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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE212451 EZH2 reads DNA 6mA to regulate survival and drug resistance of human head and neck squamous carcinoma by suppressing RIOX2-CDKN1A-NRF2 signaling axis [RNA-seq] August 18, 2025Contributor : Chengli GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed short hairpin RNA (shRNA)-mediated knockdown (KD) experiments to abrogate ALKBH1 expression.To comprehensively understand the underlying mechanism of ALKBH1 in HNSCC, we performed RNA-seq assay and profiled gene expression alteration o […]
- GSE212400 EZH2 reads DNA 6mA to regulate survival and drug resistance of human head and neck squamous carcinoma by suppressing RIOX2-CDKN1A-NRF2 signaling axis [ChIP-MeDIP-seq] August 18, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Homo sapienswe attempted to comprehensively assess whether EZH2 recognizes 6mA modification at the global level.We first performed chromatin immunoprecipitation following sequencing (ChIP-seq) in human HNSCCs using an […]
- GSE248297 Liver RNA-seq from male C57Bl/6J on a ketogenic diet August 18, 2025Contributors : Molly Gallop ; Amandine ChaixSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA ketogenic diet (KD) is a very low-carbohydrate, very high-fat diet recently proposed to treat obesity and type 2 diabetes. While KD grows in popularity, its effects on metabolic health are understudied. (here) We show that, whi […]
- GSE236259 Macrophage Regnase-3 limits tissue inflammation and injury via alternative splicing of pre-mRNA August 18, 2025Contributors : Chenyu Li ; Hans-Joachim AndersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-binding proteins regulate posttranscriptional gene translation regulate but little is known about the cell type-specific functions of Regnase3. Here, we characterized the role of Regnase3 in macrophages using RankCre-Regnas […]
- GSE275286 Transcriptional analysis of dendritic cells upon TLR stimulation reveals an immunosuppressive profile (N279 scRNA-Seq) August 18, 2025Contributors : Ling Wang ; Xiaoli Liu ; Cliff Y YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDendritic cells (DCs) simultaneously prime and dampen the immune response. The transcriptional program that regulates immunosuppression in DCs is currently unknown. Here we identified ETS homologous factor as a key transc […]
- GSE275278 Transplantation-induced reprogramming determines successful hepatocyte engraftment August 18, 2025Contributors : Zhen Sun ; Baihua Wu ; Shujie Bao ; Ludi ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWhile demonstrated safety and efficacy in treating liver diseases, hepatocyte-based therapy faces the challenge of limited engraftment of transplanted hepatocytes (Tx-Heps) in clinical settings, ak […]
- GSE303501 Computationally resolved neuroprogenitor cell biomarkers associate with human disorders August 18, 2025Contributor : William ChoiSeries Type : Expression profiling by arrayOrganism : Mus musculusAdult hippocampal neurogenesis, relies on a rare population of neural stem and progenitor cells (NPCs) within the dentate gyrus complex microenvironment. Discovering the specific genes that define these cells is vital yet challenging due to overlapping expression patt […]
- GSE278413 Nanopore RNAseq profiling of female wildtype or Malat1-/- naïve CD4+ T cells and in vitro differentiated Th2 cells for 2 days. August 18, 2025Contributors : Dimitris Lagos ; Mags GwynneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptomic profiling of Malat1-deficient and WT CD4+ T cells at Day 0 (naïve CD4+ T cells) and Day 2 post-induction of differentiation under Th2 conditions. Naive CD4+ T cells isolated from spleens and lymphnodes of female mic […]
- GSE305163 Functional, sustained recovery of hearing in Otoferlin-deficient mice using DB-OTO, a hair cell-specific AAV based dual vector gene therapy August 18, 2025Contributors : Yoojin Chung ; Seth D Koehler ; Sarah Cancelarich ; Tyler M Gibson ; Gabriela Pregernig ; Lars Becker ; Quynh-Anh Artinian ; Joseph W Goodliffe ; Ning Pan ; Tera Quigley ; Arun Senapati ; Peter G Slade ; Lillian M Smith ; Kathy S So ; Xichun Zhang ; Carleton E Corrales ; Peter Weber ; Lynn E Macdonald ; Brian Zambrowicz ; Aris N Economides ; C […]
- GSE304252 Synergistic effects of Ret coding and enhancer loss-of-function alleles cause progressive loss of inhibitory motor neurons in the enteric nervous system August 18, 2025Contributor : Sumantra ChatterjeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHirschsprung disease (HSCR) is a congenital enteric neuropathy caused by disrupted migration, proliferation, or differentiation of enteric neural crest-derived cells (ENCDCs), with pathogenic variants at the RET locus accounting for a major […]
- GSE305216 Decoding cellular stress states for toxicology using single-cell transcriptomics August 18, 2025Contributors : Brian N. Chorley ; Imran Shah ; Dennis J. EastburnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell transcriptomics (SCTr) offers a powerful platform for decoding the complexities of cellular stress responses to chemical exposures, capturing rare and transient subpopulations that can be obscured […]
- GSE305223 RNA sequencing analysis of embryos exposed to nanoplastics: effects on developmental and transcriptomic alteration August 18, 2025Contributors : Hyeong-Ju You ; Yu-Jin Jo ; Jeongwoo Kwon ; Seung-Bin Yoon ; Changsic Youn ; Yejin Kim ; Man-Jong Kang ; Ji-Su KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe increasing prevalence of nanoplastics (NPs) in the environment has raised concerns regarding their potential risks to ecosystems and human h […]
- GSE305284 Dads matter, too: The behavioural and neurogenomic effects of receiving paternal care [ATAC-Seq] August 18, 2025Contributors : Jason Keagy ; Alison M BellSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Gasterosteus aculeatusOffspring are often influenced by the care they receive from their parents. However, we know little about the underlying neurogenomic mechanisms. Using a half-sib design, threespine stickleback fish were eit […]
- GSE202149 Effect of G2E3 knockout and SUV39H2 knockout on gene expression and heterochromatin repeats DNA transcription in HeLa cells. August 18, 2025Contributors : Yuanyong Huang ; Quanlong Jiang ; Jing-Dong J Han ; Jiemin WongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the correlation between G2E3 and SUV39H2 in regulating gene expression and heterochromatin repeats DNA transcription, we generated G2E3 knockout HeLa cells line and SUV39H2 knockou […]
- GSE302570 Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome August 18, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding the genetic causes of diseases affecting pancreatic β cells and neurons can give insights into pathways essential for both cell types. Microcephaly, epilepsy and diabetes syndrome (MEDS) is a congenital disorder with two known aetiological genes, IER3IP1 and […]