Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE273434 Multiway chromatin conformation analyses at the human immunoglobulin heavy chain locus reveal regulatory principles underlying somatic hypermutation June 16, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE271908 HDAC1 acts as tumor suppressor in ALK-positive anaplastic large-cell lymphoma: Implications for HDAC inhibitor therapy [ATAC-Seq] June 16, 2025Contributors : Masa Zrimsek ; Anna Malzer ; Carlos U Malla ; Raheleh Sheibani-Tezerji ; Gerda EggerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHistone deacetylases (HDACs) are frequently deregulated in cancer, and several HDAC inhibitors (HDACi) have gained approval for treating peripheral T-cell lymph […]
- GSE279470 The ferret bleomycin-induced model of lung fibrosis shares features of human idiopathic pulmonary fibrosis June 16, 2025Contributors : Engelhardt John ; Liu Xiaoming ; Shuang Wu ; Miyazaki Hikaru ; Shambhu Smitha ; Driver Ian ; Sontake VishwarajSeries Type : Expression profiling by high throughput sequencingOrganism : Mustela putorius furoIn the present study, we report a bleomycin-induced ferret PF model characterized by an irreversible decrease in pulmonary compliance and i […]
- GSE276668 Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development [RNAseq_TL] June 16, 2025Contributor : Yuwei PanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDeveloping gut in mice undergoes rapid elongation during late embryogenesis, yet significantly slows down after birth. Precise regulatory mechanism of this dynamic morphogenetic process remains unknown. Utilizing scRNA-seq analysis, we show that YAP […]
- GSE191190 Droplet-based RNA sequencing and chromatin accessibility of muscles from young and aged mice June 16, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE281589 Multicomponent Parenteral Lipid Emulsions Do Not Protect Against Liver Injury in Neonatal Pigs with Obstructive Cholestasis June 16, 2025Contributor : Gregory GuthrieSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaBiliary atresia (BA) is a pediatric liver disease that often necessitates parenteral nutrition (PN) to support growth due to impaired liver function. While soy oil lipid emulsions (SLE) are commonly used in PN, they may contribute to cholestatic […]
- GSE299663 Effects of alcohol on the transcriptome, methylome, and metabolome of in vitro gastrulating human embryonic cells June 16, 2025Contributors : Essi Wallén ; Karita Rämö ; Jussi Vehviläinen ; Joonas Sokka ; Marko Lehtonen ; Timo Otonkoski ; Ras Trokovic ; Pauliina Auvinen ; Olli Kärkkäinen ; Nina Kaminen-AholaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrenatal alcohol exposure (PAE) affects embryonic development, causing a variable fetal alc […]
- GSE251807 Investigation of gene expression changes in normal human dermal fibroblasts after exposure to bone marrow mesenchymal stromal cell secretome June 16, 2025Contributors : Tamiris Borges da Silva ; Cathy H YeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMesenchymal stromal cells (MSCs) are been widely investigated in clinical trials for several clinical conditions. It is known that these cells do not promote their effects by engrafment and differentiation, as they die sho […]
- GSE299770 Single-cell and in situ spatial analyses reveal the diversity of newly born hematopoietic stem cells and of their niches June 16, 2025Contributors : Lea Torcq ; Catherine Vivier ; Sandrine Schmutz ; Yann Loe-Mie ; Anne A SchmidtSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioHematopoietic stem cells (HSCs) and more committed progenitors (collectively referred to as HSPCs) emerge from vessels during development, via Endothelial-to-Hematopoietic Transiti […]
- GSE299679 Effect of depletion of KLF9 on gene expression of small cell lung cancer cells in vitro June 16, 2025Contributor : Xiaodong MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of KLF9 in the regulation of small cell lung cancer, we established SCLC cell lines (NCI-H146, NCI-H1688) and knocked down KLF9 with shRNA.
- GSE299851 Transcriptional changes in response to TGFB in human pancreatic stellate cells with inhibition of PIN1 June 16, 2025Contributors : Ellen M Langer ; Rosalie C SearsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic stellate cells can be activated to a myofibroblast phenotype in response to TGFB treatment. The goal of this study was to determine how inhibition of PIN1 affects stellate cell state at baseline and in response to T […]
- GSE299852 Transcriptional changes in response to TGFB in human pancreatic stellate cells with knockdown of PIN1 June 16, 2025Contributors : Ellen M Langer ; Rosalie C SearsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic stellate cells can be activated to a myofibroblast phenotype in response to TGFB treatment. The goal of this study was to determine how loss of PIN1 affects stellate cell state at baseline and in response to TGFB tr […]
- GSE299853 Regulating white blood cell activity through the novel Universal Receptive System June 16, 2025Contributors : Victor Tetz ; Kristina Kardava ; Maria Vecherkovskaya ; Alireza Khodadadi-Jamayran ; Aristotelis Tsirigos ; George TetzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegulation of the leucocyte activity is critically important for a properly functioning immune response and the development of novel cell-b […]
- GSE271218 C1q reprograms innate immune memory [RNA-seq] June 16, 2025Contributors : Inge Jonkman ; Maaike M Jacobs ; Yutaka Negishi ; Julia I van Heck ; Vasiliki Matzaraki ; Joost H Martens ; Marijke Baltissen ; Michiel Vermeulen ; Zahi A Fayad ; Abraham J Teunissen ; Willem J Mulder ; Luuk B Hilbrands ; Leo A Joosten ; Mihai G Netea ; Musa M Mhlanga ; Nils Rother ; Raphaël DuivenvoordenSeries Type : Expression profiling by h […]
- GSE299629 ATAC-seq analysis of wildtype and ETV2-overexpressing embryoid body-derived progenitor cells June 16, 2025Contributors : Kidus Hailemariam ; Satyabrata Das ; Xiao MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWild-type (WT) and Etv2-overexpressing (OE) mouse embryonic stem cells (mESC) were cultured and differentated to embryoid bodies (EBs) in mesodermal conditions. Induction of Etv2 in OE EBs was achieve […]