Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE201444 Single-Cell Transcriptome Atlas of Human Mesenchymal Stem Cells Derived from Umbilical Cords during Passaging April 17, 2025Contributor : Zheng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe immunosuppressive properties of mesenchymal stromal cells (MSCs) derived from umbilical cords have been clinically used to treat many clinical diseases, such as graft-versus-host disease (GVHD). Due to batch-to-batch variability, the obtained re […]
- GSE259331 A non-syndromic orofacial cleft risk locus links tRNA splicing defects to neural crest cell pathologies [RNA-seq] April 17, 2025Contributors : Michaela Bartusel ; Jade Varineau ; Alvaro Rada-Iglesias ; Eliezer CaloSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOrofacial clefts are the most common form of congenital craniofacial malformations worldwide. The etiology of these birth defects is multifactorial, involving genetic and environmental fa […]
- GSE252073 YAP targets TEAD4-NF-κB complex and inhibits ccRCC tumor growth II April 17, 2025Contributors : Zhongbo Li ; Miao YU ; Jian ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe prevalent understanding of Hippo signaling is one inhibitory pathway in tumor growth via deactivating the potential of YAP-TEAD transcriptional complex. The aberrant activation of YAP was observed in a series of human malig […]
- GSE262399 Long term exposure of PB-MP has no effect on the metabolism of mice April 17, 2025Contributors : Bokyung Kim ; Gyeong B Song ; Jeein Hong ; Gijeong Woo ; Mi J Choi ; Sungguan HongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroplastics are defined as plastics ranging in size from 0.1μm to 5mm. Currently, research is being conducted across various fields to examine the effects of microplastics. S […]
- GSE261725 Long term expousre of PS-MP has no effect on the metabolism of mice. April 17, 2025Contributors : Bokyung Kim ; Gyeong B Song ; Jeein Hong ; Gijeong Woo ; Mi J Choi ; Sungguan HongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroplastics are defined as plastics ranging in size from 0.1μm to 5mm. Currently, research is being conducted across various fields to examine the effects of microplastics. S […]
- GSE265881 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (ChIP-Seq) April 17, 2025Contributors : Rui Sun ; Robert FisherSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe RNA polymerase II (RNAPII) transcription cycle is regulated throughout its duration by protein phosphorylation. Previously, two regions phosphorylated by cyclin-dependent kinase 9 (CDK9) in elongation factor SPT5—the […]
- GSE264270 Menin is a Targetable Epigenetic Regulator in Glioblastoma (RNA-Seq) April 17, 2025Contributors : Yanhong Yang ; Yuhki SaitoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastomas (GBM) are highly lethal tumors that are refractory to treatment. Here we describe a novel approach to target the epigenetic landscape of GBM and destabilize the glioma progenitor program, leading to inhibition of tumor […]
- GSE294222 Spatial Visualization Provides Insight into Immune Modulation by an L-DBF Vaccine Formulation Against Shigella April 17, 2025Contributors : Ti Lu ; Skyler T Kramer ; Mary A York ; Mst Nusrat-Zahan ; Debaki R Howlader ; Zackary K Dietz ; Sean K Whittier ; Nathan J Bivens ; Alexander Jurkevich ; Lyndon M Coghill ; William D Picking ; Wendy L PickingSeries Type : OtherOrganism : Mus musculusShigellosis remains a global public health problem, especially in regions with poor sanitation […]
- GSE292234 mRNA expression profiling analysis in AGS cells after RBM8A knockdown [RNA-Seq] April 17, 2025Contributors : Hang Peng ; Chen Huang ; Jianhua WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we aimed to investigate the impact of RBM8A knockdown on mRNA expression in gastric cnacer cells. We used RNAi technology to specifically knock down RBM8A expression in AGS cells, establishing two experimen […]
- GSE294346 The essential role of connective-tissue cells during axolotl limb regeneration [Agilent] April 17, 2025Contributors : Damián García-García ; Dunja Knapp ; Minjoo Kim ; Katelyn Jamwal ; Heath Fuqua ; Ryan P Seaman ; Riley E Grindle ; Sergej Nowoshilow ; Maria Novatchkova ; Fred W Kolling ; Joel H Graber ; Prayag MurawalaSeries Type : Expression profiling by arrayOrganism : Ambystoma mexicanumThis experiment was performed to obtain an expression profiling of co […]
- GSE294241 T-cell dysfunction during blinatumomab therapy in pediatric acute lymphoblastic leukemia April 17, 2025Contributors : Julie Ma ; Annie Luong ; Andrew Doan ; Tsen-Yin Lin ; Lingyun Ji ; Cassandra Wang ; Seon-Jae Yoon ; Teresa Rushing ; Anh Duong ; Miguel Villa ; Chintan ParekhSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite the high response rate to the T-cell engager blinatumomab in B-cell acute lymphoblastic leuk […]
- GSE294689 Oncogenic transcription factor targets April 17, 2025Contributors : Otto Kauko ; Mikko Turunen ; Gong-Hong WeiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTranscription factors ERG and AR (prostate cancer), ER (breast cancer), CTNNB1 (colorectal cancer), GLI1 and PAX3-FOXO1 fusion (Rhabodomyosarcoma) have been shown to be critical for the formation of tumors. The purpose of this study was […]
- GSE294795 Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution April 17, 2025Contributors : Pacholko Anthony ; Schaeffer Samantha ; Santisteban Monica ; Wang Gang ; Faraco Giuseppe ; Racchumi Gianfranco ; Anrather Josef ; Iadecola CostantinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusArterial hypertension is a leading cause of cognitive impairment, attributed to hemodynamic insufficiency, bl […]
- GSE294815 Design and Biological Activity of a Novel Urea Compound Against Glioblastoma April 17, 2025Contributors : Frank Pajonk ; Ling HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite advances in surgery and radiotherapy, glioblastoma (GBM) remains the deadliest adult brain cancer with unacceptable low median survival rates. Targeted therapies and biologics have failed to improve outcome and the standard-of-c […]
- GSE294831 Design and Biological Activity of a Novel Urea Compound Against Glioblastoma [HK-374] April 17, 2025Contributors : Frank Pajonk ; Ling HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite advances in surgery and radiotherapy, glioblastoma (GBM) remains the deadliest adult brain cancer with unacceptable low median survival rates. Targeted therapies and biologics have failed to improve outcome and the standard-of-c […]