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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE240827 Provoking the Immunotherapy Efficacy of Renal Medullary Carcinoma [RNA-seq II] July 2, 2025Contributors : Zilong Zhao ; Benxia Hu ; Yalan Deng ; Melinda Soeung ; Jun Yao ; Tina K Nguyen ; Yaohua Zhang ; Zhou Jiang ; Jian Gao ; Shuang Peng ; Bora Lim ; Linghua Wang ; Qing Zhang ; Li Ma ; Leng Han ; Dihua Yu ; Michael Curran ; Giannicola Genovese ; Boyi Gan ; Wenbo Li ; Palvos Msaouel ; Liuqing Yang ; Chunru LinSeries Type : Expression profiling by […]
- GSE207434 Priming adult human hepatocytes as organoids for liver tissue engineering July 2, 2025Contributors : Sarah H Saxton ; Tara N McCray ; Kelly R StevensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile human hepatocytes in the adult liver perform hundreds of life-sustaining functions, culture methods to support their phenotype and function in vitro remain elusive. Here, we describe establishment of an o […]
- GSE269346 Modified Y RNA-derived fragments form a complex with YBX1 and PARP1 to promote DNA repair July 2, 2025Contributors : Annabelle Shaw ; Kamal Ajit ; Monika GullerovaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTo protect genome integrity from pervasive threats of damage and prevent diseases like cancer, cells employ an integrated network of signalling pathways called the DNA damage response. These pathways involve […]
- GSE253649 Temporal multi-omic profiling reveals chemoradiotherapy-specific dualistic metabolic rewiring that supports glioblastoma tumor recurrence July 2, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE274209 The effect of Sars CoV2 on 3d endometrial spheriods July 2, 2025Contributors : M Salker ; Y Singh ; M Camarena Sainz ; J AdmardSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExpression prolifing by high throughput sequencing
- GSE271505 Damage sensing through TLR9 Promotes Viral Clearance and Recovery During Influenza Infection July 2, 2025Contributors : Yifan Yuan ; Amy Zhao ; Lokesh SharmaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusToll-like receptor-9 is a pattern-recognition receptor that binds to the unmethylated CpG sequences in DNA. Its role in influenza infection is not well understood. Using mice deficient in TLR9, we demonstrated that these […]
- GSE300930 Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice alters adipokine secretion and improves cerebrovascular health July 2, 2025Contributors : Florine Seidel ; Martine C Morrison ; Ilse Arnoldussen ; Vivienne Verweij ; Joline Attema ; Christa de Ruiter ; Wim van Duyvenvoorde ; Jessica Snabel ; Bram Geenen ; Ayla Franco ; Maximilian Wiesmann ; Robert Kleemann ; Amanda J KiliaanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusVisceral white adipose […]
- GSE277347 Analysis of the transcriptomic changes of myoblasts lacking Daxx or both Daxx and Hira histone chaperones July 2, 2025Contributors : Virginia Zoglio ; Sarah Chebouti ; Fayez Issa ; Frederic Relaix ; Joana Esteves de LimaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDAXX, a H3.3 histone chaperone known for its role in heterochromatin maintenance, has been understudied in the context of gene expression regulation. In this study, we gen […]
- GSE301059 transglutaminase 2 (TGM2) and Its Novel Targeted Activator in Diabetic Bone Regeneration: From Mechanism to Application July 2, 2025Contributors : Dian Gan ; Xuan Li ; Faming ChenSeries Type : Non-coding RNA profiling by arrayOrganism : Rattus norvegicusTo screen and identify key molecule regulating T2DM (Type 2 diabetes mellitus)-impaired bone regeneration, cellular osteogenic potential and mitochondrial function, and to elucidate the regulatory mechanisms of this molecule. Microarray a […]
- GSE300996 Cancer-Associated Fibroblast-derived exosomal LINC02420 drives glycolytic reprogramming via AEG-1/HIF-1α to promote Laryngeal Cancer progression July 2, 2025Contributor : Yun LiSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensLaryngeal squamous cell carcinoma (LSCC) has an insidious onset and strong heterogeneity. The lack of effective biomarkers makes early diagnosis difficult. Liquid biopsy technology provides a new direction to break through this bottleneck. The co-culture model of CAFs a […]
- GSE301135 3'UTR-dependent activity of transcription factors and chromatin regulators [RNA-seq] July 2, 2025Contributors : Yang Luo ; Mervin Fansler ; Christine MayrSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOver 2700 human mRNAs have highly conserved 3'UTRs, but their biological functions are unknown. These mRNAs enrich for transcriptional regulators. Therefore, we performed RNA-seq to determine the roles of 3
- GSE301136 Roles of 3'UTR and IDR in regulating activity and chromatin localization of JMJD3 [ChIP-seq] July 2, 2025Contributors : Yang Luo ; Pierre-Jacques Hamard ; Richard Koche ; Christine MayrSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensJMJD3 cellular activity can be regulated by altered chromatin localization to genomic targets or by protein conformation changes that alter its catalytic activity. We found that t […]
- GSE301292 scRNAseq analysis of kidney treated with GLS1 inhibitor [scRNA-seq Kid_BPTES] July 2, 2025Contributors : Teh-Wei Wang ; Yuki T Okamura ; Makoto NakanishiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed the Chromium GEM-X single-cell RNA sequencing platform by 10x Genomics to investigate the effects of the GLS1 inhibitor, BPTES, on the kidney single-cell transcriptome of 19- to 20-month-old wild-ty […]
- GSE279612 FABP7 expression modulates the response of astrocyte to induced endotoxemia. July 2, 2025Contributor : Marcelo VargasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effect of knocking down FABP7 expression in a mouse model of endotoxemia
- GSE300902 Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control July 2, 2025Contributors : María J Pérez ; Rocío B Colombo ; Sebastián M Real ; María T Branham ; Sergio R Laurito ; Carlos T Moraes ; Lía MayorgaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensMitochondrial diseases, caused by mutations in either nuclear or mitochondrial DNA (mtDNA), currently have limited treatment options. For mtDNA m […]