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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE205304 NONO preferentially binds to exon-intron boundary and regulates alternative splicing in Rat Cardiac Fibroblasts May 12, 2025Series Type : Expression profiling by high throughput sequencingOrganism : RattusThis SuperSeries is composed of the SubSeries listed below.
- GSE236479 Bone marrow neutropoiesis bias underlies inflammatory comorbidities [smart_seq2] May 12, 2025Contributors : Yuman Li ; Yuting Niu ; Chenyu Deng ; Yue Yang ; Shiyu Sun ; Yao Li ; Yiming Chen ; Bo Hu ; Ying He ; Xuehui Zhang ; Wenwen Liu ; Yan Wei ; Mingming Xu ; Lili Chen ; Guojun Han ; Ying Huang ; Xuliang DengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLocal chronic inflammation exacerbates the prevalence […]
- GSE218052 Autophagy controls DNA accessibility to immunoglobulin variable regions and centroblast dynamics May 12, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE244080 OTUD3 prevents ulcerative colitis by modulating microbiota-mediated STING activation (part 5) May 12, 2025Contributors : Bo Li ; Taiki Sakaguchi ; Daisuke OkuzakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUlcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are suggested to play crucial roles in the pathogenesis of UC. However, the influences of the […]
- GSE244076 OTUD3 prevents ulcerative colitis by modulating microbiota-mediated STING activation (part 1) May 12, 2025Contributors : Bo Li ; Daisuke OkuzakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUlcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are suggested to play crucial roles in the pathogenesis of UC. However, the influences of the host-microbiota in […]
- GSE269379 The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy May 12, 2025Contributors : I-Na Lu ; Louisa Müller-Miny ; Oliver M Grauer ; Gerd Meyer zu HorsteSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensImmune effector cell-associated neurotoxicity syndrome (ICANS) is a significant complication of CAR T-cell therapy, affecting 20% to 70% of patients. Unraveling the mechanisms under […]
- GSE263245 Inducible intestinal epithelial knockout of PRMT1 in mouse model May 12, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMany studies investigated the mechanisms that control enteroendocrine cell (EEC) fate determination; however, regulation of EEC development and function are still unclear. Here, We performed RNA-Sequencing analyses on the small intestinal crypts of tamoxifen-inducible inte […]
- GSE296415 CircRNA expression profiling in plasma of early-stage lung adenocarcinoma patients and healthy controls May 12, 2025Contributor : Peini XueSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensThis study aimed to explore circRNA expression profiles in the plasma of patients with early-stage lung adenocarcinoma compared to healthy controls. Using Agilent microarray technology, we profiled total RNA extracted from plasma samples of 4 patients with early-stag […]
- GSE296109 Age-associated changes in the shell gland transcriptomics and eggshell quality of broiler breeder hens May 12, 2025Contributors : Prem L Mahato ; Vedbar Khadka ; Prafulla Regmi ; Ken Macklin ; Rajesh Jha ; Birendra MishraSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusThe egg production cycle of broiler breeder hens is comparatively shorter than laying hens, and as they age, their egg production and eggshell quality decline. The eg […]
- GSE296621 Polycomb repressive complex 2 regulates sexual development in Neurospora crassa May 12, 2025Contributors : Abigail M Deaven ; Abigail R Ameri ; Zachary A LewisSeries Type : Expression profiling by high throughput sequencingOrganism : Neurospora crassaIn most branches of the fungal kingdom sexual development marks a dramatic shift from simple multicellular hyphae to complex fruiting bodies composed of multiple tissues and cell types. It is essential […]
- GSE296557 The cell wall controls stem cell fate in the Arabidopsis shoot apical meristem May 12, 2025Contributors : Zerin Tasnim ; Ruiz-Duarte Paola ; Wolf SebastianSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaAt the basis of plant developmental plasticity are continuously active pluripotent stem cells, which fuel the life-long post-embryonic formation of new organs. Since plant cells are encased in cell wal […]
- GSE296700 Mitochondrial oxidative transport is inhibited by NDUFA4L2 to promote primary tumor escape [ATAC-Seq] May 12, 2025Contributors : Emily Arner ; W. Kimryn Rathmell ; Jeff RathmellSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMetastases cause most cancer deaths and reflect cellular transitions from epithelial to mesenchymal states (EMT) that enable primary tumor escape to seeding and growth at metastatic sites. Rare ca […]
- GSE296702 Mitochondrial oxidative transport is inhibited by NDUFA4L2 to promote primary tumor escape [RNA-Seq] May 12, 2025Contributors : Emily Arner ; W. Kimryn Rathmell ; Jeff RathmellSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetastases cause most cancer deaths and reflect cellular transitions from epithelial to mesenchymal states (EMT) that enable primary tumor escape to seeding and growth at metastatic sites. Rare cancer-driving m […]
- GSE296804 The transcriptomics of phenotypic nonspecificity in Drosophila melanogaster May 12, 2025Contributors : Gabriella A Sidhu ; Anthony Percival-SmithSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTranscription factor (TF) function is redundant as TF phenotypes are frequently rescued by TFs not resident to the TF locus, a phenomenon termed phenotypic nonspecificity. Phenotypic nonspecificity is not […]
- GSE296826 Raw RNA-sequencing data for deriving BCR sequences from the NIH U01 project: Finding the optimal balance of immunotherapy efficacy and toxicity. May 12, 2025Contributors : Yang Xie ; David GerberSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIrAEs convey substantial morbidity, incur considerable costs, and in some cases may preclude further use of immune checkpoint blockades. Recent studies indicate that (1) up to 80% of individuals on ICIs experience some form of irAEs; ( […]