Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE186544 Transcriptomic analyses of hMADS cells depleted for hormone-sensitive lipase October 25, 2025
  Contributors : Emeline Recazens ; Jeremy Dufau ; Dominique Langin ; Claire Naylies ; Yannick LippiSeries Type : Expression profiling by arrayOrganism : Homo sapiensHormone-sensitive lipase HSL is a major metabolic enzyme of adipocyte as the rate limiting enzyme of lipolysis. Recently, a non enzymatic role of HSL as been described in the regulation of the Car […]
• GSE216552 RNA sequencing analysis of wild-type and ITF2357 or I-BET151 or JQ1 treated mouse pancreatic cancer KPC cells October 25, 2025
  Contributors : Xiongbin Lu ; Zhuolong ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe ITF2357, I-BET151 and JQ1 promote antigen presentation and sensitize pancreatic cancer to T cell cytotoxicity, in combination with Immune checkpoint blockage therapy suppress tumor cell growth
• GSE216511 Spatiotemporal characterization of human early intervertebral disc formation at single-cell resolution October 25, 2025
  Contributors : Taifeng Zhou ; Yu Chen ; Zhiheng Liao ; Ren Xu ; Peiqiang SuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusIntervertebral disc (IVD) performs as a fibrocartilaginous joint to anchor adjacent vertebrae (VB) and is essential for the mechanical stabilization of axial skeleton. Although several studi […]
• GSE280288 Effect of LPS induced inflammation on placenta [RNA-Seq] October 25, 2025
  Contributor : Myoungseung KwonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effect of maternal inflammation during pregnancy on placenta, we injected LPS to pregnant dams at embryonic day 14 and analyzed gene expression.
• GSE246438 Novel lipid nanoparticle adjuvants vaccine for porcine reproductive and respiratory syndrome (PRRS) using in-vitro macrophage assays October 25, 2025
  Contributors : Aderonke Ayanniyi ; Bhavjinder K Dhillon ; Adrienne Nagy ; Robert E Hancock ; Volker Gerdts ; Ellen WasanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA novel triple adjuvant (TriAdj) platform formulated in various cationic lipid nanoparticles (L-TriAdj) was tested in-vitro for use in porcine reproducti […]
• GSE280478 Human PXR signaling enhances ethanol-induced liver injury in females October 25, 2025
  Contributors : Sarah Kim ; Julia Cui ; Maxwell GyamfiSeries Type : Expression profiling by arrayOrganism : Mus musculusAlcohol-associated liver disease (ALD) results from excessive alcohol consumption and is more severe in females. The prenane X receptor (PXR), a xenobiotic nuclear receptor essential for toxin defense, has been implicated in ALD, but the und […]
• GSE280289 Effect of matenral immune activation on lung immune cells during house dust mite induced allergic inflammation. [scRNA-Seq] October 25, 2025
  Contributor : Myoungseung KwonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the effect of maternal inflammation during pregnancy on allergic reactions in offspring, we inoculated house dust mite and ovalbumin into offspring born to either control or LPS induced maternal immune activation dams and analyz […]
• GSE286235 Construction of Human nucleus basalis Organoids and Cholinergic Projections in nbM-cortical Assembloids October 25, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe nucleus basalis, also known as the nucleus basalis of Meynert (nbM), which is considered to be one of the major cholinergic output of basal forebrain, have been found to dynamically modulate activity in the cortex. Dysfunction of nucleus basalis-cortical cholinergic ci […]
• GSE286912 Neuronal hyperactivity becomes mTORC1 independent due to epigenetic changes in Tuberous Sclerosis Complex October 25, 2025
  Contributors : Wardiya Afshar-Saber ; Juan Ruiz ; Isabel Gisser ; Ziqin Yang ; Leena Mehendale ; Nicole Teaney ; Madison Glass ; Truc Pham ; Elizabeth Bainbridge ; Mustafa Sahin ; Kellen WindenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTuberous Sclerosis Complex (TSC) is caused by variants in either TSC1 or TSC2, w […]
• GSE286949 Neuronal hyperactivity becomes mTORC1 independent due to epigenetic changes in Tuberous Sclerosis Complex [RNA-seq] October 25, 2025
  Contributors : Wardiya Afshar-Saber ; Juan Ruiz ; Isabel Gisser ; Ziqin Yang ; Leena Mehendale ; Nicole Teaney ; Madison Glass ; Truc Pham ; Elizabeth Bainbridge ; Mustafa Sahin ; Kellen WindenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTuberous Sclerosis Complex (TSC) is caused by variants in either TSC1 or TSC2, w […]
• GSE292766 Neural stem cell-derived extracellular vesicles inhibit microglial dysfunction in depression through targeting miR-16-5p/Cxcr4 axis October 25, 2025
  Contributors : Jialin C Zheng ; Xiaohuan Xia ; Xiangyu Li ; Meng Shi ; Yi Wang ; Congcong Li ; Tiantian Zhao ; Shengyang Fu ; Kailing Jia ; Xinrui Qi ; Jie Zhu ; Yanyan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeural stem cell-derived extracellular vesicles (NSC-EVs) have emerged as promising candidates for […]
• GSE303675 The E3 ubiquitin ligase LTN1 downregulates RNF10 level and uS3 ubiquitination October 25, 2025
  Contributors : Yuxi Huang ; Satoshi Hashimoto ; Sota Ito ; Chisato Kikuguchi ; Miho Hoshi ; Kiyoshi Yamaguchi ; Yoichi Furukawa ; Toru Suzuki ; Toshifumi InadaSeries Type : OtherOrganism : Mus musculusDuring gene expression, ribosome stalling frequently occurs and can lead to detrimental effects on cellular homeostasis. Several quality control mechanisms, in […]