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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE256126 Evalation of Vitamin D and Doxercalciferol Effect on Uterine Fibroid Growth July 2, 2025Contributors : Ana Corachán ; Maria V Bariani ; Mohamed Ali ; Qiwei Yang ; Hortensia Ferrero ; Ayman Al-HendySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUterine fibroids (UF) are the most common pelvic tumor in women of reproductive age. Despite its high prevalence, there is an unmet need in the field for a non-horm […]
- GSE247122 Effect of acute and chronic ATF6 activation on gene expression in the colonic epithelium, in specific pathogen-free and germ-free mice. July 2, 2025Contributors : Olivia I Coleman ; Sandra Bierwirth ; Philipp Rosenstiel ; Tim Kacprowski ; Christina SchmidtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related tr […]
- GSE271435 Gene expression profile at single cell level of pulmonary endarterectomy surgical specimens from chronic thromboembolic pulmonary hypertension (CTEPH) July 2, 2025Contributors : Hon-Sum J Man ; Yidan Zhao ; Marc de PerrotSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndothelial cells are implicated in delayed thrombus resolution. We use single cell RNA sequencing of CTEPH surgical specimens to assess endothelial cell phenotypes that contribute to delayed thrombus resolution. […]
- GSE260481 Metastatic immunoediting in breast cancer cells July 2, 2025Contributor : Rozalen CatalinaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring the metastatic process, most of the disseminated tumor cells fail to adapt to new tissue conditions upon arrival and die, resulting in a selection of the fittest cells. Among these hurdles, the immune system’s anti-tumor activity is one […]
- GSE273352 The effect of circRNA PTPN4 on epilepsy-induced blood brain barrier disruption and the mechanism involved July 2, 2025Contributor : Jiurong YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAn increasing body of evidence suggests that blood brain barrier (BBB) integrity is disrupted in the epileptic brain. However, the mechanisms of epilepsy-induced BBB disruption are still unclear. Recently, circular RNA has attracted increasing att […]
- GSE273095 Decades-long elevation of interferon-alpha can initiate and drive Sjogren syndrome I July 2, 2025Contributors : Deborah Forbes ; Ivana Jorgacevic ; Kilian Kleemann ; Jessica Tarn ; David Hunt ; Rayk Behrendt ; Fai NgSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSjogren syndrome (SS) is a chronic inflammatory disease with no effective targeted treatments. There is a pressing need to identify targetable pathways wh […]
- GSE300844 Deciphering the functional impact of Alzheimer’s Disease-associated variants in resting and proinflammatory immune cells July 2, 2025Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE301136 Roles of 3'UTR and IDR in regulating activity and chromatin localization of JMJD3 [ChIP-seq] July 2, 2025Contributors : Yang Luo ; Pierre-Jacques Hamard ; Richard Koche ; Christine MayrSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensJMJD3 cellular activity can be regulated by altered chromatin localization to genomic targets or by protein conformation changes that alter its catalytic activity. We found that t […]
- GSE300930 Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice alters adipokine secretion and improves cerebrovascular health July 2, 2025Contributors : Florine Seidel ; Martine C Morrison ; Ilse Arnoldussen ; Vivienne Verweij ; Joline Attema ; Christa de Ruiter ; Wim van Duyvenvoorde ; Jessica Snabel ; Bram Geenen ; Ayla Franco ; Maximilian Wiesmann ; Robert Kleemann ; Amanda J KiliaanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusVisceral white adipose […]
- GSE300865 Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants July 2, 2025Contributors : Ross M Giglio ; Anne E van Vlimmeren ; José L McFaline-Figueroa ; Neel H ShahSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe protein tyrosine phosphatase SHP2, encoded by PTPN11, is an important regulator of Ras/MAPK signaling and a signaling hub downstream of receptor tyrosine kinases and other trans […]
- GSE300996 Cancer-Associated Fibroblast-derived exosomal LINC02420 drives glycolytic reprogramming via AEG-1/HIF-1α to promote Laryngeal Cancer progression July 2, 2025Contributor : Yun LiSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensLaryngeal squamous cell carcinoma (LSCC) has an insidious onset and strong heterogeneity. The lack of effective biomarkers makes early diagnosis difficult. Liquid biopsy technology provides a new direction to break through this bottleneck. The co-culture model of CAFs a […]
- GSE301059 transglutaminase 2 (TGM2) and Its Novel Targeted Activator in Diabetic Bone Regeneration: From Mechanism to Application July 2, 2025Contributors : Dian Gan ; Xuan Li ; Faming ChenSeries Type : Non-coding RNA profiling by arrayOrganism : Rattus norvegicusTo screen and identify key molecule regulating T2DM (Type 2 diabetes mellitus)-impaired bone regeneration, cellular osteogenic potential and mitochondrial function, and to elucidate the regulatory mechanisms of this molecule. Microarray a […]
- GSE301135 3'UTR-dependent activity of transcription factors and chromatin regulators [RNA-seq] July 2, 2025Contributors : Yang Luo ; Mervin Fansler ; Christine MayrSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOver 2700 human mRNAs have highly conserved 3'UTRs, but their biological functions are unknown. These mRNAs enrich for transcriptional regulators. Therefore, we performed RNA-seq to determine the roles of 3
- GSE239709 p63 and its co-binding factor Znf148 cooperate to control squamous cell carcinoma proliferation July 2, 2025Contributors : Rosalba Pecorari ; Mara Mancini ; Giacomo Corleone ; Artem Smirnov ; Flavia Novelli ; Anna M Lena ; Michele Caraglia ; Alessandro Mauriello ; Maurizio Fanciulli ; Gerry Melino ; Eleonora CandiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHead and neck squamous cell carcinoma (HNSCC) are co […]
- GSE300841 Deciphering the functional impact of Alzheimer’s Disease-associated variants in resting and proinflammatory immune cells [crispr] July 2, 2025Contributors : Marielle Bond ; Yoseli Quiroga-Barber ; Brianne Rogers ; Susan D'Costa ; Yija Wu ; Jessica Bell ; Jessica McAfee ; Quinn Johnson ; Ashlyn Anderson ; Alejandro Gomez ; Won Ma ; Nicole Kramer ; Sool Lee ; Sylvie Parkus ; Mary Patrucco ; Jeremy Burgess ; Adriana Beltran ; Nicholas Cochran ; Douglas Phanstiel ; Hyejung WonSeries Type : Expres […]