Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286206 Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice April 14, 2025Contributors : Shuo He ; Yi Zhu ; Jinlong HeSeries Type : Expression profiling by high throughput sequencingOrganism : Disturbed shear stress-induced endothelial atherogenic responses are pivotal in the initiation and progression of atherosclerosis, contributing to the uneven distribution of atherosclerotic lesions. This study investigates the role of Aff3ir […]
- GSE282914 Targeting G9a Regulated m6A Modification Pathway to Hinder SARS-CoV-2 Replication April 14, 2025Contributors : John A Wrobel ; Adil Muneer ; Feng Zhang ; Xian ChenSeries Type : OtherOrganism : N6-methyladenosine (m6A) modification pathway is hijacked by several RNA viruses, including SARS-CoV-2, making it an attractive host-directed target for development of broad-spectrum antivirals. Here, we show that histone methyltransferase G9a, through its intera […]
- GSE200848 Tracheal aspirate single cell RNA sequencing from patients with ARDS [scRNA-seq] April 14, 2025Contributors : Aartik Sarma ; Charles R Langelier ; Carolyn S CalfeeSeries Type : Expression profiling by high throughput sequencingOrganism : Trachel aspirates samples were collected from an observational cohort of mechanically ventilated patients to compare respiratory tract gene expression in previous-descried ARDS molecular phenotypes. Patient charts wer […]
- GSE294540 Transcriptomic analysis of WT and Polg R292C/R292C lungs six hours after intratrachael instillation of Pseudomonas aeruginosa April 14, 2025Contributors : Phillip West ; Jordyn VanPortflietSeries Type : Expression profiling by high throughput sequencingOrganism : Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacteria […]
- GSE263944 Molecular characterisation of ameloblastoma with RNA-sequencing April 14, 2025Contributors : Constanza Marin ; Keith D Hunter ; Janine Kirby ; Akinyele O AdisaSeries Type : Expression profiling by high throughput sequencingOrganism : The aim of the study was to characterise the transcriptome profile of ameloblastoma in order to identify relevant genes involved in its pathogenesis by carrying out high-throughput gene expression.
- GSE229667 MapID-based Quantitative Mapping of Chemical Modifications and Expression of Human Transfer RNA April 14, 2025Contributors : Huiqing Zhou ; Mtichel Tepe ; Yitan Chen ; Allison CarsoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Transfer RNAs (tRNAs) carry abundant chemical modifications, and growing evidence shows dysregulation of chemical modifications on human tRNAs causes an expanding number of diseases including cancers, diabetes, […]
- GSE294258 Mitochondria iron transporter ABCB8 contributes to -7/del(7q) leukemia through regulating histone methylation April 14, 2025Contributors : Yiman Peng ; Jianan Zheng ; Xintong Deng ; Zhongwang WangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Chromosome deletions are common in human cancers and often correlate with poor prognosis. Tumor suppressor genes are enriched in these deleted reg […]
- GSE270239 Navigating the Cold: Integrative Transcriptome Sequencing Approach Reveals Ionoregulatory and Whole-Body Responses to Cold Acclimation in Drosophila ananassae April 14, 2025Contributors : Vera M Yilmaz ; Zhihui Bao ; Sonja GrathSeries Type : Expression profiling by high throughput sequencingOrganism : Understanding how species adapt to changing environments is a major goal in evolutionary biology and can elucidate the impact of climate change. Climate imposes inevitable effects on the geographical distribution of insects as the […]
- GSE294483 MeRIP-seq to identify putative Mettl3 targets in the nephron progenitor cells April 14, 2025Contributors : Vishal D Patel ; Harini RamalingamSeries Type : OtherOrganism : Mettl3 is an mRNA methyl transferase enzyme. It catalzyes the methylation of the most common mRNA biochemical modification N6-methyl adenosine (m6A). The role of Mettl3/m6A pathway is unknown in the developing kidney. Through genetic and pharmaceutical approaches we found that Met […]
- GSE294296 Cutaneous lupus features specialized stromal niches and altered retroelement expression April 14, 2025Contributor : Jeff R GehlhausenSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Single-cell RNA and spatial sequencing of lesional and non-lesional cutaneous lupus skin compared to healthy controls. The study includes 12 single-cell samples (cutaneous lupus patients with non-lesional (5) and lesional (4) skin biopsies with h […]
- GSE294500 PSME3 Regulates Migration and Differentiation of Myoblasts April 14, 2025Contributors : Kenneth D Kuhn ; Ukrae H Cho ; Martin W HetzerSeries Type : Expression profiling by high throughput sequencingOrganism : The acquisition of cellular identity requires large-scale alterations in cellular state. The non-canonical proteasome activator PSME3 is known to regulate diverse cellular processes, but its importance for differentiation re […]
- GSE294537 Transcriptomic analysis of WT and Polg D257A/D257A bone marrow derived macrophages (BMDMs) challenged with Pseudomonas aeruginosa April 14, 2025Contributors : Phillip West ; Jordyn VanPortflietSeries Type : Expression profiling by high throughput sequencingOrganism : Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacteria […]
- GSE294539 Transcriptomic analysis of WT and Polg D257A/D257A lungs six hours after intratrachael instillation of Pseudomonas aeruginosa April 14, 2025Contributors : Phillip West ; Jordyn VanPortflietSeries Type : Expression profiling by high throughput sequencingOrganism : Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacteria […]
- GSE277560 Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 April 14, 2025Contributors : Yo Han Lee ; Bukyung Baik ; Jang Hyun Choi ; Dougu NamSeries Type : Expression profiling by high throughput sequencingOrganism : The molecular mechanisms underlying the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remain largely unclear. Emerging evidence suggests that microRNAs (miRNAs) play a critical role […]
- GSE294219 Reprogramming deaminase substrate specificity for single nucleobase editing April 14, 2025Contributors : Wu Yuan ; Xiao Yulan ; Tang WeixinSeries Type : OtherOrganism : In this study, we set out to reprogram deaminase context specificity to pinpoint editing. We identified multiple nucleic acid-recognition hotspots in the E. coli tRNA-specific adenosine deaminase (TadA). Strategically sampling these recognition hotspots, we first accessed multipot […]