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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE267503 GoldCLIP-seq analysis of RPL22HaloTag and RPL22L1HaloTag RNA-binding May 13, 2025Contributors : Wenjun Fan ; Hester Liu ; Marikki LaihoSeries Type : OtherOrganism : Homo sapiensRibosome biosynthesis is essential for cancer growth and proliferation. This dependency is therapeutically exploitable by blocking the rate-limiting step, RNA polymerase I (Pol I) transcription. Here we investigated the ability of RPL22 and RPL22L1 to interact wit […]
- GSE279383 Transcriptome profiles of RAW264.7 cells under fibroblast coculture with or without LPS sitimulation and tryptophan metabolites intervention May 13, 2025Contributors : Yihuang Huang ; Luyang Hong ; Shangyu Hong ; Yun CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA sequencing to identify the role of fibroblast in the effects of tryptphan metabolites on LPS-stimulated RAW264.7 cells.
- GSE267666 DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers May 13, 2025Contributors : Colm Doyle ; Krzysztof Herka ; Sean M Flynn ; Larry Melidis ; Somdutta Dhir ; David Tannahill ; Shankar BalasubramanianSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensEnhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer-prom […]
- GSE230615 Targeting CDK4/6 impairs RB1/E2F activity to overcome the resistance to selinexor in Nature killer/T-cell lymphoma May 13, 2025Contributors : Yali Wang ; Jianfeng Chen ; Yan Gao ; Jing TanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensXPO1 is frequently overexpressed in multiple hematological malignancies, highlighting the attractiveness of targeting XPO1 as a therapeutic strategy. However, the therapeutic potential of XPO1 inhibition in NKTL […]
- GSE204763 Multi-modal skin atlas associates a multicellular immune-stromal community with altered cornification and T cell expansion in atopic dermatitis [scRNAseq_VDJ] May 13, 2025Contributors : Evgenij Fiskin ; Gokcen EraslanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn healthy skin, a cutaneous immune system maintains balance between tolerance towards innocuous environmental antigens and immune responses against pathological agents, but in atopic dermatitis (AD), barrier and immune dysfunc […]
- GSE262238 Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiation (RNA-AMP-Seq) May 13, 2025Contributors : Ana C Raposo ; Paulo Caldas ; Maria Arez ; Joana Jeremias ; Simão da RochaSeries Type : OtherOrganism : Homo sapiensDuring culture, female human pluripotent stem cells (hPSCs), including human induced PSCs (hiPSCs) exhibit a propensity for erosion of X-chromosome inactivation (XCI). This phenomenon is characterized by loss of XIST RNA expressi […]
- GSE248110 RNA-seq analysis of human iPSC derived Hepatocyte organoids (iHOs), 2D-iPS-Heps, iPS-HPCs, iPSCs, and other iPSC derived organoids cultured in woBA medium and fetal organoid medium May 13, 2025Contributors : Taro Shimizu ; Masato Miyoshi ; Sei KakinumaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver has abundant regenerative capacity, but hepatocytes cannot be cultured long-term in vitro. Activation of FXR signaling induced iHOs with both hepatocyte traits and proliferative potential. To investigate the […]
- GSE296486 Tumor-derived Apolipoprotein E induces Tip endothelial cell to remodel tumor stroma ratio and promote pancreatic neuroendocrine tumor progression May 13, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA low tumor stroma ratio (TSR) in patients with pancreatic neuroendocrine tumors (pNETs) is associated with a significantly poorer tumor prognosis. However, current clinical trials have shown that administration of a single drug targeting a matrix component does not improv […]
- GSE296451 UBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors May 13, 2025Contributors : Iva Nikolic ; Joseph Cursons ; Nicholas D HuntingtonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInterleukin-15 receptor (IL-15R) agonists induce anti-tumor immunity in pre-clinical models, however, dose-limiting toxicity has hampered their clinical development. An alternative is to target pathways dow […]
- GSE296674 A new IDH-independent hypermethylation phenotype is associated with astrocyte-like cell state in glioblastoma May 13, 2025Series Type : Methylation profiling by arrayOrganism : Mus musculusDNA methylation plays a crucial role in cancer development and progression and has been linked to genetically and clinically distinct tumor classes, including IDH-mutated and IDH-wildtype adult-type diffuse gliomas. Here, we identified a CpG-island methylator phenotype (CIMP) that characteriz […]
- GSE296656 RNA seq of human colon cancer cell line HT29 treated with nanocurcumin May 13, 2025Contributors : Hewa Jalal Azeez ; Esmaeil Babaei ; Zohre ZibaeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study explores the transcriptomic effects of Gemini-curcumin (Gemini-Cur), a nano formulated version of curcumin, on HT-29 colorectal cancer cells. RNA sequencing was performed on treated and control sampl […]
- GSE296694 5R 16S rRNA Gene Sequencing Technology in Analyzing Blood Microbiota Structure in Patients with Acute Gastrointestinal Injury May 13, 2025Contributor : Jin WangSeries Type : OtherOrganism : Homo sapiensChanges in blood microbiota after AGI
- GSE296703 The novel ZBTB5::JAK2 fusion gene reveals a new mechanism of kinase activation in Ph-like acute lymphoblastic leukemia May 13, 2025Contributors : Qiang Qiu ; Juan Xu ; Tong Chen ; Ting LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPhiladelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a distinct subtype of B-ALL, exhibiting a kinase-activated gene expression profile similar to Philadelphia chromosome-positive (Ph+) ALL, yet […]
- GSE296744 Differentially expressed mRNA in biological premature ovarian insufficient (bPOI) May 13, 2025Contributors : Xue Jiao ; Nianyu Li ; Hanbing ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have completed the mRNA expression profiling of human granulosa cells to reveals the differentially expressed mRNAs involved in POI.
- GSE267501 RNA-seq analysis of RNA polymerase I inhibitor in p53 proficient HCT116 colon adenocarcinoma cells May 13, 2025Contributors : Wenjun Fan ; Hester Liu ; Marikki LaihoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRibosome biosynthesis is essential for cancer growth and proliferation. This dependency is therapeutically exploitable by blocking the rate-limiting step, RNA polymerase I (Pol I) transcription. Here we investigated the […]