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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE272148 CUT&Tag in Bacteria Reveals Unconventional G-Quadruplex Landscape in Mycobacterium tuberculosis in Response to Oxidative Stress June 20, 2025Contributors : Ilaria Maurizio ; Emanuela Ruggiero ; Irene Zanin ; Marta Conflitti ; Giulia Nicoletto ; Roberta Provvedi ; Sara N RichterSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains a global health threat due to […]
- GSE273753 Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia b June 20, 2025Contributors : Hannah D Mason ; Yvonne L Latour ; Christopher T Boughter ; Kory R Johnson ; Dragan Maric ; Cayce E Dorrier ; Vivian A Guedes ; Chen Lai ; Patrick C Duncker ; Alexis M Johnson ; Monica Manglani ; Jessica M Gill ; Daniel P Perl ; Martin Meier-Schellersheim ; Dorian B McGavernSeries Type : Expression profiling by high throughput sequencingOrgani […]
- GSE272150 CUT&Tag in Bacteria Reveals Unconventional G-Quadruplex Landscape in Mycobacterium tuberculosis in Response to Oxidative Stress June 20, 2025Contributors : Ilaria Maurizio ; Emanuela Ruggiero ; Irene Zanin ; Marta Conflitti ; Giulia Nicoletto ; Roberta Provvedi ; Sara N RichterSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains a global health threat due to increasing dr […]
- GSE206726 Epigenetic reprogramming of the mesenchymal state by SUV39H1/H2 [ChIP-Seq] June 20, 2025Contributors : Junichi Hanai ; Noriko Ide ; Alex O Gulka ; Jingyu Zhang ; Gracia Bonilla ; Ruslan Sadreyev ; Toshi Shioda ; Mo MotamediSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEmergence of chemotherapy resistance is a major clinical challenge resulting in large number of deaths yearly. One mechanism […]
- GSE300237 Inhibition of S1PR4 and supplementation of APOM in Alport Podocytes June 20, 2025Contributors : Alessia Fornoni ; Sandra Merscher ; Anthony GriswoldSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Renal lipid dysmetabolism contributes to glomerular disease progression, including Alport Syndrome. We recently identified alterations in the apolipoprotein M/sphingosine-1-phosphate/sphingosine […]
- GSE266983 m6A-modified RNAs in human amniotic epithelial stem cells derived-insulin-producing cells: Wild type vs. overexpressed METTL3 plasmid transfected June 20, 2025Contributors : Yunfei Luo ; Jianping LiuSeries Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Homo sapiensm6A-modified RNAs expression profiles of human amniotic epithelial stem cells differentiation into insulin-producing cells and comparing Wild type with overexpressed METTL3 plasmid transfected.Goal was to determine the […]
- GSE235297 Next Generation Sequencing Facilitates Quantitative Analysis of WT and Glut10ko CD8+ T cells lymphoma June 20, 2025Contributors : Ke Li ; Ying Liu ; Feng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to analysis the differiational genes and pathways in WT and Glut10 ko CD8+ T lymphoma cells by u […]
- GSE298072 RNA-seq samples of Escherichia coli MG1655 for regulatory network analysis June 20, 2025Contributors : Ye Gao ; Richard Szubin ; Ying Hefner ; Bernhard O PalssonSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli str. K-12 substr. MG1655Transcriptomic data is accumulating rapidly. We assembled a top-down expression and regulation knowledge base for Escherichia coli. High-quality RNA-seq compendium consist […]
- GSE297557 Age-associated Tissue Organization Shifts Retinal Pigmented Epithelium Actomyosin Plasticity in Phagocytosis June 20, 2025Contributors : Teodora Piskova ; Aleksandra N Kozyrina ; Giedrė Astrauskaitė ; Mohamed Elsafi Mabrouk ; Sebastian Schepl ; Stacy Lok Sze Yam ; Ragul Ravithas ; Wolfgang Wagner ; Massimo Vassalli ; Jacopo Di RussoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMechanical homeostasis in healthy tissues relies on a dynamic […]
- GSE299729 Overexpression of NPY leads to a progressive, cutaneous inflammatory fibrotic response in mouse skin. June 20, 2025Contributors : Dawson D Alex ; Harris L MelissaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuropeptide Y (NPY) is a pleiotropic peptide produced in the central nervous system and peripheral organs and is upregulated in some human skin conditions like atopic dermatitis. We reported previously that a knock-in mouse w […]
- GSE299290 Targeted pseudouridylation identifies a novel Ψ-Ψ codon-anticodon pairing in nonsense suppression and translational recoding June 20, 2025Contributors : Yi-Tao Yu ; Yi PanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Saccharomyces cerevisiaePseudouridine (Ψ) is known for decades, but its flexibility in base-pairing remains unclear. This study engineers artificial box H/ACA guide RNAs to direct pseudouridylation at the uridine of a premature termination codo […]
- GSE299784 GATA Transcription Factors Coordinate Developmental Progression in the Arabidopsis Root June 20, 2025Contributors : Tom Denyer ; Pavel Solansky ; Francesco de Martino ; Efthymia Symeonidi ; Arvid Herrmann ; Valentin Brösamle ; Marja TimmermansSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaFor proper organ development, cell proliferation and cellular differentiation must balance in a tightly regul […]
- GSE299800 m5C-MeRIP-seq of HHL5 cells June 20, 2025Series Type : OtherOrganism : Homo sapiensWe discovered the YBX1 in the lipid-induced particles assembled by DDX49, YBX1 is an m5C reader and constitutively associates with Timp2 mRNA in hepatocytes, we examined whether their association was dependent on the m5C modification of Timp2 mRNA, then we performed m5C-MeRIP-seq.
- GSE299805 RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice June 20, 2025Contributor : Bochuan LiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAtherosclerosis preferentially occurs in atheroprone vasculature where human umbilical vein endothelial cells (HUVECs) are exposed to disturbed flow. Disturbed flow is associated with vascular inflammation and focal distribution. Recent stud […]
- GSE271050 Transcriptome profiling of developing testes in the horse [RNA-seq] June 20, 2025Contributors : Paula Navarrete-López ; Cristina García-Merino ; Eva Pericuesta ; Alfonso Gutiérrez-AdánSeries Type : Expression profiling by high throughput sequencingOrganism : Equus caballusThe mammalian testis is a highly heterogeneous tissue with a vast array of functional and regulatory RNA molecules that participate in the timely control of the spermat […]