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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE244415 The CGG triplet repeat binding protein 1 counteracts DNA secondary structure formation to prevent transcription-replication stress February 1, 2025Contributors : Henning Ummethum ; Florian Erhard ; Stephan HamperlSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCGGBP1 has been implicated in transcription regulation. We tried to investigate the molecular mechanism of how transcription is regulated by depletion of CGGBP1 protein.
- GSE225916 Genome-wide characterization of fragile and resistant nucleosomes in response to cold stress in maize [RNA-seq] February 1, 2025Contributors : Wenli Zhang ; Ranran Huang ; Yining ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysDistinct nucleosome architectures decode key regulatory information related to various cellular processes. However, how fragile (Fra-Nus) and resistant (Res-Nus) nucleosomes, with sensitivity and resistance to MNase cleavag […]
- GSE254969 Transcriptional profiling of lungs from SARS-CoV-2-infected K18-hACE2 mice February 1, 2025Contributors : Alexander Bukreyev ; Fuchun Zhou ; Shailendra ChauhanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the effects of SARS-CoV-2 proteins on expression of host genes in lung of infected mice, 4 groups of K18-hACE2 mice (4 mice per group) were mock-infected or infected cells with SARS-CoV-2 WT or […]
- GSE252582 Context-specific requirements of Tet enzymes in the modulation of CD8 effector and memory cell fates during acute viral infection [Cut&Tag] February 1, 2025Contributor : Priya D IssureeSeries Type : OtherOrganism : Mus musculusIn response to infections, naïve CD8 T cells give rise effector and memory T cells. However, eliciting long-lived memory CD8T cells remains a challenge for many infections. DNA demethylation of cytosines within CpG dinucleotides by Tet enzymes is a key epigenetic mechanism that regulate t […]
- GSE27385 The effects of fenofibrate and fish oil on gene expression in peripheral blood mononuclear cells, muscle, and adipose tissue from overweight and obese individuals [PBMC] February 1, 2025Contributors : Marjolijn C Bragt ; Mark V Boekschoten ; Michael Müller ; Ronald P MensinkSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe molecular effects of the non-selective dietary PPARalpha agonists n-3 LCPUFAs were compared side-by-side with those of the selective synthetic PPARalpha agonist fenofibrate on whole-genome gene express […]
- GSE255848 Tie2 activation relieves lymphedema by improving lymphatic endothelial integrity [Human RNA-seq] February 1, 2025Contributors : Bo-Yoon Park ; Il-Kug KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aim of this study was to evaluate genetic differences between lymphedema patient and normal using NGS-derived transcriptase profiling (RNA-seq) and quantitative reverse transcriptase chain reaction (qRT-PCR) methods in human fat […]
- GSE288152 Transcriptional changes of spermatogenic cells by Tex10 deficiency February 1, 2025Contributors : Feifei Yuan ; Jianlong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTestis-specific transcript 10 (Tex10) is highly expressed in the testis, embryonic stem cells (ESCs), and primordial germ cells (PGCs). We previously generated a Tex10 knockout mouse model demonstrating its critical roles in ESC pl […]
- GSE178639 Primary cilia, transition zone protein B9d1 is required for proper cell growth and ribosome biogenesis during meiotic prophase in males February 1, 2025Contributors : Hosu Sin ; Dan Lu ; Margaret T FullerSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTo investigate how primary cilia or ciliary signaling pathway(s) influence gene expression profile during meiotic prophase in male flies, we used RNA-seq from testes of B9d1 Knock-down, Tektin-C Knock-down, Klp […]
- GSE288169 Intrapulmonary metastases of non-small cell lung cancer promoted by a hotspot gain-of-function mutation in KMT2C February 1, 2025Contributors : Yiman Peng ; Yucui Shang ; Yuying WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer cells can spread from their original sites to both other organs and other sites within the same organs. One example of the latter is the intrapulmonary metastasis (IPM) of lung cancer, which is associated with poo […]
- GSE288153 Tex10 in day2 embryonic bodies (EBs) February 1, 2025Contributors : Feifei Yuan ; Jianlong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTestis-specific transcript 10 (Tex10) is highly expressed in the testis, embryonic stem cells (ESCs), and primordial germ cells (PGCs). We previously generated a Tex10 knockout mouse model demonstrating its critical roles in ESC pl […]
- GSE288185 TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability February 1, 2025Contributor : Matthew TaliaferroSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe subcellular localization of hundreds of RNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for the vast majority of these RNAs, the mechanisms that govern their lo […]
- GSE288186 Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development February 1, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE288202 RNA-seq data from tomato young inflorescence segregating for fruit weight QTL fw2.3 February 1, 2025Contributors : Lei Zhang ; Esther van der KnaapSeries Type : Expression profiling by high throughput sequencingOrganism : Solanum lycopersicum var. cerasiformeA novol fruit weight QTL fw2.3 was identified in tomato populaiton developed from a cross between two semi-domesticated SLC accession: BGV006768 and BGV007931. The effect of fw2.3 was observed in ovari […]
- GSE219125 m6A modification governs the stability of both methylated and unmethylated mRNA isoforms across the transcriptome February 1, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE288151 Transcriptional changes of Tex10 in purified primordial gem cell-like cells (PGCLCs) at day2 and day6 February 1, 2025Contributors : Feifei Yuan ; Jianlong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTestis-specific transcript 10 (Tex10) is highly expressed in the testis, embryonic stem cells (ESCs), and primordial germ cells (PGCs). We previously generated a Tex10 knockout mouse model demonstrating its critical roles in ESC pl […]