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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE229919 RBPMS in Heart Failure during aging April 16, 2025Contributors : Haobo Li ; Anthony RosenzweigSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the role of RBPMS in endothelial cells, endothelial cells were isoldated from 18-month-old mice hearts and treated with lentivirus expressing empty vector or lentivirus overexpressing RBPMS.We then performed gene e […]
- GSE229891 PARP9 in Heart Failure during aging April 16, 2025Contributors : Haobo Li ; Anthony RosenzweigSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the role of PARP9 in endothelial cells, endothelial cells were isoldated from 18-month-old mice hearts and treated with scrambled control or PARP9 siRNA gene knockdown.We then performed gene expression profiling an […]
- GSE263859 Multi-omics sequencing reveals the signature of the genome, cell composition and transcriptome of nodal RDD [scRNA-seq] April 16, 2025Contributors : Qiyang Shen ; Hanjun Yin ; Lifeng Zhu ; Chunlei Zhou ; Sirui Pan ; Nan Xie ; Xinyi Xia ; Jianfeng Zhou ; Tao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRDD is a poorly understood disease with low incidence. Here, we performed whole genome sequencing, single cell RNA-seq and spatial transcriptome se […]
- GSE250136 Integrated Molecular-Phenotypic Profiling Reveals Metabolic Control of Morphological Variation in Stembryos April 16, 2025Contributors : Alba V Luque ; Ryan G Savill ; Natalia Lopéz-Anguita ; Adriano Bolondi ; Sumit Garai ; Seher I Gassaloglu ; Aayush Poddar ; Aydan Bulut-Karslioglu ; Jesse V VeenvlietSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian stem-cell-based models of embryo development (stembryos) hold great promise in bas […]
- GSE264102 Type 1 Diabetes Human Enteroid Studies Reveal Major Changes In The Intestinal Epithelial Compartment April 16, 2025Contributors : Vishwesh Bharadiya ; Varsha Singh ; Mark DonowitzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap in the ma […]
- GSE263860 Multi-omics sequencing reveals the signature of the genome, cell composition and transcriptome of nodal RDD [ST] April 16, 2025Contributors : Qiyang Shen ; Hanjun Yin ; Lifeng Zhu ; Chunlei Zhou ; Sirui Pan ; Nan Xie ; Xinyi Xia ; Jianfeng Zhou ; Tao LiSeries Type : OtherOrganism : Homo sapiensRDD is a poorly understood disease with low incidence. Here, we performed whole genome sequencing, single cell RNA-seq and spatial transcriptome sequencing of a nodal RDD, describing its cell […]
- GSE264119 Metabolic shifts during growth deceleration in Drosophila imaginal wing discs April 16, 2025Contributors : Zhao Yifan ; Alexandre Cyrille ; Kelly Gavin ; Perez-Mockus Gantas ; Vincent Jean-PaulSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterGrowth during development is often characterised by progressive deceleration, as organisms, tissues, and organs approach their final size. Using transcriptomics […]
- GSE292886 Identification of novel genes and pathways in corneas post open field blast injury via transcriptomic analysis April 16, 2025Contributors : Rajnish Kumar ; Nishant R Sinha ; Suneel Gupta ; Ratnakar Tripathi ; Rajiv R MohanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aimed to investigate the transcriptomic alterations in the cornea following open-field blast injury (OFBI) for the first time via RNA sequencing (RNA-Seq) with the o […]
- GSE294212 The essential role of connective-tissue cells during axolotl limb regeneration April 16, 2025Contributors : Damián García-García ; Dunja Knapp ; Minjoo Kim ; Katelyn Jamwal ; Heath Fuqua ; Ryan P Seaman ; Riley E Grindle ; Sergej Nowoshilow ; Maria Novatchkova ; Fred W Kolling ; Joel H Graber ; Prayag MurawalaSeries Type : OtherOrganism : Ambystoma mexicanumAxolotls (Ambystoma mexicanum) are known for their remarkable limb-regeneration abilities, wh […]
- GSE294447 Neural representation of cytokines by vagal sensory neurons April 16, 2025Contributors : Tomás S Huerta ; Adrian C Chen ; Saher Chaudhry ; Aisling Tynan ; Timothy Morgan ; Kicheon Park ; Richard Adamovich-Zeitlin ; Bilal Haider ; Jian Hua Li ; Mitali Nagpal ; Stavros Zanos ; Valentin A Pavlov ; Michael Brines ; Theodoros P Zanos ; Sangeeta S Chavan ; Kevin J Tracey ; Eric H ChangSeries Type : Expression profiling by high throughpu […]
- GSE294678 Dietary restriction mitigates vascular aging, modulates the cGAS-STING pathway and reverses macrophage-like VSMC phenotypes in progeroid DNA-repair-deficient Ercc1Δ/- mice April 16, 2025Contributors : SJM Stefens ; J van der Linden ; JM Heredia-Genestar ; RMC Brandt ; S Barnhoorn ; N van Vliet ; I van der PluijmSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is a major risk factor for cardiovascular diseases and the accumulation of DNA damage significantly contributes to the aging process. This s […]