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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE281808 Enhancing single-cell ATAC sequencing with formaldehyde fixation, cryopreservation, and multiplexing for flexible analysis [ATAC-seq] July 1, 2025Contributors : Hohl Tobias ; Boenisch Ulrike ; Manke Thomas ; Arrigoni LauraSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe assay for transposase-accessible chromatin using sequencing (ATAC-seq) revolutionized the field of epigenetics since its emergence by providing a means to uncover chromatin dynami […]
- GSE279192 A 36-base hairpin within lncRNA DRAIC interacts with the IKKα coiled-coil domain, weakening the IKK complex and inhibiting NF-kappaB activation July 1, 2025Contributors : Xiaoxiao Hao ; Róża K Przanowska ; Chase A Weidmann ; Kevin M Weeks ; Anindya DuttaSeries Type : OtherOrganism : Homo sapiensLong noncoding RNAs have diverse functions, but not enough is known about the molecular mechanisms underlying their cellular functions. The 1.7 kb long down-regulated non-coding RNA in cancers (DRAIC) slows tumor growth […]
- GSE208599 A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth July 1, 2025Series Type : Expression profiling by high throughput sequencing ; Expression profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE133921 The spatial differences of root apex contribute to improved drought tolerance as induced by drought priming in wheat July 1, 2025Contributors : Xiao Wang ; Dong JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum aestivumDrought priming is a promising approach to improve drought tolerance, and root apex plays important role in coping with drought adversities in plants. It has been observed that less inhibition of root growth under drought stress wa […]
- GSE262997 An amino acid integration in the heat receptor ELF3 Molecular mechanism of temperature signal regulating plant growth July 1, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaIn Arabidopsis, ELF3, ELF4 and LUX proteins form the EC complex. The EC complex binds directly to the promoters of PIF4 and PIF5 in vivo, thereby inhibiting PIF4 and PIF5 expression at night. PIF4, as a key transcription factor for light and temperature, binds to t […]
- GSE243145 Characterization of residual cancer by comparison of a pair of organoids established from a patient with ESCC before and after neoadjuvant chemotherapy (in vitro) July 1, 2025Contributors : Yoshiyuki Tsukamoto ; Takafumi Fuchino ; Shusaku Kurogi ; Tomotaka Shibata ; Shoichi Fumoto ; Naoki HijiyaSeries Type : Expression profiling by arrayOrganism : Homo sapiensNeoadjuvant chemotherapy (NAC) followed by surgery is a standard approach for management of locally advanced esophageal squamous cell carcinoma (ESCC). Patients who do not r […]
- GSE301246 Plasticity of regulatory grammar in human promoters uncovered by MPRA-trained deep learning July 1, 2025Series Type : OtherOrganism : Homo sapiensOne of the major challenges in genomics is to build computational models that accurately predict genome-wide gene expression from the sequences of regulatory elements. Promoters play a key role in gene regulation, yet their regulatory logic remains incompletely understood. Here, we present PARM, a cell-type specific […]
- GSE271637 Impacts of Glut1 Deficiency and High Glucose Exposure on Transcriptomic Profiling in Human Brain Microvascular Endothelial Cells July 1, 2025Contributors : Zhi Fang ; Wenquan Hu ; Xiang Wang ; Qing R MiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used RNA-seq analysis to determine the alteration of transcriptomic profiling in human brain microvascular endothelial cells
- GSE301276 Human cerebral organoids model tumor initiation and infiltration in an autologous astrocyte-supported setting [RNA-Seq] July 1, 2025Contributors : Tamara Bender ; Esther Schickel ; Insa S SchroederSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEfforts to efficiently target brain tumors are constrained by the dearth of appropriate models to study tumor behavior towards treatment approaches as well as potential side effects to the surrounding normal […]
- GSE301272 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival [ATAC-seq] July 1, 2025Contributors : Thomas L Ekstrom ; Steven A JohnsenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, […]
- GSE301277 Human cerebral organoids model tumor initiation and infiltration in an autologous astrocyte-supported setting [snRNA-seq] July 1, 2025Contributors : Tamara Bender ; Esther Schickel ; Insa S SchroederSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEfforts to efficiently target brain tumors are constrained by the dearth of appropriate models to study tumor behavior towards treatment approaches as well as potential side effects to the surrounding normal […]
- GSE301283 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival [RNA-Seq] July 1, 2025Contributors : Thomas L Ekstrom ; Steven A JohnsenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, most tumors ar […]
- GSE301284 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival [ChIP-Seq] July 1, 2025Contributors : Thomas L Ekstrom ; Steven A JohnsenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, […]
- GSE273591 Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s disease -- Early-stage AD July 1, 2025Contributors : Kevin S Chen ; Mohamed H Noureldein ; Eva L FeldmanSeries Type : OtherOrganism : Mus musculusAlzheimer's disease (AD) exhibits imbalance between neuronal excitation and inhibition, likely secondary to interneuron dysfunction. To reveal underlying mediators, we profiled the transcriptome of neuronal subtypes in 5XFAD versus control mice at […]
- GSE301217 Lifestyle shapes premorbid social and microglial deficits in an Alzheimer’s disease mouse model July 1, 2025Contributors : Fanny Ehret ; Birte Doludda ; Hang Liu ; Sindi Nexhipi ; Hao Huang ; Fabian Rost ; Annette E Rünker ; Rupert W Overall ; Warsha Barde ; Michael Sieweke ; Andreas Dahl ; Mirko H Schmidt ; Gerd KempermannSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study we used a knock-in mouse model of Alzheime […]