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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE268954 Heritable changes in chromatin contacts linked to transgenerational obesity [ChIP-seq] June 3, 2025Contributors : Shioda Toshihiro ; Chang C Richard ; Blumberg BruceSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBurgeoning evidence demonstrates that responses to environmental exposures can be transmitted to subsequent generations through the germline without DNA mutations. This is controversial because […]
- GSE270085 Mitochondria-selective primate cell fusions reveal functional consequences of mitochondrial divergence June 3, 2025Contributors : Daniel A Schmitz ; Leijie Li ; Rashmi Dahiya ; Emily Ballard ; Jun WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Pan troglodytes ; Pongo abeliiInterspecies composite cell lines (or hybrid cells) are powerful tools to study genomic divergence between species. However, to date, the only pluripotent c […]
- GSE269298 Control of Inflammatory Response by Tissue Microenvironment [RNA-seq] June 3, 2025Contributors : Zhongyang Wu ; Diana Leung ; Xu ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation is an essential defense response but operates at the cost of normal functions. Whether and how the negative impact of inflammation is monitored remains largely unknown. Acidification of the tissue microenviron […]
- GSE278054 Dynamic properties of enhancer and promoter during DNA damage in hepatocellular carcinoma [RNA-Seq] June 3, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDNA damage is a critical factor contributing to tumorigenesis, however, the dynamic changes in multi-omics signatures of enhancers and promoters during the DNA damage response (DDR) remain poorly understood. In this study, we discovered that the expression levels, chromati […]
- GSE276657 Dynamics of microcompartment formation at the mitosis-to-G1 transition June 3, 2025Contributors : Viraat Y Goel ; Nicholas G Aboreden ; James M Jusuf ; Haoyue Zhang ; Luisa P Mori ; Leonid A Mirny ; Gerd A Blobel ; Edward J Banigan ; Anders S HansenSeries Type : OtherOrganism : Mus musculusAs cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished, with prior studies showing that essentially all in […]
- GSE227630 Changes in expression of genes +/- CREB3L1 expression June 3, 2025Contributors : Paul Mellor ; Deborah AndersonSeries Type : Expression profiling by arrayOrganism : Homo sapiensAssessing the changes in the expression of genes in the presence of CREB3L1 in human breast cancer cell lines
- GSE298749 Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension June 3, 2025Contributors : Michael A Smith ; Eleana S Guardado ; Jason Boehme ; Sanjeev A Datar ; Emin Maltepe ; Naveen Swami ; Gary W Raff ; Aaron Bodansky ; Prakash Chelladurai ; Joseph Moreno ; Annelise Prince ; Nevan Powers ; Guo N Huang ; Vinicio De Jesus Perez ; Jeffrey R FinemanSeries Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesR […]
- GSE298233 PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer June 3, 2025Contributors : Kyle A Cottrell ; Addison A YoungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC), the deadliest breast cancer subtype, lacks broadly applicable targeted therapies. Induction of ‘viral mimicry’ through activation of viral double-stranded RNA (dsRNA) sensors has potentia […]
- GSE298193 RNA-Seq analysis of rat pancreatic tissue from control and acute pancreatitis models June 3, 2025Contributors : Shiya Ma ; Zhiyu Han ; Xueying Ma ; Zhaojian Shen ; Weili YuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis study investigates gene expression changes in the pancreas of rats with acute pancreatitis induced by intraperitoneal injection of L-arginine (5mg/kg, 36 hours) compared to saline-injected […]
- GSE298422 Transcriptional analysis of developing Aspergillus fumigatus biofilms reveals metabolic shifts required for biofilm maintenance June 3, 2025Contributors : Charles Puerner ; Kaesi A Morelli ; Joshua D Kerkaert ; Jane T Jones ; Katherine G Quinn ; Sandeep Vellanki ; Robert A CramerSeries Type : Expression profiling by high throughput sequencingOrganism : Aspergillus fumigatusAspergillus fumigatus is a filamentous fungus found in compost and soil that can cause invasive and/or chronic disease in a […]
- GSE298342 Enhanced gliogenesis and delayed maturation underpin the neurodevelopmental defects in Lowe syndrome June 3, 2025Contributors : Yojet Sharma ; Priyanka Bhatia ; Gagana Rangappa ; Sankhanil Saha ; Padinjat RaghuSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThe activity of signaling pathways is required for coordinated cellular and physiological processes that lead […]
- GSE298448 Valproic acid inhibits Burkitt lymphoma by downregulating PFN2 expression to modulate the PI3K/AKT pathway June 3, 2025Contributor : Yongliang ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBurkitt lymphoma (BL) is a type of B-cell non-Hodgkin's lymphoma, which commonly occurs in children. At present, chemotherapy is the main treatment for BL, but CHOP treatment regimen has limited effectiveness, requiring precautions against […]
- GSE298453 Human umbilical cord MSCs prime monocytes to recruit and activate eosinophils for enhanced host defence against Klebsiella pneumoniae June 3, 2025Contributors : Ting Yu ; Yue Ming ; Yu GongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe global rise of antibiotic-resistant Klebsiella pneumoniae (KP) underscores an urgent need for novel preventive strategies. Although human mesenchymal stem/stromal cells (hMSCs) exhibit immunomodulatory and antimicrobial proper […]
- GSE298548 FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in Inflammatory Bowel Disease-Induced Bone Loss June 3, 2025Contributors : Haoming Wang ; Jiandong Guo ; Lijun Li ; Putao Yuan ; Zhiwei Jie ; Shunwu Fan ; Ziang XieSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusGut-bone axis is critical for body homeostasis, but bone loss often complicates inflammatory bowel disease (IBD) with unclear mechanisms. Here, we found that IBD mice s […]
- GSE268259 Plant U-Box 4 regulates chloroplast stress signaling and programmed cell death via Salicylic acid modulation June 3, 2025Contributors : Snigdha Rai ; Matthew D Lemke ; Anika M Arias ; Maria F Gomez Mendez ; Katayoon Dehesh ; Jesse D WoodsonSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaIn response to environmental stress, chloroplasts generate reactive oxygen species, including singlet oxygen (1O2), which regulates nuclear gene e […]