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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE234361 The Effects of MIZ1 Deficiency on Germinal Center B Cells in the Light Zone [RNA-seq] June 7, 2025Contributors : Dinis Calado ; Lingling Zhang ; Amparo Toboso-NavasaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe germinal center (GC) reaction is a critical process for the generation of high-affinity antibodies and the establishment of immunological memory. Within the GC, B cells undergo a series of tightly regul […]
- GSE234360 Identification of Transcription Factor MIZ1 Binding Sites in Human B Cell Lines [ChIP-seq] June 7, 2025Contributors : Dinis Calado ; Arief Gunawan ; Lingling ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensA previous study has successfully identified the binding sites of Transcription Factor MIZ1 in murine B cells. In order to shed light on the potential relevance between mouse and human, this experime […]
- GSE269369 LIN28B-mediated activation of the PI3K/AKT pathway promotes metastasis and unravels a new therapeutic vulnerability in colorectal cancer June 7, 2025Contributors : Alice E Shin ; Anil K RustgiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) remains a leading cause of cancer death, primarily due to metastatic spread. LIN28B, an RNA-binding protein overexpressed in 30% of CRCs, acts as an oncogene and promotes CRC metastasis. However, the mechan […]
- GSE249739 Hemolytic stress leads to expansion of erythropoiesis in the spleen June 7, 2025Contributors : Irina L Dubach ; Florence Vallelian ; Livio Baselgia ; Elena DuerstSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn anemia-stressed mice, compensatory RBC production occurs primarily in the spleen. We have compared erythropoiesis across the three models with a multiplexed single cell-RNA sequencing expe […]
- GSE269444 In vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion [in vitro] June 7, 2025Contributors : Cong Fu ; Ashwin V Kammula ; Sarah Y Kim ; Ravindra Uppaluri ; Robert T MangusoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with a high unmet need for enhancing immunotherapy given current modest responses. H […]
- GSE269389 RNA-seq revealed the protective effect of Huangqi Guizhi Wuwu Decoction against cisplatin induced PC12 cell injury June 7, 2025Contributors : C Jie ; D Yuan ; T YuChen ; D ZhiQiangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusChemotherapy-induced peripheral neuropathy (CIPN) not only impacts chemotherapy regimens but also causes intolerable and long-lasting effects on cancer patients. Currently, duloxetine is the only drug used to treat […]
- GSE269446 In vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion June 7, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE269445 In vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion [in vivo] June 7, 2025Contributors : Cong Fu ; Ashwin V Kammula ; Sarah Y Kim ; Ravindra Uppaluri ; Robert T MangusoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with a high unmet need for enhancing immunotherapy given current modest responses. H […]
- GSE276437 The Tumor-Sentinel Lymph Node Immune Migratome Reveals a Key Role for Migratory CCR7+ Dendritic Cells in Response to Immunoradiotherapy [TCR-seq] June 7, 2025Contributors : Robert Saddawi-Konefka ; Shawn M Jensen ; Bernard A Fox ; Richard Bell ; J S Gutkind ; Andrew Sharabi ; Joseph A CalifanoSeries Type : OtherOrganism : Mus musculusSurgical ablation or radiation of tumor-draining lymph nodes can eliminate the primary tumor response to immunotherapy, indicating that local tumor response to immunotherapy is media […]
- GSE276434 The Tumor-Sentinel Lymph Node Immune Migratome Reveals a Key Role for Migratory CCR7+ Dendritic Cells in Response to Immunoradiotherapy [CITE-seq] June 7, 2025Contributors : Robert Saddawi-Konefka ; Shawn M Jensen ; Bernard A Fox ; Richard Bell ; J S Gutkind ; Andrew Sharabi ; Joseph A CalifanoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusSurgical ablation or radiation of tumor-draining lymph nodes can eliminate the primary tumor response to immunotherapy, indicatin […]
- GSE296662 Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid-β-Induced Pathogenesis of Alzheimer's Disease June 7, 2025Contributors : Sijia He ; Xin Li ; Namrata Mittra ; Anindita Bhattacharjee ; Hu Wang ; Shujie Song ; Shangang Zhao ; Feng Liu ; Xianlin HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the impact of microglial cGAS deficiency on gene expression in the 5xFAD mouse cerebrum tissues, using the sin […]
- GSE298520 An engineered hypoxia-response promoter for human umbilical cord-derived mesenchymal stem cell-based therapeutics June 7, 2025Contributors : Song Yang ; Weizhong Zhuang ; Lishi Zhou ; Weiwei Kong ; Wanwan Zou ; Qikun Zhu ; Enze Bian ; Bin Lin ; Jianzheng Cen ; Qiang Gao ; Jimei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyocardial infarction, characterized by insufficient blood supply to the heart, leads to ischemia and hypoxia of myo […]
- GSE298722 TNFα-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy June 7, 2025Contributors : Min-Tae Jeon ; Sinnead Cogill ; Kyu-Sung Kim ; Yongjin Kim ; Hyerin Kim ; Chung-Yeol Lee ; Suji Kim ; Suhyeon Son ; Jeongyeon Kim ; Jaehyeok Lee ; Inyeong Park ; Mookyung Cheon ; Do-Geun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysfunction of the blood brain barrier (BBB) is recognized as a key […]
- GSE299158 Acute Sleep Deprivation Accelerates Brain Endothelial Cell Senescence and Functional Changes of Endothelial Cells in Mice June 7, 2025Contributors : Jinglin Qin ; Changqing Lu ; Yongjing Wang ; Zhenwei Qian ; Chen Zhang ; Xiannian ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSleep, a fundamental physiological process occupying approximately one - third of the human lifespan, is essential for maintaining overall health. Acute sleep deprivation […]
- GSE299230 RNA-seq Analysis Reveals the Anti-inflammatory Role of hnRNPF in Diabetic kidney disease June 7, 2025Contributors : Lan Wang ; Huimeng Li ; Xiaoqin Wang ; Xinyuan GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, a hyperosmotic environment was simulated using 30 mM mannitol. Human renal proximal tubular epithelial (HK-2) cells were transfected to overexpress hnRNP-F, with empty vector-transfected cells […]