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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291337 Hijacking innate immunity to enhance mRNA therapeutics March 25, 2026Contributors : Shu Meng ; Tinghong Zhang ; Jinling Qin ; Xing PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe therapeutic success of in vitro-transcribed (IVT) mRNA depends on its stability and efficient translation. However, IVT mRNA is highly susceptible to immune-mediated degradation, limiting its efficacy. H […]
- GSE292965 Features of Group 3-like medulloblastoma mouse model [scRNA-Seq] March 25, 2026Contributor : Han ZouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGroup 3 medulloblastoma is the most aggressive among the four medulloblastoma subgroups, with poor prognosis and early metastasis making treatment particularly challenging. The lack of an immune-competent mouse model has hindered effective in vivo test […]
- GSE292953 5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins March 25, 2026Contributors : Lindsey Hayes ; Benjamin Zaepfel ; Lauren Duan ; Anne Starner ; Mason Bartels ; Rebekah Rothacher ; Sophie Martin ; Rachel French ; Zhe Zhang ; Irika Sinha ; Jonathan Ling ; Shuying Sun ; Yuna Ayala ; Jeff Coller ; Eric Van Nostrand ; Liliana Florea ; Petr KalabSeries Type : OtherOrganism : Homo sapiensTDP-43, an essential nucleic acid binding […]
- GSE312740 Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model March 25, 2026Contributor : Jan R DetrezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusAdeno-associated virus (AAV)-based gene therapy for severe neurological diseases is challenged by immune responses, which are difficult to study accurately in genetically divergent rodent models or in in vitro human iPSC-derived mic […]
- GSE308298 Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning March 25, 2026Contributors : Mikhail D Magnitov ; Elzo de WitSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensMost genetic variants in the human genome reside in non-coding regions, where they can perturb regulatory elements, influence gene expression, and contribute to various phenotypes and diseases. However, i […]
- GSE262631 Histone Variant H2A.J is a Key Epigenetic Regulator in Human Trophoblast Development [Ribodepleted HS MM] March 25, 2026Contributors : Tyler Jensen ; Liangwen Zhong ; Andrew Xiao ; Berna Sozen ; Zongliang JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe preimplantation development in eutherian mammals is diverse. However, ethical and technical constraints significantly limit our understanding of the molecular and biochemical path […]
- GSE325824 The processed data of mrpl13 mutant and sibling. (zebrafish) March 25, 2026Contributor : Xinkai ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe liver is the largest metabolic organ in the human body, performing functions as metabolism, secretion, immunity, and detoxification. Due to the high energy demand, liver cells are rich in mitochondria. Mitochondrial homeostasis is crucial for l […]
- GSE325554 Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain [Spatial Transcriptomics] March 25, 2026Contributors : Anna Csiszar ; Zoltan Ungvari ; Roland Patai ; Tripti Gautam ; Tamas KissSeries Type : OtherOrganism : Mus musculusChemotherapy-induced cognitive impairment ("chemobrain") is a frequent side-effect in cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX-induced cognitive impairment remain obscure, and th […]
- GSE325553 Comparative transcriptomic profiling of human 3D endometrial stromal organoids under distinct decidualization stimuli March 25, 2026Contributors : Shichao Liu ; Yubing Liu ; Jiyang Zhang ; Tingjie Zhan ; Qiang Zhan ; Nataki Douglas ; Xiaoqin Ye ; Shuo XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndometrial stromal decidualization is a hormone-regulated process essential for establishing uterine receptivity and supporting embryo implantation. […]
- GSE325591 High-Resolution Profiling of Osteocyte Transcriptomes via Single-Nucleus RNA Sequencing March 25, 2026Contributors : Yukiko Kitase ; Jia Ji ; Lynda Bonewald ; Matthew Prideaux ; Hyun Cheol Roh ; Gang PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe developed a protocol for snRNA-seq on bone tissue, achieving high-yield recovery of osteocyte nuclei from snap-frozen, marrow-flushed long bones. This approach minimize […]
- GSE325586 Single-nucleus RNA-seq of mouse cortex during mid-gestation pregnancy March 25, 2026Contributors : Luca Fusar Bassini ; Dogukan H Ulgen ; Giovanni D'Angelo ; Gioele La MannoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-nucleus RNA sequencing (snRNA-seq) was performed on cortical tissue from non-pregnant and pregnant (embryonic day E13.5) female C57BL/6JRj mice (~12 weeks old) to character […]
- GSE325639 Construction and Evaluation of an Acid-Responsive Antibacterial Coating with Laser-Induced Micro/Nano-Structured Titanium Surface Loaded LAMA3 pDNA@ZIF-8 Nanoparticles for Enhanced Soft Tissue Integration March 25, 2026Contributors : Qiang Miao ; YiFei Zhang ; ChuFan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnlike natural teeth, dental implants exhibit distinct peri-implant structures characterized by only about one-third of the hemidesmosomal attachments and the absence of periodontal ligament fiber insertion, which compromi […]
- GSE325730 The genotoxic stress sensor ZBP1 drives tau pathology March 25, 2026Contributors : Jessica M Thanos ; Olivia C Campbell ; Nick R Natale ; Ana Royo Marco ; Michael A Puchalski ; John R LukensSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo gain a more comprehensive and unbiased assessment of how ZBP1 signaling affects microglial, astrocytic, and neuronal biology in tauopathy, we perfor […]
- GSE325731 Elucidating Salinity Stress and Engineered Solutions on Trichloroethene Bioremediation using a Consortium containing Dehalococcoides mccartyi March 25, 2026Contributor : Mohan SunSeries Type : Expression profiling by high throughput sequencingOrganism : Dehalococcoides mccartyiGroundwater salinization threatens contaminant bioremediation worldwide, yet how syntrophic microbial consortia—central to these processes—respond to salinity stress remains poorly understood. Using a defined trichloroethene-dechlorinatin […]
- GSE263015 MicroRNA expression profiling of synovial fluid in early and late Osteoarthritis and comparison with Rheumatoid Arthritis March 25, 2026Contributors : Diksha Rana ; Jyotdeep KaurSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensThis study employed miRNA microarray profiling to characterize differential expression patterns in synovial fluid samples (n=14) obtained from patients with osteoarthritis across different disease stages, as well as from patients with rheumatoid ar […]