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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE262809 Hyperfunctioning MYC selectively redirects expression programs during human plasma cell differentiation July 22, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE268811 Early-life ketone body signaling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome [scRNA-seq] July 22, 2025Contributors : Fu J Lin ; Chung L Jiang ; Pei H LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInfants experience distinct ketogenesis during the preweaning period, but its physiological significance remains unclear. Here, we show that preweaning ketosis enhances beige fat biogenesis and improves metabolic health in […]
- GSE266618 Systematic discovery of CRISPR-boosted CAR T cell immunotherapies July 22, 2025Contributors : Paul Datlinger ; Eugenia V Pankevich ; Cosmas Arnold ; Daria Romanovskaia ; Christoph BockSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCAR T cell therapy has shown remarkable success in treating blood cancers, but CAR T cell dysfunction is a common cause of treatment failure. Here we present CELLFIE, a […]
- GSE275840 Gene expression profile of Cd45 positive cells in single cell level from KRASLSL.G12D/+P53LSL.R172H/+Pdx-Cre mice (KPC tumor mouse) model treated with stimulator of interferon genes (STING) and lymphotoxin-beta receptor (LTbR) agonist July 22, 2025Contributors : Junko Sawada ; Yasuhiro Kikuchi ; Fumiaki Kanamori ; Masanobu KomatsuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe combination treatment using STING and LTbR agonists improves the immune landscape in KPC tumor model. We used single-cell RNA sequence (scRNAseq) analysis to investigate the characteris […]
- GSE272223 Tumor suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction [ChIP-Seq] July 22, 2025Contributors : Zhenbo Tu ; Mahmoud A Bassal ; George W Bell ; Yanzhou Zhang ; Yi Hu ; Liza M Quintana ; Deeptha Gokul ; Daniel G Tenen ; Antoine E KarnoubSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTransposable elements play indispensable roles in human development, contributing significantly to plurip […]
- GSE241232 Loss of the C-terminus of p63 leads to an increased expression of extracellular matrix genes in keratinocytes due to a preferential binding of p63 to promoters July 22, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE227720 CRISPR-Cas9 base editing to render CaMKIIδ phosphoresistant improves survival and cardiac function in heart failure July 22, 2025Contributors : Simon Lebek ; Xurde M Caravia ; Francesco Chemello ; Wei Tan ; John McAnally ; Kenian Chen ; Lin Xu ; Ning Liu ; Rhonda Bassel-Duby ; Eric N OlsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe ablated the autophosphorylation site of CaMKIIδ (T287) using CRISPR-Cas9 adenine base editing technology.Ten- […]
- GSE303025 Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment July 22, 2025Contributors : Dalia Ibrahim ; Sarah Nersesian ; Barbara C VanderhydenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOvarian cancer is the most lethal gynecological malignancy. Deepening our knowledge of the interactions within the tumor microenvironment (TME) is important for discovering new targeted treatment strateg […]
- GSE302974 Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer July 22, 2025Contributors : Maryam Kohram ; Carolina Trenado-Yuste ; Molly C Brennan-Smith ; Evelyn S Navarro Salazar ; Pengfei Zhang ; Jasmine E Hao ; Xincheng Xu ; Bharvi Chavre ; William Oh ; Sherry X Zhang ; Susan E Leggett ; Rolf-Peter Ryseck ; Joshua D Rabinowitz ; Celeste M NelsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapie […]
- GSE303192 Transcriptomic analysis of ovarian cancer cells after drug administration and tRNA transfection at 10 and 24 hours July 22, 2025Contributors : Yuki Iimori ; Akio KanaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSLFN11 sensitizes cancer cells to DNA-damaging agents (DDAs) by cleaving and reducing tRNALeu(TAA). In this study, we investigated how the reduction of tRNALeu(TAA) contributes to cell death under Camptothecin (CPT) treatment. RNA-seq […]
- GSE303176 Early adipose tissue wasting in a preclinicl model of human lung cancer cachexia July 22, 2025Contributors : Deena B Snoke ; Jacob S Dearborn ; Devdoot Majumdar ; David J Seward ; Michael J TothSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer cachexia (CC), a syndrome of skeletal muscle and adipose wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC […]
- GSE303195 Effect of Lactobacillus crispatus on E. coli gene expression profiles in the gut of mice with inflammatory bowel disease. July 22, 2025Contributors : Jungtak Kim ; Karolina H Prazanowska ; Su Bin Lim ; Sun ParkSeries Type : OtherOrganism : Escherichia coli BL21(DE3)Gut microbiota modulation has emerged as a potential therapeutic and diagnostic approach for inflammatory bowel disease (IBD). We generated transcriptomic data by Record-seq, a method based on CRISPR-Cas system, that enables reco […]
- GSE303196 Gene expression profiles of E. coli in the gut of inflammatory bowel disease models. July 22, 2025Contributors : Jungtak Kim ; Karolina H Prazanowska ; Su Bin Lim ; Sun ParkSeries Type : OtherOrganism : Escherichia coli BL21(DE3)Gut microbiota modulation has emerged as a potential therapeutic and diagnostic approach for inflammatory bowel disease (IBD). We generated transcriptomic data by Record-seq, a method based on CRISPR-Cas system, that enables reco […]
- GSE303233 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [bulkTCRseq_Trilateral] July 22, 2025Contributors : Munetomo Takahashi ; Mikiya Tsunoda ; Hiroyasu Aoki ; Masaki Kurosu ; Haru Ogiwara ; Shigeyuki Shichino ; David Bending ; Shumpei Ishikawa ; James Thaventhiran ; Kouji Matsushima ; Satoshi UehaSeries Type : OtherOrganism : Mus musculusEffective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. […]
- GSE260868 Upregulated cholesterol biosynthesis facilitates the survival of methylation-retaining AML cells following decitabine treatment. [scTEM-Seq] July 22, 2025Contributors : Danielle R Bond ; Sean M Burnard ; Kumar Uddipto ; Kooper V Huntreated ; Brooke Harvey ; Charley Lawlor-O’Neill ; Ellise R Roper ; Sam Humphries ; Luiza Steffens Reinhardt ; Heather Murray ; Nikola Bowden ; Anoop K Enjeti ; Nicole M Verrills ; Carlos Riveros ; Kim-Anh Lê Cao ; Heather J LeeSeries Type : OtherOrganism : Homo sapiensDNA hypometh […]