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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE269912 In Vitro Validation of DNA-Diffusion and Control Sequences within the AXIN2 Locus [mRNA] July 13, 2025Contributors : L F DaSilva ; Simon Senan ; J F Kribelbauer ; GueHo Hwang ; Deplanke Bart ; Pinello LucaSeries Type : OtherOrganism : Homo sapiensDNA-Diffusion is a novel generative approach leveraging diffusion probabilistic models for the design of cell type-specific DNA regulatory sequences. To evaluate the capacity of DNA-Diffusion sequences to endogenous […]
- GSE267992 Mutant GFAP alters lineage commitment of neural organoids July 13, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE269921 In Vitro Validation of DNA-Diffusion and Control Sequences within the AXIN2 Locus [nanopore_plasmid] July 13, 2025Contributors : L F DaSilva ; Simon Senan ; J F Kribelbauer ; GueHo Hwang ; Deplanke Bart ; Pinello LucaSeries Type : OtherOrganism : synthetic constructDNA-Diffusion is a novel generative approach leveraging diffusion probabilistic models for the design of cell type-specific DNA regulatory sequences. To evaluate the capacity of DNA-Diffusion sequences to end […]
- GSE269915 In Vitro Validation of DNA-Diffusion and Control Sequences within the AXIN2 Locus [gRNA] July 13, 2025Contributors : L F DaSilva ; Simon Senan ; J F Kribelbauer ; GueHo Hwang ; Deplanke Bart ; Pinello LucaSeries Type : OtherOrganism : Homo sapiensDNA-Diffusion is a novel generative approach leveraging diffusion probabilistic models for the design of cell type-specific DNA regulatory sequences. To evaluate the capacity of DNA-Diffusion sequences to endogenous […]
- GSE302105 Repurposing Zafirlukast Confers Renal Protection in Ischemia-Reperfusion Injury via Suppressing Macrophage METosis July 13, 2025Contributors : Xiaochun Ye ; Meiyun Wen ; Yumei Huang ; Ruofang Zheng ; Ping Wang ; Ran Chen ; Longwei ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTacrolimus is widely used to prevent post-transplant acute kidney injury (AKI) but causes severe toxicities (e.g., nephrotoxicity, hyperglycemia). We repurposed zafir […]
- GSE276834 ATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (RNA) July 13, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlpha-thalassemia X-linked intellectual disability syndrome (ATR-X) is caused by mutations in the ATRX gene, which plays a pivotal role in heterochromatin integrity. In this study, we uncover a novel mechanism by which ATRX influences fate of human neural progenitor cells […]
- GSE279483 Transcriptome-proteome profiling in Burkholderia thailandensis during the transition from exponential to stationary phase July 13, 2025Contributors : Ahmed Al-Tohamy ; Anne GroveSeries Type : Expression profiling by high throughput sequencingOrganism : Burkholderia thailandensisBurkholderia thailandensis is closely related to highly pathogenic Burkholderia species, and it is an excellent surrogate as it rarely causes disease in humans. Understanding the complex molecular mechanisms that cha […]
- GSE266357 A comparative analysis across species of maternal mRNA regulation in embryos July 13, 2025Contributors : Michal Rabani ; Mazal TawilSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe post-transcriptional regulation of mRNAs greatly impacts gene expression dynamics, but the underlying regulatory rules and how they change between organisms remain elusive. During early metazoan development, thousands of pre-loa […]
- GSE282794 Effect of PRMT5i (MRTX1719) on glioblastoma cell line (A172) July 13, 2025Contributors : Kathleen Mulvaney ; William R Sellers ; Devishi Kesar ; Guangyan Li ; Eliana DestefanisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCDKN2A/MTAP co-deletion occurs frequently in non-small cell lung cancer and other solid tumors including glioblastoma and pancreatic ductal adenocarcinoma. Lung cancer rem […]
- GSE280815 Synergistic enhancement of SvLAC-1 gene expression by strong promoter and surfactant: A novel strategy to improve laccase production in Inocutis levis July 13, 2025Contributors : Yanjun Ma ; Pengcheng Di ; Zilu Song ; Lanlan YuSeries Type : Expression profiling by high throughput sequencingOrganism : Inocutis levisLaccase content was determined under the influence of different concentrations of Triton X-100, and the key enzyme genes were cloned, and finally the expression of laccase was improve by strong promoter subst […]
- GSE282795 Effect of PRMT5i (MRTX1719), ERKi (Adagrasib), RAFi (Belvarafenib) and their combination on non-small cell lung cancer cell line (LU99) July 13, 2025Contributors : Kathleen Mulvaney ; William R Sellers ; Devishi Kesar ; Guangyan Li ; Eliana DestefanisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCDKN2A/MTAP co-deletion occurs frequently in non-small cell lung cancer and other solid tumors including glioblastoma and pancreatic ductal adenocarcinoma. Lung cancer rem […]
- GSE296643 Differential expression of circRNAs in virus infection July 13, 2025Contributors : Jun Zhang ; Ao Zhang ; Ranran YaoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensThere is increasing evidence showing that aberrant expressions of circRNAs are implicated in various physiological or pathological processes. Yet, their roles in antiviral innate immunity remain unknown. To reveal the implications of circRNAs […]
- GSE301770 Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells July 13, 2025Contributors : Benura Azeroglu ; Wei Wu ; Raphael Pavani ; Ranjodh Sandhu ; Tadahiko Matsumoto ; Andre Nussenzweig ; Eros Lazzerini DenchiSeries Type : OtherOrganism : Canis lupus familiaris ; Homo sapiens ; Mus musculusA significant portion of human cancers utilize a recombination-based pathway, Alternative Lengthening of Telomeres (ALT), to maintain telome […]
- GSE267990 Mutant GFAP alters lineage commitment of neural organoids [AxDorganoids_bulk_experiment2] July 13, 2025Contributors : Werner Dykstra ; Zuzana Matusova ; Rachel A Battaglia ; Pavel Abaffy ; Nuria Goya-Iglesias ; Dolores Perez-Sala ; Henrik Ahlenius ; Mikael Kubista ; R J Pasterkamp ; Li Li ; Jianfei Chao ; Yanhong Shi ; Lukas Valihrach ; Milos Pekny ; Elly M HolSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlial fibrill […]
- GSE276836 ATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity July 13, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.