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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE305310 miRNA-Seq of Extracellular Vesicles from Human Placenta–Derived Mesenchymal Stem Cells November 3, 2025Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensExtracellular vesicles (EVs) released by human placenta–derived mesenchymal stem cells (hpMSCs) are thought to mediate paracrine effects. To characterize their small-RNA cargo, we isolated hpMSC-derived EVs (hpEVs) from conditioned media using size-exclusion chromatogr […]
- GSE281154 mRNA transcriptome sequencing of tumor cells, TRMs, MDMs, Monocytes and CD8+ T cells from tumor lungs of KrasLSL-G12D/+Lkb1fl/fl (KL), KrasLSL-G12D/+Lkb1fl/flGpx4m/m(KLG4) after Ad-cre injection and tamoxifen treatment November 3, 2025Contributors : Peng Wang ; Shengdan Zhang ; Xin Chen ; Dandan Lin ; Bo ZhongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcriptional profiling of tumor cells, TRMs, MDMs, Monocytes and CD8+ T cells from tumor lungs of KL and KLG4 mice
- GSE261266 TPO stimulation midulates gene expression of iKMT2A-MLLT3 HSPC November 3, 2025Contributors : Hugues-Etienne Chatel-Soulet ; Jürg Schwaller ; Athimed El TaherSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInvestigate the immediate impact of in vivo exposure to exogenous TPO on gene expression,
- GSE152864 RNAseq of mRNA from hepatic CD8 T cell populations after low dose and during high dose AdV infection November 3, 2025Contributors : Verena König ; Miriam Bosch ; Nina Kallin ; Sainitin Donakonda ; Rupert Oellinger ; Thomas Engleitner ; Percy A KnolleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe aimed at dissecting phenotype, functionality and regulation of antigen-specific hepatic CD8 T cells after low dose or during high dose in […]
- GSE275332 MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription (RNA-Seq) November 3, 2025Contributors : Jun Y Sonn ; Marta Iwanaszko ; Ali Shilatifard ; Huda Y ZoghbiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss-of-function mutations in methyl-CpG binding protein 2 (MECP2) cause the neurodevelopmental disorder, Rett syndrome (RTT). The molecular mechanisms underlying MeCP2 function remain poorly unde […]
- GSE273186 Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease November 3, 2025Contributors : Junwei Liu ; Manuel Rogg ; Katharina Moos ; Shaya Sasanpour ; Vera Strassl ; Manaswita Jain ; Sato Magassa ; Björn Neubauer ; Benedikt Kloos ; Simone Braeg ; Benedikt Saller ; Svenja Wöhrle ; Frank Bienaimé ; Oliver Gorka ; Melanie Boerries ; Amandine Viau ; Olaf Gross ; Christoph Schell ; Wolfgang KuehnSeries Type : Expression profiling by hi […]
- GSE296893 Persistent pneumococcal colonisation in anti-retroviral-treated HIV infection is associated with nasal inflammation November 3, 2025Contributors : Joseph Aston Phiri ; Kondwani Charles JamboSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed a single cell RNA sequencing approach to study the nasal immune and epithelial cells landscape in People Living with HIV (PLHIV) and during the course of anti-retroviral uptake. The landscape ansal […]
- GSE277340 Transcriptomic Profiling Reveals the Role of Hedgehog Signaling as a Biomarker and in the Pathogenesis of Ménétrier’s Disease November 3, 2025Contributors : Miyoung Shin ; Tryston T Gabriel ; Fred Kwame Ofosu ; Jiali Zhang ; Tricia T Wang ; Matthew E Bechard ; Robert J Coffey ; Won Jae HuhSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBoth Ménétrier’s disease (MD) and juvenile polyposis syndrome (JPS) are rare premalignant conditions that can lead to gastric […]
- GSE299140 The ORB2 RNA-binding protein represses translation of its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding ‘ZZ’ domain November 3, 2025Contributors : Timothy CH Low ; Hua Luo ; Chalini Weerasooriya ; Sichun Lin ; Stephane Angers ; Craig A Smibert ; Howard D LipshitzSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterRNA-binding proteins (RBPs) are key components of the post-transcriptional regulatory machinery. We show that the ORB2 RBP, the Dro […]
- GSE299109 The ORB2 RNA-binding protein represses translation of its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding ‘ZZ’ domain November 3, 2025Contributors : Timothy C Low ; Hua Luo ; Chalini Weerasooriya ; Sichun Lin ; Stephane Angers ; Craig A Smibert ; Howard D LipshitzSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterRNA-binding proteins (RBPs) are key components of the post-transcriptional regulatory machinery. We show that the ORB2 RBP, the Dros […]
- GSE299661 The ORB2 RNA-binding protein represses translation of its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding ‘ZZ’ domain November 3, 2025Contributors : Timothy C Low ; Hua Luo ; Chalini Weerasooriya ; Sichun Lin ; Stephane Angers ; Craig A Smibert ; Howard D LipshitzSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterRNA-binding proteins (RBPs) are key components of the post-transcriptional regulatory machinery. We show that the ORB2 RBP, the Dros […]
- GSE300606 MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1 November 3, 2025Contributors : Farah Kobaisi ; Alicia Maugein ; Alexis Fouque ; Olivier Albagli-Curiel ; Philippe Ravassard ; Raphael ScharfmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA highly specific mosaic transcriptional environment guides the fate of pancreatic progenitors during development and next maintains the identity […]
- GSE305309 Human Placenta–Derived Mesenchymal Stem Cells Attenuate Hippocampal Aging-Associated Transcriptomic Profiles in Aged Mice November 3, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground Intravenous human placenta–derived mesenchymal stem cells (hpMSCs) can improve tissue function through paracrine effects, but their impact on normal brain aging is not well defined. Methods Aged female mice (18–19 months) received three intravenous infusions of […]
- GSE281010 PRC1 Mediates the Transcriptional Repressive Function of POGZ in Neurodevelopmental Gene Regulation November 3, 2025Contributors : Jessenia Chavez ; Zhonghua Gao ; James StaffordSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPolycomb Repressive Complex 1 (PRC1) is a family of fundamental epigenetic regulators crucial for gene silencing and mammalian development. Elucidating the PRC1 composition and function in context- and stage-spe […]
- GSE294561 YTHDF3 Promotes the Translation of m6A-Enriched Mitosis-Associated Genes to Attenuate the Responsiveness to Neoadjuvant Chemotherapy in Esophageal Cancer [RIP-seq] November 3, 2025Contributors : Xiang Y Wang ; Ting wang ; Si M Zhao ; Zi G DongSeries Type : OtherOrganism : Homo sapiensNeoadjuvant chemotherapy (NACT) is a pivotal treatment strategy for esophageal cancer, significantly improving patient prognosis and 5-year survival rates. However, a substantial proportion of patients exhibit resistance to NACT and consequently fail to b […]