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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE269382 Fetal liver macrophage development and function require Xpr1 June 9, 2025Contributors : Sebastian A Stifter ; Melanie GreterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusErythroblastic island macrophages (EBI-Macs) support the development of red blood cells by recycling iron, producing growth factors,and clearing nuclei expelled from erythroblasts. In the developing embryo, the liver is th […]
- GSE268312 Spatial transcriptomics analysis of a panel of PDX models of GBM June 9, 2025Contributors : Melanie Clements ; Wenhao Tang ; Samuel Marguerat ; Simona ParrinelloSeries Type : OtherOrganism : Homo sapiens ; Homo sapiens/Mus musculus xenograft ; Mus musculusVisium spatial transcriptomics was carried out on ten glioblastoma PDX models and one tumour free age-matched control brain.
- GSE270426 Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease under natural conditions [RNA-Seq] June 9, 2025Contributors : Hanzhi Yu ; Ge Dong ; Zhigang CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic granulomatous disease (CGD) is a rare and hereditary immunodeficiency disorder attributed to a malfunction in the NADPH oxidase 2 (NOX2) of phagocytes. Owing to the deficiency of NOX2-derived reactive oxygen species, […]
- GSE269875 Spatial transcriptomics unveils novel potential disease mechanisms associated with the microenvironment in Multiple Myeloma June 9, 2025Contributors : Laura Sudupe ; Emma Muiños-Lopez ; Ana R Lopez-Perez ; Amaia Vilas-Zornoza ; Sarai Sarvide ; Purificacion Ripalda-Cemborain ; Paula Aguirre-Ruiz ; Patxi San Martin-Uriz ; Marta Larrayoz ; Laura Alvarez-Gigl ; Marta Abengozar ; Itziar Cenzano ; Miguel Cócera ; Javier Ruiz ; Ignacio S González ; Azari Bantan ; Aleksandra Kurowska ; Jin Ye ; Vin […]
- GSE271288 The transcription factor IRF4 regulates the differentiation and function of intestinal ILC3s. June 9, 2025Contributors : Xianzhi Gao ; Lie WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the role of IRF4 in the regulation of ILC3 development and function, we used the IRF4flox/floxRorccre mice and C57BL/6 mice(6-8 weeks-old ) to carry out single-cell RNA sequencing (BD Rhapsody) on gut ILC3s.
- GSE270888 Expression data from uterine tissue of Egr1 knockout mice. June 9, 2025Contributors : Gaehoon Jo ; Haengseok SongSeries Type : Expression profiling by arrayOrganism : Mus musculusMicroarrays have been widely used to study estrogen responses, as estrogen-induced transcriptome changes significantly impact the uterus. This study investigates the gene expression profiling of Egr1 knockout (KO) mice treated with estrogen. Our goal i […]
- GSE296035 Transcriptional landscape of the cell cycle in a model thermoacidophilic archaeon reveals similarities to eukaryotes June 9, 2025Contributors : Miguel V Gomez-Raya-Vilanova ; Jérôme Teulière ; Sofia Medvedeva ; Yuping Dai ; Eduardo Corel ; Philippe Lopez ; François-Joseph Lapointe ; Debashish Bhattacharya ; Louis-Patrick Haraoui ; Elodie Turc ; Marc Monot ; Virginija Cvirkaite-Krupovic ; Eric Bapteste ; Mart KrupovicSeries Type : Expression profiling by high throughput sequencingOrgan […]
- GSE299038 Downregulation of Engulfment and cell motility 1 (Elmo1) induces quiescence and resistance to poly(I:C)-induced apoptosis in endothelial cells June 9, 2025Contributors : Yukako Kayashima ; Anshulika Ashvinikumar Deshmukh ; Nobuyo MaedaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEngulfment and Cell Motility 1 (ELMO1) facilitates activation of Ras-related C3 botulinum toxin substrate 1 (RAC1) through interaction with Dedicator of Cytokinesis (DOCK), a family of guanine […]
- GSE298818 DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation June 9, 2025Contributors : Colin Trepicchio ; Charlotte KuperwasserSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding epithelial stem cell differentiation and morphogenesis during breast tissue development is essential, as disruption in these processes underlie breast cancer formation. Recent work has shown that epitheli […]
- GSE298747 Key molecular pathways associated with therapy resistance in AML June 9, 2025Contributors : Fadeev S Roman ; Kobyakova I Margarita ; Lomovskaya V Yana ; Krasnov S Kirill ; Meshcheriakova I ElenaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the rapid proliferation of immature myeloid cells in the bone marrow, […]
- GSE298935 Mettl3 maintains genome stability of erythroid cells via Mthfd1-mediated nucleotide biosynthesis June 9, 2025Contributors : Linlin Zhang ; Huizhi Zhao ; Xiaoli QuSeries Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Mus musculusN6-methyladenosine (m6A) is a prevalent modification of mammalian mRNA. Increasing evidence has documented diverse roles of m6A in normal cell physiology and diseases […]
- GSE298982 Identification of glutamate-regulated genes in Arabidopsis seedlings June 9, 2025Contributors : Jia-Ming Chang ; Yi-Jie Hung ; Ming-Hsiun HsiehSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTo understand the global effect of Glu on gene expression, we performed RNA-seq analysis to compare the gene expression profiles between 12-day-old Arabidopsis seedlings grown on 5 mM NH4NO3 and 5 mM Glu […]
- GSE298998 Visfatin facilitates esophageal cancer migration by suppressing miR-3613-5p expression and promoting VEZF1/VCAN production June 9, 2025Contributors : Chih-Hsin Tang ; Shubham Suresh GhuleSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensEsophageal cancer, one of the most prevalent cancers worldwide, frequently exhibits distant metastases. The adipokine visfatin has been implicated in cancer progression and metastasis. However, the mechanisms by which […]
- GSE267973 Analyzing small RNA sequences from canine stem cell-derived extracellular vesicles primed with TNF-α and IFN-γ June 9, 2025Contributor : Ju-Hyun ANSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Canis lupus familiarisAcute lung injury is an acute inflammation disorder that disrupts the lung endothelial and epithelial barriers. In this study, we investigated the extracellular vesicles (EVs) obtained via priming inflammatory cytokines such as tumor n […]
- GSE284647 The genotype-integrated gene expression profile at the single-cell level of bone marrow CD34-positive hematopoietic stem and progenitor cells (HSPCs) from a patient with myelodysplastic neoplasms (MDS) harboring germline and somatic DDX41 variants. June 9, 2025Contributors : Hirotaka Matsui ; Shigeyuki ShichinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDDX41 is recognized as a major gene responsible for myeloid neoplasms associated with germline predisposition. Individuals typically inherit a germline pathogenic variant in one allele and later acquire a somatic variant—m […]