recently dis […]
- GSE306035 scRNA-Seq of immune populations from nasal mucosa and lungs of C57BL/6 mice and BLT1 receptor deficient mice infected intranasally with MCMV K181 strain August 22, 2025Contributors : Lauren Springer ; Christopher SnyderSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe used a single cell sequencing approach using 10x Genomics scRNAseq to understand the transcriptional differences between immune populations from MCMV infected wildtype C57BL/6 mice and BLT1-/- mice. IFNy produci […]
- GSE306102 Long noncoding RNA-dependent control of Myc transcriptional bursting [HiC] August 22, 2025Contributors : Qiao Li ; Corinne Dilsavor ; Valid Gahramanov ; Erin Floyd ; Jane Ding ; Justin Glynn ; Ioannis Chiotakakos ; Christiane E Olivero ; Jesse R Zamudio ; Nadya DimitrovaSeries Type : OtherOrganism : Mus musculusGenes are transcribed in short periods of activity, called bursts. Bursts are initiated by enhancer-promoter contacts and dynamically con […]
- GSE306101 Long noncoding RNA-dependent control of Myc transcriptional bursting [ATAC-Seq] August 22, 2025Contributors : Qiao Li ; Corinne Dilsavor ; Valid Gahramanov ; Erin Floyd ; Jane Ding ; Justin Glynn ; Ioannis Chiotakakos ; Christiane E Olivero ; Jesse R Zamudio ; Nadya DimitrovaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusGenes are transcribed in short periods of activity, called bursts. Bursts are […]
- GSE306107 Long noncoding RNA-dependent control of Myc transcriptional bursting [RNA-Seq] August 22, 2025Contributors : Qiao Li ; Corinne Dilsavor ; Valid Gahramanov ; Erin Floyd ; Jane Ding ; Justin Glynn ; Ioannis Chiotakakos ; Christiane E Olivero ; Jesse R Zamudio ; Nadya DimitrovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenes are transcribed in short periods of activity, called bursts. Bursts are initiated by e […]
- GSE306119 WNT8B and WNT9B signaling promote the survival of dormant HGSOC cells through a non-canonical pathway that regulates cancer stem cell phenotypes. August 22, 2025Contributors : Komila Zakirova ; Fred DickSeries Type : OtherOrganism : Homo sapiensCancer cell dormancy and the resultant resistance to conventional therapies present significant challenges for the successful treatment of high-grade serous ovarian cancer (HGSOC). We used genome wide and specialized sgRNA libraries in CRISPR-based screens to identify critica […]
- GSE306159 Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function August 22, 2025Contributors : Katharina Kuellmer ; Tobias FrommeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe presence of uncoupling protein 1 (UCP1) is a hallmark of thermogenic adipocytes and enables heat production by dissipating energy from mitochondrial proton motive force as heat. The purpose of its recently discovered pre […]
- GSE273784 tRNA-overlapping long non-coding RNAs repress codon-biased genes in trans August 22, 2025Contributors : Sameen Ahmed ; Jacob L Fine ; Jordan J Chalmers ; Katerina Kiriakopulos ; Lindsay A Clarke ; Carla Casanova Suárez ; Katty Soleimanpour ; Winona Oliveros ; Kate Delfosse ; Milad Mokhtaridoost ; Cassandra J Wong ; Anne-Claude Gingras ; Brian Ciruna ; Marc Fabian ; Benjamin J Blencowe ; Philipp G MaassSeries Type : Expression profiling by high t […]