Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE271990 Replication Stress Causes Mitotic Nuclear Envelope Reassembly Defect August 16, 2025
  Contributors : Guojun Ye ; Yide He ; Fuhai Liu ; Lin Deng ; Haoyue Zhang ; Kun SunSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensReplication stress, if not effectively and timely addressed, could result in DNA damage in mitosis. However, it remains unknown the relationship between mitotic DNA damage and o […]
• GSE255867 CHLORELLA, chloroplast-targeted long noncoding RNA, mediates the chloroplast functional transition during leaf lifespan through anterograde signaling pathway August 16, 2025
  Contributors : Myeong H Kang ; Juhyeon Lee ; Jinkwang Kim ; Hazara B Mohammad ; Jeehye Park ; Min-Sik Kim ; Jong-Chan Lee ; Pyung O LimSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThe transition of chloroplast function from biogenesis to degeneration upon leaf senescence is critical for a plant’s fitness, as […]
• GSE275018 Dynamic magneto-mechanical force in lysosomes instructs durable macrophage repolarization for antitumor immunity August 16, 2025
  Contributors : Yingze Li ; Mengge Zheng ; Zhenyan Zhu ; Yajuan Zhang ; Weiwei Yang ; Yichao Tang ; Haipeng Liu ; Chang Chen ; Yu ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMechanical forces are the emerging physical cue to regulate biochemical signals of immune cells for antitumor immunity. Here we used single […]
• GSE274805 Enterocyte dedifferentiation drives colonic regeneration following irradiation injury [scRNA-seq] August 16, 2025
  Contributors : Ye-guang Chen ; Mengxian Zhang ; Zeyu Zang ; Wanlu SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe intestinal epithelium consistently exposes to various injuries and exhibits remarkable regenerative capacity. Although small intestinal regeneration has been extensively investigated, the mechanisms […]
• GSE305521 Computational Tracking of Cell Origins Using CellSexID from Single-Cell Transcriptomes August 16, 2025
  Contributor : Qian LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset supports the validation and biological application of CellSexID, a computational method for inferring cell origin in sex-mismatched settings using single-cell RNA sequencing (scRNA-seq) data. CellSexID uses the expression of sex-linked gen […]
• GSE279572 Candida albicans (C. albicans) induce hypoxia response to promote colorectal cancer metastasis August 16, 2025
  Contributors : Wanqiu Wang ; Fanglei Gong ; Kun SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Here, we assessed the engagement of C. albicans, a common fungus, in CRC metastasis. Using a cell-fungi co-culture system, we foun […]
• GSE295729 Effect of overexpression different alleles C/G at locus rs149707223 of LINC02449 on gene expression of SK-N-SH cells(Human neuroblastoma cell line) August 16, 2025
  Contributor : Tengfei YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong non-coding RNA (LncRNA) is a significant epigenetic regulatory factor, and its allele-specific expression (ASE) may play an important role in mental disorders. Therefore, clarifying the relationship between allele-specific expression (ASE) of […]
• GSE182977 The human U5 snRNP assembly factor, AAR2, regulates gene expression dependent on the PRPF8 protein August 16, 2025
  Contributors : Marco Preussner ; Gert Weber ; Florian Heyd ; Markus C WahlSeries Type : Expression profiling by arrayOrganism : Homo sapiensSmall nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of snRNP core particles has been well characterized, the incorporation of snRNP-specific proteins and […]
• GSE302561 Comprehensive transcriptomic characterization of two melanoma cell lines with acquired dual resistance to BRAF and MEK inhibitors: toward understanding and reversing therapy resistance August 16, 2025
  Contributors : Tomasz Kujawa ; Tomasz KobielaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo elucidate the molecular mechanisms underlying acquired resistance to dual BRAF and MEK inhibition, we performed transcriptomic profiling of two melanoma cell lines, Hs294T and WM9, rendered resistant to the combination of vem […]
• GSE296023 Effect of overexpression different alleles C/G at locus rs149707223 of LINC02449 on gene expression in the mPFC of mice August 16, 2025
  Contributor : Tengfei YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLong non-coding RNA (LncRNA) is a significant epigenetic regulatory factor, and its allele-specific expression (ASE) may play an important role in mental disorders. Therefore, clarifying the relationship between allele-specific expression (ASE) of […]
• GSE304603 Mechanosensory PNECs drive airway inflammation via secretoneurin-Slc23a2 August 16, 2025
  Contributors : Masahiro Nemoto ; Masahiro Kiuchi ; Chiaki Iwamura ; Hiroyuki Yagyu ; Masaaki Seki ; Norie Hamaguchi ; Satoshi Yasuda ; Satoshi Ogasawara ; Kaori Tsuji ; Tsuguko Tomita ; Kanae Ohishi ; Takahisa Hishiya ; Atsushi Sasaki ; Kohei Kusakari ; Astushi Onodera ; Kazuhiro Furuhashi ; Keinosuke Hizuka ; Takeshi Kawasaki ; Motoko Y Kimura ; Shinichiro […]
• GSE305082 CUT&Tag-seq of H3k27me3 in vehicle and DOPAC-treated CD8+ T cells August 16, 2025
  Contributors : Penghu Han ; Jing Shen ; Shuzheng Chu ; Yatai Chen ; Shiyang Li ; Detian YuanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo investigate epigenetic alterations in vehicle and DOPAC-treated CD8+ T cells
• GSE305365 UV induced translation capacity is developmentaly regulated in fungi August 16, 2025
  Contributors : Quyen Hong ; Shira Milo ; Dibya Mukherjee ; Shay CovoSeries Type : Expression profiling by high throughput sequencingOrganism : Fusarium mangiferae ; Fusarium oxysporumIn fast-growing cells, most RNA molecules encode ribosomal subunits. During growth arrest caused by DNA damage, ribosome biogenesis is reduced because it is an highly energy dem […]
• GSE241004 FcRL3 expression defines specialized cytotoxic human memory T lymphocytes August 16, 2025
  Contributors : Niccolò Bianchi ; Silvia MonticelliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize the FcRL3+ T cell subset in memory helper CD4+, CD8+, and CD4+ regulatory lymphocytes, we performed RNA-sequencing analysis using T cells, separated by the expression of FcRL3, from the peripheral blood of 5 […]
• GSE295685 TNG260, a novel small-molecule CoREST inhibitor, sensitizes STK11-mutant tumors to anti-PD-1 immunotherapy August 16, 2025
  Contributors : Leanne G Ahronian ; Soumyadip Sahu ; Ayushi S Patel ; Kwok-Kin Wong ; Yuan HaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-small cell lung cancer (NSCLC) patients with loss of the tumor suppressor gene STK11 are resistant to immune checkpoint therapies like anti-PD-1. Our in-vivo CRISPR screen iden […]