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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE243467 MiR-19b-1 drives gestational hypoxia-Induced pulmonary hypertension through NADPH oxidases September 17, 2025Contributors : Yishi Qin ; Katharina Hochkogler ; Laura Zelarayan-Behrend ; Federico Bleckwedel ; Gabriela Salinas ; Andreas Petry ; Agnes GörlachSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGestational hypoxia can lead to intrauterine growth restriction and programming of cardiovascular diseases in adulthood via dif […]
- GSE273761 Analyze the transcriptional signature of kidney glomerular cells in mice September 17, 2025Contributors : Maria E Melica ; Giulia Carangelo ; Benedetta Mazzinghi ; Laura LasagniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPodocytes and podocyte progenitors are interdependent components of the kidney's glomerular structure, with podocytes forming the glomerular filtration barrier and progenitors being […]
- GSE269513 Allele-specific genomics decodes gene targets and mechanisms of the non-coding genome September 17, 2025Contributors : Tim Hasenbein ; Daniel AndergassenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA substantial proportion of disease variants reside in non-coding RNAs (ncRNAs), which serve as important regulatory elements. However, most ncRNA targets remain unknown, hindering our understanding of complex diseases. We f […]
- GSE278158 A protective role of SRC-1 against aging associated cognitive decline September 17, 2025Contributors : Jonathan C Bean ; Yongjie Yang ; Hari K Yalamanchili ; Chunmei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mechanisms underlying dementia, including Alzheimer’s Disease (AD), associated with aging remain elusive. Our RNA sequencing analysis (RNA-Seq) revealed that the loss of steroid receptor […]
- GSE276538 Exploring the Functional Role of Programmed Death-Ligand 1 (PD-L1) in the Castration-Resistant Prostate Cancer Using Transcriptomic Sequencing September 17, 2025Contributors : Lin Zhong ; Pengxin Zhang ; Jun Mao ; Lianhong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProstate cancer is one of the principal malignancies threatening human health, and the development of castration resistance often constitutes a major cause of treatment failure in its management. To elucidate […]
- GSE287537 Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and stage specific gene expression September 17, 2025Contributors : Dandan Hu ; Xuan Li ; Jiayi Huang ; Yue He ; Xueqin Zou ; Hongbin Si ; Xun Suo ; Xingju SongSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Toxoplasma gondiiThe SWI/SNF complex is evolutionarily conserved across species, initially identified in yeast, […]
- GSE281650 DNA topoisomerase II promotes N6-adenosine mRNA methylation [RNAseq] September 17, 2025Contributors : Clara Megías-Fernández ; Irene Delgado-Sainz ; Alberto León-Halcón ; Valentina Buglioni ; Federica Bruno ; Cristina González-Aguilera ; Magdalena M Maslon ; Silvia Jimeno-GonzálezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTopoisomerase II (TOP2) is an enzyme that regulates of DNA topology, primarily […]
- GSE308219 IFNgamma-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy September 17, 2025Contributors : Payal Goala ; Eduardo Cortes Gomez ; Jianmin Wang ; Prashant Singh ; Marco DavilaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCAR-T (Chimeric antigen receptor T cell) therapy has led to significant improvements in patient survival. However, a subset of patients experience high-grade toxicities, includi […]
- GSE308057 Essentiality and dynamic expression of the human tRNA pool during viral infection September 17, 2025Contributors : Noa Aharon-Hefetz ; Michal Schwartz ; Noam Stern-Ginossar ; Orna Dahan ; Yitzhak PilpelSeries Type : OtherOrganism : Homo sapiensHuman viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegalovirus (HCMV) an […]
- GSE308254 Self-assembly of hybrid 3D cultures by integrating living and synthetic cells September 17, 2025Contributors : Nils Piernitzki ; Gilles Gasparoni ; Oskar StauferSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSelf-assembly is a fundamental property of living matter that drives the three-dimensional (3D) organization of cell collectives such as tissues and organs. Here, the co-assembly of synthetic and natural cell […]
- GSE308238 A novel oncolytic neutrophil phenotype is induced by IL-10R inhibition [CITE-seq] September 17, 2025Contributors : Danny Nejad Khalil ; Ricardo Gomez ; Amit Regev ; Fadi Samaan ; Yacine Marouf ; Sadna Budhu ; Daniel Hirschhorn ; Isabell Schulze ; Jessica A. Lavery ; Nicholas Ceglia ; Samuel Freeman ; Vivien I. Maltez ; Jaynia Garcia ; Nathan Suek ; Chien-Huan (Gil) Weng ; Christopher R. Cabanski ; Sébastien Monette ; Yevgeniy Romin ; Yanyun Li ; Ronan Chal […]
- GSE308261 Interactions between gamma-delta T lymphocytes and M-MDSC cells in the pathogenesis of chronic lymphocytic leukemia September 17, 2025Contributor : Michal ZarobkiewiczSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-seq of zoledronate-expanded Vdelta2 gamma-delta T cells from healthy donors, cultured alone or co-incubated with myeloid-derived suppressor cells (M-MDSC) or vitamin C. The study investigates how M-MDSC influence gamma-delta T-cell func […]
- GSE308297 A Ternary-code DNA Methylome Atlas of Mouse Tissues September 17, 2025Contributors : Sol Moe Lee ; David C Goldberg ; Cameron Cloud ; Jared B Parker ; Christopher Krapp ; Christian E Loo ; Elliot Kim ; Ivan Zhao ; Chengcheng Jin ; Rishi Porecha ; Marisa S Bartolomei ; Rahul M Kohli ; Wanding ZhouSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusDNA cytosine modifications, including 5-methy […]
- GSE308338 Mast cell tryptase induces nuclear remodeling in breast cancer cells and has a negative impact on breast cancer cell growth September 17, 2025Contributors : Filip Panos ; Laura Bub ; Débora Parrine ; Aida Paivandy ; Anna-Karin Olsson ; Gunnar Pejler ; Fabio Rabelo MeloSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMast cells are known to accumulate in breast cancer, but there is only limited knowledge of how they may impact on breast cancer gro […]
- GSE189998 Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis September 17, 2025Contributors : Stefan Bittner ; Katrin Pape ; Tobias Bopp ; Matthias KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to assess the role of the CD5-CK2-STAT3 signalling axis in human pro-inflammatory Th17 cells. Blockade of CD5 reduced production of IL-17A, IFN-γ and GM-CSF by Th17-polarised cells w […]