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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273215 Hepatic progenitor cell-originated ductular reactionfacilitates liver fibrosis through activation of hedgehogsignaling August 1, 2025Contributors : Yonghong Hu ; Jian Wu ; Ping Liu ; Jiamei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: It is poorly understood what cellular types participate in ductular reaction (DR) andwhether DR facilitates recovery from injury or accelerates hepatic fibrosis. The aim of this study is to gaininsigh […]
- GSE271882 Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development [RNA-Seq] August 1, 2025Contributors : Yuhan Yang ; Logan Rivera ; Shaohai Fang ; Maryn Cavalier ; Ashley Suris ; Yubin Zhou ; Yun HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOur study suggested a direct link between maternal high-fat diet exposure and TET-mediated epigenetic regulation during heart development. Furthermore, we also u […]
- GSE275202 Transcriptomic Insights into Drought Tolerance Enhancement in Bread Wheat Induced by a Microalgae-based Biostimulant August 1, 2025Contributors : Francisco J Romero-Campero ; Mercedes García-González ; Christina Arvanitidou ; Marcos Ramos-González ; M E García-GómezSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum aestivumBread wheat (Triticum aestivum) is a staple food crucial for global caloric intake and food security. The current climate emergency d […]
- GSE274032 ATAC-Seq of sorted murine LT-HSCs segemented on intial CUX1 levels with and without CUX1 knockdown. August 1, 2025Contributors : Megan E McNerney ; Tanner C MartinezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) possess properties of both self-renewal and multipotent differentiation; however, the regulation of these opposing properties remains elusive. Using a novel reporter mouse, we […]
- GSE210457 Effect of Notch over-expression on murine liposarcoma cells August 1, 2025Contributors : Shihuan Kuang ; Pei-Chieh Tien ; Xiyue ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis RNA-seq analysis compares gene expression of a murine liposarcoma cell line with or without over-expression of Notch1 intracellular domain (NICD). The NICD overexpressing cell line (mLPS1) was derived from a c […]
- GSE275925 Maternal ancestry reveals cyclical aging of the mammary gland. August 1, 2025Contributor : Doris GermainSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusthe present provocative data that in addition to the expected progressive age-related involution, mammary gland aging can occur in a cyclical pattern and is dictated by maternal ancestry. In cyclical aging, mammary glands of 11 and 19 months old […]
- GSE303418 Selective inhibition of BRAF and CRAF sensitizes NF1-deficient malignant peripheral nerve sheath tumors to MEK inhibitors August 1, 2025Contributors : Angelina Vaseva ; Siyuan Zheng ; Funan HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Treatment for patients with malignant peripheral nerve sheath tumors (MPNST) is an unmet clinical need. Loss of NF1 in MPNST leads to hyperactivation of RAS oncoproteins, however little is known about rele […]
- GSE237672 Hepatic Dyrk1b regulates systemic glucose homeostasis [mouse liver] August 1, 2025Contributors : Lianju Li ; Ruixin Liu ; Jiqiu Wang ; Guang NingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusElucidation of the mechanisms controlling glucose homeostasis may deepen our understanding of the pathogenesis of T2DM and provide new therapeutic strategies for T2DM in the future. As reported, Dyrk1b is a ple […]
- GSE303695 Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice [RNA-seq] August 1, 2025Contributors : Qingran Kong ; Hao Li ; Qi Zhao ; Kefan Zheng ; Hongdi Cui ; Entong SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFatty acids are not only important as energy sources, but also playing crucial roles in maintaining cellular homeostasis.Inhibition of long-chain fatty acid β-oxidation (LCFAO) results i […]
- GSE303431 Transcriptomic Profiling of Scleroderma Monocytes Reveals Links with Cardiovascular Complications, Implicating Notch and Interferon Pathways August 1, 2025Contributors : Mehmed T Dinc ; Fatima El-Adili ; Justin K Lui ; Kripesh Subedi ; Michael York ; Marcin Trojanowski ; Giovanni Ligresti ; Robert Lafyatis ; Maria Trojanowska ; Andreea M BujorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjectives: Recent research has highlighted the critical role of monocytes and macr […]
- GSE303698 A human microphysiological model of afferent DRG nociceptor-spinal cord dorsal horn circuitry August 1, 2025Contributors : Frank Seipel ; Kevin Pollard ; Nisha R Iyer ; Randolph S Ashton ; Michael MooreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe generated single cell RNA-seq data to measure the transctiptional profiles of cervicothoracic human pluripotent stem cell-derived dorsal horn spheroids cultured together with h […]
- GSE303730 Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice_1 August 1, 2025Contributors : Rebecca S Hofford ; Jonathon P Sens ; Ava L Shipman ; Violet M Kimble ; Christina Coric ; Katherine R Meckel ; Drew D KiralySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdolescence is a critical period for the initiation of problematic drug use, which significantly increases the risk of developing subs […]
- GSE303733 Cerebellar Dysfunction in a Mouse Model of Childhood-Onset Manganese-Induced Dystonia Parkinsonism August 1, 2025Contributors : Alexander N Rodichkin ; Amanda M Brown ; Pavani Devabathini ; Jennifer L McGlothan ; Si Chen ; Ajith Pattammattel ; Yong S Chu ; Tao Lin ; Daniel D Pontow ; Karam Abilmouna ; Ritishka Kapoor ; Sarah E Hardin ; Yulia Pushkar ; Roy V Sillitoe ; Tomás R GuilarteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculu […]
- GSE263027 Highly-metastatic colorectal cancer cell released Nidogen 1-Enriched Extracellular Vesicles promote liver metastasis by activating hepatic stellate cells and forming the neutrophilextracellulartraps August 1, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe liver is frequently affected by metastasis in colorectal cancer patients; however, the precise interaction between the liver microenvironment and metastatic colorectal cancer cells remains elusive. Our study reveals that NID1, present in extracellular vesicles (EVs) de […]
- GSE303340 Hells protects mitochondrial integrity via Nr2f2 suppression during osteoclast differentiation August 1, 2025Contributors : Jueng Soo You ; Myoung Jun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteoclasts are bone-resorbing cells essential for skeletal remodeling. The chromatin remodeler Hells has been implicated in epigenetic regulation during cellular differentiation, but its role in osteoclastogenesis remains uncle […]