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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE267275 The m6A-mediated TGF-β-SMAD signaling axis regulates ccRCC progression [LACE-seq] June 5, 2025Contributors : Bo Peng ; Shuwen Cheng ; Liqiang Duan ; Shan GaoSeries Type : OtherOrganism : Homo sapiensTGF-β-SMAD signaling pathway plays an important role in progression of various tumors. However, posttranscriptional regulation such as N6-methyladenosine (m6A) of TGF-β-SMAD signaling axis remains incompletely understood. Here, we reveal that Insulin like […]
- GSE276843 Distinct proliferative and neuronal programmes of ASCL1 chromatin binding and gene activation are cell cycle stage dependent [RNA] June 5, 2025Contributor : William BeckmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensASCL1 is a potent proneural factor with opposing functions during development, promoting both neuronal progenitor pool expansion and terminal differentiation. How one factor can execute, and switch between, such contradictory functions remain t […]
- GSE271344 Histone H3.14 variant is an early player in the abiotic stress response of Arabidopsis [RNA-seq] June 5, 2025Contributors : Rocio Nunez-Vazquez ; Sofía Madeira ; Laura Rodriguez-Casillas ; Diego Gomez-Martinez ; Bénédicte Desvoyes ; Crisanto GutierrezSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaHere we have focused on H3.14, a H3 variant which is expressed at very low levels under normal growth conditions. We found […]
- GSE282575 Regulation of epigenetics and chromosome structure by human ORC2 [ORC1 ChECseq] June 5, 2025Contributors : Zhangli Su ; Mengxue Tian ; Etsuko Shibata ; Yoshiyuki Shibata ; Tianyi Yang ; Zhenjia Wang ; Fulai Jin ; Chongzhi Zang ; Anindya DuttaSeries Type : OtherOrganism : Homo sapiensThe six subunit Origin Recognition Complex (ORC) is a DNA replication initiator that also promotes heterochromatinization in some species. A multi-omics study in a huma […]
- GSE282331 Regulation of epigenetics and chromosome structure by human ORC2 [CUT&RUN] June 5, 2025Contributors : Zhangli Su ; Mengxue Tian ; Etsuko Shibata ; Yoshiyuki Shibata ; Tianyi Yang ; Zhenjia Wang ; Fulai Jin ; Chongzhi Zang ; Anindya DuttaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe six subunit Origin Recognition Complex (ORC) is a DNA replication initiator that also promotes heterochro […]
- GSE133923 Serial Sampling of the Small Airway Epithelium Over 1 Year in the Same Individuals to Identify “Public” Genes Commonly Dysregulated by Smoking [array] June 5, 2025Contributors : Yael Strulovici-Barel ; Jacqueline Salit ; Sushila Senoy ; Sarah L O’Beirne ; Robert J Kaner ; Juergen Schymeinsky ; Karsten Quast ; Sudha Visvanathan ; Jay S Fine ; Matthew J Thomas ; Jason G Mezey ; Ronald G CrystalSeries Type : Expression profiling by arrayOrganism : Homo sapiensBackground: The small airway epithelium (SAE, >6th generati […]
- GSE282921 Regulation of epigenetics and chromosome structure by human ORC2 [ATACseq 2] June 5, 2025Contributors : Zhangli Su ; Mengxue Tian ; Etsuko Shibata ; Yoshiyuki Shibata ; Tianyi Yang ; Zhenjia Wang ; Fulai Jin ; Chongzhi Zang ; Anindya DuttaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe six subunit Origin Recognition Complex (ORC) is a DNA replication initiator that also promotes heterochro […]
- GSE299005 Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses June 5, 2025Contributors : Packer Jonathan ; Bray Chelsea ; Beckman Nicolas ; Wangler Lynde ; Davis Amara ; Goodman Ethan ; Godbout JonathanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuropsychiatric complications including depression and cognitive decline develop in the years after traumatic brain injury (TBI), negatively aff […]
- GSE299004 Multiplexed DNA Affinity purification sequencing (multiDAP-seq) of flowering plants [Oryza sativa] June 5, 2025Contributors : Leo Baumgart ; Sharon Greenblum ; Abraham Morales-Cruz ; Peng Wang ; Yu Zhang ; Ronan O'MalleySeries Type : OtherOrganism : Oryza sativaWe applied multiplexed DNA affinity purification sequencing (multiDAP-seq) to profile the binding landscapes of 360 transcription factors (TFs) across ten flowering-plant genomes. Genomic DNA fragment lib […]
- GSE299020 Multiplexed DNA Affinity purification sequencing (multiDAP-seq) of flowering plants [Sorghum bicolor] June 5, 2025Contributors : Leo Baumgart ; Sharon Greenblum ; Abraham Morales-Cruz ; Peng Wang ; Yu Zhang ; Ronan O'MalleySeries Type : OtherOrganism : Sorghum bicolorWe applied multiplexed DNA affinity purification sequencing (multiDAP-seq) to profile the binding landscapes of 360 transcription factors (TFs) across ten flowering-plant genomes. Genomic DNA fragment […]
- GSE299008 Multiplexed DNA Affinity purification sequencing (multiDAP-seq) of flowering plants [Populus trichocarpa] June 5, 2025Contributors : Leo Baumgart ; Sharon Greenblum ; Abraham Morales-Cruz ; Peng Wang ; Yu Zhang ; Ronan O'MalleySeries Type : OtherOrganism : Populus trichocarpaWe applied multiplexed DNA affinity purification sequencing (multiDAP-seq) to profile the binding landscapes of 360 transcription factors (TFs) across ten flowering-plant genomes. Genomic DNA fragm […]
- GSE299024 Multiplexed DNA Affinity purification sequencing (multiDAP-seq) of flowering plants [Solanum lycopersicum] June 5, 2025Contributors : Leo Baumgart ; Sharon Greenblum ; Abraham Morales-Cruz ; Peng Wang ; Yu Zhang ; Ronan O'MalleySeries Type : OtherOrganism : Solanum lycopersicumWe applied multiplexed DNA affinity purification sequencing (multiDAP-seq) to profile the binding landscapes of 360 transcription factors (TFs) across ten flowering-plant genomes. Genomic DNA frag […]
- GSE299026 Multiplexed DNA Affinity purification sequencing (multiDAP-seq) of flowering plants [Solanum tuberosum] June 5, 2025Contributors : Leo Baumgart ; Sharon Greenblum ; Abraham Morales-Cruz ; Peng Wang ; Yu Zhang ; Ronan O'MalleySeries Type : OtherOrganism : Solanum tuberosumWe applied multiplexed DNA affinity purification sequencing (multiDAP-seq) to profile the binding landscapes of 360 transcription factors (TFs) across ten flowering-plant genomes. Genomic DNA fragmen […]
- GSE299028 Multiplexed DNA Affinity purification sequencing (multiDAP-seq) and single-nuclei RNA-seq of flowering plants June 5, 2025Series Type : OtherOrganism : Arabidopsis lyrata ; Arabidopsis thaliana ; Brachypodium distachyon ; Brassica oleracea ; Camelina sativa ; Capsella rubella ; Fragaria vesca ; Oryza sativa ; Panicum hallii ; Populus trichocarpa ; Solanum lycopersicum ; Solanum tuberosum ; Sorghum bicolor ; Thlaspi arvenseThis SuperSeries is composed of the SubSeries listed bel […]
- GSE234210 Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling June 5, 2025Contributors : Heiko Bugger ; Sayan BakshiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSirtuin 4 (SIRT4) is a mitochondrially-localized stress-responsive NAD+-dependent deacylase predominantly regulating energy metabolism and ROS homeostasis. While SIRT4 has been implicated in pathological cardiac hypertrophy, underl […]