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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE267037 MEF2D functions as a tumor suppressor in breast cancer May 8, 2025Contributors : Xiaoxia Wang ; He Shen ; Yanmin Chen ; Yali Zhang ; Jianmin Wang ; Song Liu ; Bo Xu ; Hai Wang ; Costa Frangou ; Jianmin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe myocyte enhancer factor 2 (MEF2) gene family plays fundamental roles in the genetic programs that control cell differentiation, […]
- GSE277624 CD163+ cardiac macrophages attenuate pressure overload-induced left ventricular systolic dysfunction via interleukin-10 May 8, 2025Contributors : Wei NI ; Binbin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground Chronic sustained pressure overload induces cardiac remodeling, which often leads to heart failure. Cardiac macrophages (cMacs) are heterogeneous cell populations, and their elimination has been shown to exacerbate pressure over […]
- GSE271676 Spatial Transcriptional Landscape of Human Heart Failure May 8, 2025Contributors : Sang E Lee ; Jeong H Joo ; Hee S Hwang ; Shang-Fu Chen ; Douglas Evans ; Kyoung Y Lee ; Kyung-Hee Kim ; Junho Hyun ; Min-Seok Kim ; Sung-Ho Jung ; Jae-Joong Kim ; Jeong S lee ; Ali TorkamaniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHeart failure (HF) poses a major clinical challenge with diverse und […]
- GSE296395 Comparative Study on the Effects of Silicon Nanoparticles and Cellulose Nanocrystals on Drought Tolerance in Tall Fescue (Festuca arundinacea Schreb.) May 8, 2025Contributors : Li Meng ; Hu Sile ; Bai Xulong ; Ren Jie ; Tian Kanliang ; Zhang Huili ; Zhang Zhilong ; Nguyen VanquySeries Type : Expression profiling by high throughput sequencingOrganism : Lolium arundinaceumTall fescue (Festuca arundinacea Schreb.) is a commonly used herbaceous species for slope ecological restoration in China. However, water scarcity of […]
- GSE280211 Gene expression profle at single cell level of lacrimal gland May 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe lacrimal gland (LG) is essential for tear secretion and plays a critical role in dry eye disease (DED). This study utilized single-nucleus RNA sequencing (snRNA-seq) to investigate the cellular diversity of the LG in both normal and DED conditions.
- GSE224484 A gatekeeper mechanism of the noradrenergic neural control of tear secretion via the NA-Adra1a-Ucp2 pathway May 8, 2025Contributors : Qun Wang ; Qingjun Zhou ; Lixin XieSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTears are mainly secreted from the lacrimal gland under precise controls by autonomic neural response to external sensory and psychogenic emotional stimulation. Dynamic volume and compositional changes of tears may lead to […]
- GSE203067 Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma May 8, 2025Contributors : Baifeng Zhang ; Yongxu Jia ; Yanru Qin ; Xinyuan GuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe profiled the transcriptome of 85, 263 single cells from ESCC patients with lymph node metastasis (LNM) and clustered 7, 196 myeloid cells into 18 subclusters including nine for macrophage cells, one for […]
- GSE293265 Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells [scRNA-seq] May 8, 2025Contributors : Swikriti Shrestha ; Lauren Jennings ; Kyle Knofczynski ; Sharath Shivakumar ; Quinn PetersonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysfunction of pancreatic alpha cells contributes to the pathophysiology of diabetes. Features of diabetic alpha cell dysfunction include glucagon hypersecretion, def […]
- GSE290503 RIT1 drives lung oncogenic transformation and is an actionable target in lung adenocarcinoma [PDX] May 8, 2025Contributors : Alessandro M Mozzarelli ; Yuzhe Niu ; Pau CastelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRIT1 is a small GTPase of the RAS family and RIT1 mutations have been identified in lung cancer, leukemias, and the developmental disorder Noonan syndrome. Mutations in RIT1 lead to increased levels of this onc […]
- GSE293267 Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells May 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE293266 Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells [Bulk RNA-seq] May 8, 2025Contributors : Swikriti Shrestha ; Lauren Jennings ; Kyle Knofczynski ; Sharath Shivakumar ; Quinn PetersonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysfunction of pancreatic alpha cells contributes to the pathophysiology of diabetes. Features of diabetic alpha cell dysfunction include glucagon hypersecretion, def […]
- GSE296155 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer [RNA-seq] May 8, 2025Contributor : Scott BestSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSmall cell lung cancer (SCLC) responds exceptionally well to cytotoxic chemotherapy. However, relapse with the emergence of chemoresistant disease is rapid and accompanied by poor treatment outcomes. To understand the genetic basis of chemoresistanc […]
- GSE296258 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer [CUT&Tag] May 8, 2025Contributor : Scott BestSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSmall cell lung cancer (SCLC) responds exceptionally well to cytotoxic chemotherapy. However, relapse with the emergence of chemoresistant disease is rapid and accompanied by poor treatment outcomes. To understand the genetic basis of […]
- GSE296261 Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer May 8, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE235814 Urine progenitor renal cells May 8, 2025Contributors : Josep M Cruzado ; Anna Sola ; Miguel L Pato ; Anna Manonelles ; Cristian Varela ; Fernando E Setien ; Carlos Quero-Dotor ; James S Herald ; David Pinyero ; Ana Amaya-Garrido ; Nuria Dolade ; Sergi Codina ; Carlos Couseiro ; Nuria Bolanos ; Montserrat Goma ; Fransesc Vigues ; Angelika Merkel ; Paola Romagnani ; Maria BerdascoSeries Type : Methy […]