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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE264369 Fatty acid oxidation downregulation in alveolar epithelial 2 cells promotes acute lung injury in obesity April 18, 2025Contributors : E Kallinos ; Kuei-Pin Chung ; Lisa K Torres ; Divya Bhatia ; Baran Ersoy ; William Z Zhang ; Heather Stout Delgado ; Augustine M Choi ; Maria PlatakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is associated with increased risk for acute respiratory distress syndrome (ARDS). High fat diet induc […]
- GSE283964 Temporal Differences in Progenitor Metabolism Shape Regional Brain Growth during Development April 18, 2025Contributors : Awais Javed ; Natalia Baumann ; Denis JabaudonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian brain development is characterized by disproportionate forebrain expansion, yet the mechanisms underlying this regional growth specificity remain poorly understood. Here, we provide a single-cell-resolu […]
- GSE268121 RNA-seq Analysis of the Longissimus Muscle of Laiwu and Yorkshire Pigs April 18, 2025Contributors : Wen C Peng ; Jiang W WuSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaIntramuscular fat (IMF) content is the determining factor for meat taste. To reveal the genetic basis of IMF content, genetic studies have made some progress in lean-type pig breeds, but fewer studies have been conducted in Chinese fat-t […]
- GSE295024 Imlunestrant: A next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancer April 18, 2025Contributors : Shira Sherman ; Zachary Sandusky ; Douglas Russo ; Rinath JeselsohnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEstrogen receptor alpha (ER) is a critical driver of tumorigenesis and tumor progression in most breast cancers. Endocrine therapies targeting the ER are the cornerstone treatments in hormone […]
- GSE287596 Transcriptomic response of apple (Malus x domestica Bork. cv. Húsvéti rozmaring) shoot explants to in vitro cultivation on media containing thidiazuron or 6-benzylaminopurine riboside April 18, 2025Contributors : Dóra Farkas ; Viktor Ambrus ; Anita Király ; Neama Abdalla ; Judit DobránszkiSeries Type : Expression profiling by high throughput sequencingOrganism : Malus domesticaThe effects of two cytokinins (thidiazuron and 6-benzylaminopurine riboside), each applied at 4.5 μM, were studied on mRNA transcription of in vitro apple shoots. Transcriptomic […]
- GSE247154 A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci [RNA-seq] April 18, 2025Contributors : Abdou Akkouche ; Emma Kneuss ; Susanne Bornelöv ; Yoan Renaud ; Evelyn L Eastwood ; Jasper van Lopik ; Nathalie Gueguen ; Mingxuan Jiang ; Pau Creixell ; Stéphanie Maupetit-Mehouas ; Anna Sobieszek ; Yifan Gui ; Benjamin Czech Nicholson ; Emilie Brasset ; Gregory J HannonSeries Type : Expression profiling by high throughput sequencingOrganism […]
- GSE247150 A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci [CUT&RUN] April 18, 2025Contributors : Abdou Akkouche ; Emma Kneuss ; Susanne Bornelöv ; Yoan Renaud ; Evelyn L Eastwood ; Jasper van Lopik ; Nathalie Gueguen ; Mingxuan Jiang ; Pau Creixell ; Stéphanie Maupetit-Mehouas ; Anna Sobieszek ; Yifan Gui ; Benjamin Czech Nicholson ; Emilie Brasset ; Gregory J HannonSeries Type : Genome binding/occupancy profiling by high throughput seque […]
- GSE294410 The “play transcriptome” is sex-specific in the juvenile rat medial amygdala: a role for inhibitory neurons April 18, 2025Contributors : Ashley E Marquardt ; Mahashweta Basu ; Jonathan W VanRyzin ; Seth A Ament ; Margaret M McCarthySeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSocial play is a well-conserved, dynamic behavior known to be sexually differentiated. In most species, males play more than females, a sex difference largely […]
- GSE294399 Rare Subset of T Cells Form Integrin-dependent Clustering with Circulating Tumor Cells to Foster Metastasis in Breast Cancer April 18, 2025Contributors : David Scholten ; Andrew D Hoffmann ; Matthew Schipma ; Priyam Patel ; Ching Man Wai ; Huiping LiuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe immune ecosystem, particularly T cells, is central to maintaining effective anti-tumor responses. However, how immune cells in the periphery blood in […]
- GSE294611 TSG-6 activated MSC-derived Extracellular Vesicles present altered micro-RNA contents and ameliorate the inflammatory phenotype of macrophages in vitro April 18, 2025Contributors : Iker Martinez-Zalbidea ; Alyssa Rzasa ; Varun Puvanesarajah ; Wolfgang Hitzl ; Karin Wuertz‑KozakSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensMesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown promising immunomodulatory properties; however, strategies to enhance their therape […]
- GSE294498 Incorporating programmable DNA-binding domains enhances the efficiency and flexibility of miniature CRISPR base editors April 18, 2025Contributors : Qianyue Huang ; Geng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe therapeutic application of base editors is currently limited by their large sizes, which are often beyond the packaging capabilities of adeno-associated viral (AAV) vectors. Despite recent progress in mega genome mining that has id […]
- GSE294838 Sex-lethal is recruited to chromatin to promote neuronal tRNA synthesis in males through RNA Polymerase III regulation April 18, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Drosophila melanogasterThis SuperSeries is composed of the SubSeries listed below.
- GSE294906 Long non-coding RNA LOC401312 induces radiosensitivity through upregulation of CPS1 in non-small cell lung cancer April 18, 2025Contributors : Zhengyue Cao ; Tiantian Wang ; Fumin Tai ; Rui Zhai ; Hujie Li ; Xiaofei Zheng ; Changyan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong noncoding RNAs (lncRNAs), non-protein-coding transcripts exceeding 200 nu-cleotides, are critical regulators of gene expression through chromatin remodeling, tra […]
- GSE294910 Serotonin Gates Hippocampal VIP Interneuron Activation in Novelty Detection via Dual-Transmitter MnR Signaling April 18, 2025Contributors : Xiao Luo ; Dimitry Topolnik ; Justine Fortin-Houde ; Felix Michaud ; Benedicte Amilhon ; Lisa TopolnikSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe sequenced thirteen vasoactive intestinal peptide (VIP)-expressing interneurons from the mouse CA1 oriens/alveus area using patch-seq technique to determi […]
- GSE255799 Charaterization of potential roles and mechanisms of ACBP/DBI in NASH/MASH-dirven HCC mouse models April 18, 2025Contributor : Sijing LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe demonstrated that ACBP/DBI inhibition impaired hepatocarcinogenesis in NASH/MASH-driven HCC models. To further investigate its potential mechanisms at transcriptional level in NASH/MASH-driven HCC models, we performed Bulk RNA-seq analyses with li […]