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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE264583 Non-cell autonomous tumor promotion in DICER1 cancer predisposition July 29, 2025Contributors : Randolph K Larson ; Mark E Hatley ; Hongjian JinSeries Type : Expression profiling by high throughput sequencing ; Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE255447 Single-cell gene expression profile of cultured mouse islet cells July 29, 2025Contributors : Jun Shirakawa ; Takahiro TsunoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDysregulated α-cell function contributes to the onset and progression of diabetes. Here, we report that the treatment with imeglimin, an anti-diabetes drug, prevents glucagon release and promotes α-to-β cell transdifferentiation […]
- GSE273471 Dimethyl itaconate alleviates Escherichia coli-induced endometritis by activating the guanosine-CXCL14 axis via increasing the abundance of Muribaculaceae July 29, 2025Contributors : Yuhang He ; Xufeng Xie ; Jiapei Cai ; Yongguo CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndometritis, a prevalent reproductive system disease with high incidence, leads to reproductive dysfunction and potential miscarriage in both humans and animals, impacting human health and the dairy industry, […]
- GSE273195 H2A.Z regulates memory CD8+ T cell recall response [4] July 29, 2025Contributors : Wei Liang ; Jiyu Ding ; Mingzhao ZhuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe rapid response of memory CD8+ T cells is crucial for the body's defense against infection and cancer. However, the mechanisms underlying memory recall responses remain unclear. Here we show that the […]
- GSE281900 SnoRNA:U3:9B is required for the activation of immune response genes in Drosophila melanogaster [ATAC-Seq] July 29, 2025Contributors : Jain Shruti ; Planells Jordi ; Regads Isabel ; Sinha Indranil ; Mannervik Mattias ; Visa NeusSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterSmall nucleolar RNAs (snoRNAs) are prevailing components of the chromatin-associated transcriptome. We have studied a specific chromatin-ass […]
- GSE280641 Effect of conditional SMC specific deletion of ADAR1 with constitutive deletion of RNA sensor MDA5 on mouse aortic single cell transcriptomic profile and effect on atherosclerosis July 29, 2025Contributor : Chad S WeldySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of dis […]
- GSE303433 Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [RNA-seq2] July 29, 2025Contributors : Maxime Gasnier ; Tanysha C Chen ; Swathi Yada ; Sowmya Sagiraju ; Yusuke Yoshikawa ; Stefano Perna ; Grace H Lim ; Bernett Lee ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent colorectal cancer (CRC) mouse models lack either colon specificity, limiting progression towards more advanced […]
- GSE288825 Evolution of a transplantable cancer by adaptation July 29, 2025Contributors : Ahmed Rokan ; Callum Hall ; Ariberto FassatiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe histocompatibility barrier prevents transmission of both normal and tumour cells between individuals 1, however clonally transmissible cancers in dogs, Tasmania devils and soft-shell clams can naturally transmi […]
- GSE303533 RNA sequencing of colonic ILC2s sorted from mice with DSS-induced colitis July 29, 2025Contributors : Yanyan Cui ; Qiuheng Tian ; Yatai Chen ; Shiyang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing was performed for ILC2s sorted from the colon of DSS- or H2O-treated C57BL/6 mice (n = 3 per group).
- GSE303434 Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [scRNA_seq] July 29, 2025Contributors : Maxime Gasnier ; Tanysha C Chen ; Swathi Yada ; Sowmya Sagiraju ; Yusuke Yoshikawa ; Stefano Perna ; Grace H Lim ; Bernett Lee ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent colorectal cancer (CRC) mouse models lack either colon specificity, limiting progression towards more advanced […]
- GSE303587 Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming July 29, 2025Contributors : Brittany A Lende-Dorn ; Kate E GallowaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCell states evolve through the combined activity of signaling pathways and gene regulatory networks. While transcription factors can direct cell fate, these factors rely on a cell state that is receptive to transitions […]
- GSE303651 H3K4 methylation-promoted transcriptional memory supports faithful zygotic genome activation and development July 29, 2025Contributors : Meghana S Oak ; Marco Stock ; Matthias Mezes ; Tobias Straub ; Antony M Hynes-Allen ; Jelle van den Ameele ; Ignasi Forne ; Andreas Ettinger ; Axel Imhof ; Antonio Scialdone ; Eva HörmansederSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Xenopus laevisAccurately established transcriptional programs are […]
- GSE303705 Spatial and temporal transcriptomic dynamics during intestinal regeneration July 29, 2025Contributors : Rachel Ofer ; Tyler Tran ; Ping He ; Xinyu Hu ; Qiu Xia ; Emmanual Zachariah ; Curtis Krier ; Ankit Saxena ; Jiekun Yang ; Michael VerziSeries Type : OtherOrganism : Mus musculusThe highly proliferative intestine is prone to damage, making it an ideal model for studying tissue regeneration. We performed spatial transcriptomics to characterize […]
- GSE210103 Transcriptome analysis of the binucleate ciliate Tetrahymena thermophila cells after mating and re-feeding. July 29, 2025Contributors : Linying Zhang ; Marcella Cervantes ; Simin PanSeries Type : Expression profiling by high throughput sequencingOrganism : Tetrahymena thermophilaDuring macronuclear development the five germline chromosomes undergo massive rearrangement, and the entire epigenome is remodeled from an obligate heterochromatic to obligate euchromatic state. The ~1 […]
- GSE303295 Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [RNA_seq] July 29, 2025Contributors : Maxime Gasnier ; Tanysha C Chen ; Swathi Yada ; Sowmya Sagiraju ; Yusuke Yoshikawa ; Stefano Perna ; Grace H Lim ; Bernett Lee ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCurrent colorectal cancer (CRC) mouse models lack either colon specificity, limiting progression towards more advanced […]