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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE261037 Single-cell transcriptomic analysis of cell lines derived from a metaplastic breast cancer with squamous metaplasia (MBC-SM) tissue March 6, 2025Contributor : Huang-Chun LienSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough epithelial–mesenchymal transition (EMT) is the favored hypothesis for why cancer metastasis occurs, the cause–effect relationship remains unclear due to inconsistent clinical evidence. In this study, we establised epithelial– and mesen […]
- GSE261018 Urine Cell-Free RNA versus Plasma Cell-Free RNA for Monitoring of Immune and Urinary Tract Complications March 6, 2025Contributors : Omary Mzava ; Conor J Loy ; Isabel H Gonzalez-Bocco ; Liz-Audrey Djomnang Kounatse ; Andrew Bliss ; Sophia L Wells ; Joan Lenz ; Emma Belcher ; Kaiwen Chen ; Sophia Koo ; Lindsey R Baden ; Tinyi Chu ; Matthew P Cheng ; Jerome Ritz ; Iwijn De VlaminckSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile it […]
- GSE273987 Myrobalane fruit extracts modulate immunobiochemical pathways in vitro March 6, 2025Contributors : Stefanie Hofer ; Marcel Jenny ; Angela Klein ; Kathrin Becker ; Lucia Parrakova ; Florian Überall ; Markus Ganzera ; Dietmar Fuchs ; Hubert Hackl ; Pablo Monfort-Lanzas ; Johanna M GostnerSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe study investigates the effects of myrobalane fruit extracts, essential in Asian traditi […]
- GSE272257 Treatment of neurologic disorders by brain-wide microglia replacement using a non-conditioning strategy March 6, 2025Contributors : Li Zhong ; Dadian ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic evidence indicates that microglial dysfunctions contribute to the development and progression of various neurologic diseases, emphasizing microglia replacement as a promising therapeutic strategy. However, traditional bone marro […]
- GSE277840 Epigenetic Mapping of Cis-Regulatory Elements in the Developing Mouse and Pig Forelimbs. March 6, 2025Contributors : Ismael Sospedra-Arrufat ; Javier Lopez-Rios ; Gretel Nusspaumer ; Tena J JuanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculus ; Sus scrofaCis-regulatory elements (CREs) orchestrate the spatio-temporal regulation of key transcriptional programs. These elements - including promoters, enhancers […]
- GSE274097 Lung vascular ILC3s provide chemoattractant signals to recruit neutrophils during bacterial infection March 6, 2025Contributors : Yuefeng Huang ; Jiacheng Jin ; Wanwei Zhang ; Simon ShirleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile circulating leukocytes constantly patrol the body through blood-lymph circulatory network, tissue-resident immune cells such as innate lymphoid cells (ILCs) reside in the parenchymal compartmen […]
- GSE289751 Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction. March 6, 2025Contributors : Surabhi Gautam ; Pallavi BhattaramSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: We analyzed RNA-seq from fibroblast-like synoviocytes obtained from TNF induced inflammatory arthritis mice. Our goal was to evaluate the gene expression signatures after the cessation of inflammatory conditions. Me […]
- GSE290972 Impact of ATEVs and EV-DNA on transcriptional profile of dendritic cells in lymph nodes March 6, 2025Contributor : Mengying HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAntigen processing and presentation (APP) is essential for adaptive immunosurveillance in all nucleated cells. Here we describe a novel mechanism through which secreted factors other than cytokines, specifically extracellular vesicles (EVs) release […]
- GSE290312 The role of cholesterol/ALKBH1/ITGA2B in thrombosis in placental vessels of preeclampsia March 6, 2025Series Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensThe risk of multiple placental thrombosis is increased in preeclampsia (PE) and vascular endothelium plays vital roles in coagulation such as secreting ITGA2B, vWF and TF. However, the pathological mechanism is unclear. Placental blood vessels were collected from PE and n […]
- GSE290076 Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease. March 6, 2025Contributors : Peralta Ramos Javier ; Castellani Giulia ; Kviatcovsky Denise ; Croese TommasoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProtective immunity, essential for brain maintenance and repair, may be compromised in Alzheimer’s disease (AD). Here, using high-dimensional single-cell mass cytometry, we find a […]
- GSE290608 HIV-2 evolved ZAP resistance despite increased CpG levels March 6, 2025Contributors : Dorota Kmiec ; Rayhane Nchioua ; Alexander Gabel ; Asimenia Vlachou ; Sabina Ganskih ; Sümeyye Erdemci-Evin ; Stacey Lapp ; Diane Carnathan ; Steven Bosinger ; Ben Berkhout ; Atze T Das ; Mathias Munschauer ; Frank KirchhoffSeries Type : OtherOrganism : Homo sapiens ; Human immunodeficiency virus 2 ; Simian immunodeficiency virusSimian immunod […]
- GSE290889 Functional Analysis of Histone ZmH2B in Regulating Maize Resistance to Bipolaris maydis March 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Zea maysMaize histone ZmH2B belongs to the histone H2B family. In the current field of molecular biology, the majority of histone-related studies focus on their post-translational modification functions. However, studies specifically addressing histone H2B itself are relatively scarce […]
- GSE290952 IL22 supports Long-Term Expansion of Mouse and Human Hepatocytes in vitro. March 6, 2025Contributors : Bing Li ; Ren Guo ; Shitong Wang ; Xin XieSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusHepatocytes have wide applications in drug development, disease modeling, and cell therapy. However, to expand hepatocytes in large quantities in vitro without losing their functions remains a challeng […]
- GSE260976 Characterization of the genes that were regulated by infection with Malassezia furfur March 6, 2025Contributor : Eriko Kage-NakadaiSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansIn the present study, we investigated the pathogenicity of infection with Malassezia furfur using Caenorhabditis elegans as a model animal. The lifespan of the adult C. elegans infeted with Malassezia furfur was significantly longe […]
- GSE289606 Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination March 6, 2025Contributors : Gailleton Romain ; Mathew Nimitha ; Reusch Laura ; Schön Karin ; Scharf Lydia ; Strömberg Anneli ; Cvjetkovic Andrea ; Aziz Luaay ; Hellgren Johan ; Bemark Mats ; Tang Ka-Wei ; Angeletti DavideSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe nasal mucosa is the first immunologically active site that re […]