Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE203635 Transcriptomics provides novel insights into the regulatory mechanism of Panax notoginseng exosome-like nanoparticles in HSF May 16, 2025Contributor : Zhaowei TengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn current study, we observed that Panax notoginseng exosome-like nanoparticles successfully inhibited apoptosis and promoted proliferation in HSF. Moreover, transcriptomics was implemented to uncover its underlying mechanism. A total of 7924 diff […]
- GSE231596 GI-SINE Analyses May 16, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE230719 AP-1 inhibition in DRG neurons by A-Fos dominant negative construct May 16, 2025Contributors : Michael Fainzilber ; Eitan ZahaviSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrior analysis suggsted that that AP-1 TFs play a role in expression of specific B2-SINE following in-vivo nerve injury. We thus sought to experimnetally test the role of AP-1 transcription factors in upregulation of B2-SINE […]
- GSE267474 BLIMP1 negatively regulates IL-2 signaling in T cells May 16, 2025Contributors : Suyasha Roy ; Warren J Leonard ; Tovah E Markowitz ; Neelam RedekarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIL-2 signaling sustains immune homeostasis by fine-tuning the balance between effector and regulatory T cells. Our genome-wide CRISPR knockout screen using IL-2-dependent cells derived from a […]
- GSE233824 Sciatic nerve crush regulation of RNA alternative poly-adenylation [DRGinjury_2019-QuantSeq_Rev_24h] May 16, 2025Contributors : Michael Fainzilber ; Indrek KoppelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPoly-adenylation regulates post-transcriptional processing and localization of mRNA. To study the effect of nerve injury on poly-adenylation across the transcriptome, 3'-end RNAseq was carried on DRG neurons following s […]
- GSE274098 Recurrent FGFR-alterations are frequent oncogenic drivers and therapeutic targets in pediatric low-grade gliomas May 16, 2025Contributor : Pratiti BandopadhayaySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE270443 Osteoclast-independent osteocyte dendrite defects in mice bearing the Osteogenesis Imperfecta-causing Sp7 R342C mutation May 16, 2025Contributors : Jialiang S Wang ; Marc N WeinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteogenesis imperfecta (OI) is a group of diseases caused by defects in type I collagen processing which result in skeletal fragility. While these disorders have traditionally been regarded as defects in osteoblast function, the […]
- GSE296967 CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation May 16, 2025Contributors : Eric G. Carlson ; Jennifer C. Lopez ; Yukiko Yamaguchi ; Jackson Gibson ; Saul J. Priceman ; Mark A. LaBargeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Aging is the greatest risk factor for breast cancer, and although epithelial cells are the source of carcinomas, epithelial changes alone […]
- GSE296943 Deciphering HAND Pathogenesis Using Single-Nucleotide Omics Approaches May 16, 2025Contributors : Michael Bukrinsky ; Dmitri Sviridov ; Tatiana Pushkarsky ; Anelia Horvath ; Siera MartinezSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlthough antiretroviral therapy (ART) effectively suppresses HIV-1 replication to undetectable levels […]
- GSE297277 Functional maps of a genomic locus reveal confinement of an enhancer by its target gene [Region-capture Micro-C (RCMC)] May 16, 2025Contributors : Mathias Eder ; Christina J Moene ; Mikhail Magnitov ; Jamie Drayton ; Elzo de Wit ; Anders S Hansen ; Bas van SteenselSeries Type : OtherOrganism : Mus musculusGenes are often activated by enhancers located at large genomic distances. The importance of this positioning is poorly understood. Here, by relocating different promoter-reporter const […]
- GSE297254 Multiplexed Self-Adaptable Janus Hydrogels Rescue Epithelial Malfunction to Shine Complete Trachea Repair May 16, 2025Contributors : Yi Chen ; Hai Tang ; Yan Zhang ; Lei Wang ; Jun Zhu ; Lele Wang ; Anqi Li ; Xiang Zeng ; Binyu Yin ; Yu Liang ; Xiulin Dong ; Ziyin Pan ; Qingfeng Bai ; Long Wang ; Lei Zhang ; Minglei Yang ; Yunlang She ; Weiyan Sun ; Kun Zhang ; Chang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusTo inves […]
- GSE297313 TIA1-mediated stress granules promote the neurodegeneration of motor neurons through sequestrating mRNA of heat shock protein HSP70 family in C9orf72-poly-GA mice May 16, 2025Contributors : Yan Wei ; Dongmei LI ; Rui Yang ; Yanzhu Liu ; Xuan Luo ; Weiqiao Zhao ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTIA1 knockout in the central nervous system (TIA1Nestin-CKO mice) alleviated motor neuron loss, neuroinflammation and motor dysfunction in C9orf72-poly-GA mice. Mechanistically, […]
- GSE297350 SOX9 is a driver of a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer [Unenriched_Tumor] May 16, 2025Contributors : Alexander J Duval ; Mazhar AdliSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to platinum-based chemotherapies remains a formidable challenge to the treatment of high-grade serous ovarian cancer (HGSOC). The complex and multifa […]
- GSE297400 Transcriptome Profiling of Human Dermal Fibroblasts Treated with 4 Phosphodiesterase Inhibitors Across Multiple Dose Gradients May 16, 2025Contributor : Wankyu KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study presents RNA-sequencing data from Human Primary Dermal Fibroblast, Neonatal (HDFn) cells treated with four phosphodiesterase (PDE) inhibitors—roflumilast, rolipram, cilostazol, and milrinone—across a 2-fold serial dilution range spanning […]
- GSE279526 Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies May 16, 2025Contributors : Valentine De Castro ; Oumaïma Abdellaoui ; Barbara Dehecq ; Babacar Ndao ; Alexandra Dauvé ; Olivier Adotévi ; Romain Loyon ; Yann GodetSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensT cell-based cancer therapies efficacy can be limited by the tumor microenvironment which can lead to T cell dysfunction. […]