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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294205 A longitudinal single cell analysis of GLP-2 treatment in the patients with short bowel syndrome July 8, 2025Contributors : Yumi Kudo ; Kentaro Miyamoto ; Akihiko Chida ; Anna Tojo ; Ikuko Koya ; Yoshinari Ando ; Shohei Suzuki ; Masayasu Sato ; Aya Kondo ; Tomoko Kumagai ; Harunori Deguchi ; Yoshiki Sugiyama ; Koji Shirosaki ; Satoko Yamagishi ; Yutaro Maeda ; Hiroki Kanamori ; Motohiro Kano ; Mototoshi Kato ; Hanako Tsujikawa ; Yusuke Yoshimatsu ; Kaoru Takabayash […]
- GSE298921 Salivary gland transcriptomic analysis in the IL-14α transgenic mouse model of Sjögren’s disease using Visium V1 3' spatial gene expression assay July 8, 2025Contributors : Lucas T Woods ; Kimberly J Jasmer ; Kevin Munoz Forti ; Alex Kearns ; Gary A WeismanSeries Type : OtherOrganism : Mus musculusSjögren’s disease (SjD) is a systemic autoimmune disorder primarily affecting the exocrine glands and characterized by dry mouth and dry eye, the presence of anti-SSA and/or anti-SSB autoantibodies in blood serum, and c […]
- GSE297734 Epigenetic silencing of JAM3 promoted progression in serous ovarian carcinoma through PI3K/AKT pathway July 8, 2025Contributors : Haiyan Wang ; Chunlei Wen ; Jiling Xie ; Jiandong Wang ; Wenxiu YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensJunctional adhesion molecule 3 (JAM3) is frequently epigenetically silenced in cancers, but its functional role and regulatory mechanisms in serous ovarian carcinoma (SOC) remained poorly de […]
- GSE244179 Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing July 8, 2025Contributors : Pablo Baeza-Centurion ; Belén Miñana ; Andre J Faure ; Mike Thompson ; Sophie Bonnal ; Ben Lehner ; Juan ValcárcelSeries Type : OtherOrganism : Homo sapiensAltered splicing is a frequent mechanism by which genetic variants cause disease. However, the regulatory architecture of human exons remains poorly understood, making the therapeutic modul […]
- GSE212922 Differential gene expression analysis at different stages of neuronal development in mutant and wild type ATRX cells July 8, 2025Contributors : Marie-Therese El-Daher ; Graeme R Grimes ; Yanick J CrowSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInvestigating transcription deregulation and interferon signaling activation in iPSC-derived neurons deficient for ATRX.
- GSE283591 Comprehensive multi-omics analysis uncovers potential risks of aged sperm on offspring development after short-term storage [RNA-Seq] July 8, 2025Contributors : Yu Cheng ; Sayyed Mohammad Hadi Alavi ; Songpei Zhang ; Rigolin Nayak ; Swapnil Gorakh Waghmare ; Deepali Rahi Roy ; Nururshopa Eskander Shazada ; Zhijun Ma ; Otomar Linhart ; Zuzana LinhartováSeries Type : Expression profiling by high throughput sequencingOrganism : Cyprinus carpioIn vitro short-term sperm storage is a common method used for […]
- GSE273038 Spatiotemporal Mouse Brain Profiling Reveals Anti-Aging Mechanisms of Caloric Restriction July 8, 2025Contributors : Alexander Epstein ; Zehao Zhang ; Chloe Schaefer ; Abdulraouf Abdulraouf ; Weirong Jiang ; Wei Zhou ; Junyue CaoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusAging induces functional declines in the mammalian brain, increasing its vulnerability to cognitive impairments and neurodegenerative diso […]
- GSE301942 Targeting VRK2 Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma by Reducing Direct Phosphorylation and Stability of MYC，CUT-TAG sequencing for MYC in hepatocellular carcinoma cells [CUT&Tag] July 8, 2025Contributors : Chen Su ; Zhibin Liao ; Jie Mo ; Furong Liu ; Zhanguo Zhang ; Peng Zhu ; Bixiang ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensVRK2–MYC axis, a transcription-dependent regulatory axis, could be a prognostic indicator and potential therapeutic target in liver cancer.
- GSE301928 Structural and molecular insights into specialized translation mediated by the ribosome mRNA-binding channel [Ribo-Seq] July 8, 2025Contributors : Davide Fraticelli ; Disha-Gajanan Hiregange ; Benjamin Weiss ; Ariel Ogran ; Tal Havkin-Solomon ; Irene Martinez-Roman ; Anat Bashan ; Ada Yonath ; Rivka DiksteinSeries Type : OtherOrganism : Homo sapiensThe ribosome mRNA channel is central for translation, but its involvement in specific regulatory mechanisms remains unexplored. Employing Cry […]
- GSE301994 Sing cell RNA sequence analysis of control and P4HA1 KO mouse mammary gland July 8, 2025Contributors : Ren Xu ; Jinpeng LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study, we investigated the role of P4HA1 in mouse mammary glands by analyzing single cell gene expression profiles across two mouse groups: control (5Ht) and P4HA1-knockout (6Ho) mice.
- GSE301971 Modelling HNSCC in mice with hyperactivated NRF2 pathway July 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Alterations in the KEAP1/NFE2L2 (NRF2)/CUL3 pathway occur in ~20% of human head and neck squamous cell carcinomas (HNSCC) and are associated with resistance to standard-of-care therapy. However, this pathway's role in radiotherapy resistance in HNSCC has not […]
- GSE302001 RNA Sequencing-Based Profiling of Differentially Expressed MicroRNAs in Endothelial Cells from Offspring of Hypertensive Pregnancies July 8, 2025Contributors : Nurul Iffah Mohd Isa ; Adila A Hamid ; Aslah Nabilah Abdull Sukor ; Saiful Effendi Syafruddin ; Mohd Faizal Ahmad ; Shahidee Zainal Abidin ; Azizah Ugusman ; Mohd Helmy MokhtarSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensOffspring of mothers with hypertensive disorders of pregnancy (HDP) are at inc […]
- GSE302065 A Human-Mouse Atlas of Intrarenal Myeloid Cells in Lupus Nephritis Identifies Conserved Disease-Associated Macrophages July 8, 2025Contributors : Paul J Hoover ; Chirag Raparia ; David J Lieb ; Yochay Tzur ; Joyce Kang ; Arnon Arazi ; Rollin Leavitt ; Sujal I Shah ; Daimon Simmons ; Stephen Li ; Michael Peters ; Thomas Eisenhaure ; Timothy J Few-Cooper ; Saisram S Gurajala ; Abraham Sonny ; Jeffrey Hodgin ; Joel M Guthridge ; Andrea Fava ; Robert Clancy ; Chaim Putterman ; Peter Izmirly […]
- GSE302076 The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies [ChIP-Seq] July 8, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRibosome biogenesis (RiBi) is a key determinant of cell growth and proliferation and is highly elevated in cancer due to the activation by oncogenes such as MYC. First-generation RiBi inhibitor CX-5461, while demonstrating clinical potential for cancer treatm […]
- GSE292890 Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells [HPAF-2] July 8, 2025Contributors : Marcella Bonanomi ; Sara Mallia ; Mariafrancesca Scalise ; Tecla Aramini ; Federica Baldassari ; Elisa Brivio ; Federica Conte ; Alessia Lo Dico ; Matteo Bonas ; Danilo Porro ; Cesare Indiveri ; Christian M Metallo ; Daniela GaglioSeries Type : Expression profiling by arrayOrganism : Homo sapiensPancreatic cancer is one of the most lethal mali […]