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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE277455 PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencing. [WGS] July 11, 2025Contributors : Gianluca Mattei ; Marta Baragli ; Barbara Gega ; Alessandra Mingrino ; Martina Chiechia ; Gianmaria Frigè ; Luca Mazzarella ; Francesco De Logu ; Romina Nassini ; Pier Giuseppe Pelicci ; Alberto MagiSeries Type : OtherOrganism : Homo sapiensIn epigenetic analysis, identifying differentially methylated regions (DMRs) typically involves detectin […]
- GSE208056 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons [4C] July 11, 2025Contributors : Xiaonan Guan ; Charles H Li ; Rudolf Jaenisch ; X S LiuSeries Type : OtherOrganism : Homo sapiensRett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of MECP2. Reactivation of the silent wild-type MECP2 allele on the inactive X chromosome (Xi) represents a promising therapeutic opport […]
- GSE302266 PHLOWER - Single cell trajectory analysis using Decomposition of the Hodge Laplacian [multiome] July 11, 2025Contributors : Mingbo Cheng ; Jitske Jansen ; Christoph Kuppe ; Rafael Kramann ; Ivan G CostaSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo dissect nephrogenic differentiation trajectories in kidney organoids using the multiome pipeline, organoids we […]
- GSE255579 CRISPR screens identify EXO1 as a therapeutic target for cancers with Fanconi anemia pathway and BRCA1-A complex deficiencies [PM22329] July 11, 2025Contributors : Marija Maric ; Tyler Stanage ; Simon BoultonSeries Type : OtherOrganism : Homo sapiensEXO1 is a conserved multi-functional exonuclease that performs roles in mismatch repair, homologous recombination, nucleotide excision repair, translesion DNA synthesis, resection of stalled replication forks and processing of Okazaki fragments. However, EXO1 […]
- GSE208258 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons July 11, 2025Series Type : Other ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE272708 Control of stem cell activity by CSLD5-mediated cell wall remodelling. July 11, 2025Contributors : Miao Lan ; Yangxuan Liu ; Weibing YangSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTo investigate the molecular mechanisms of CSLD5-mediated control of stem cell activity, the inflorescence meristems of wild-type, csld5, and complemented plants grown under the same conditions were dissected for […]
- GSE272086 Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol synthesis and storage July 11, 2025Contributors : Zhongchi Li ; John BlenisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCholesterol performs multiple essential roles in cells. Enhanced cholesterol synthesis and storage in lipid droplets have been linked to cancer aggressiveness, particularly in lipid-rich and hormone-sensitive cancers such as prostate […]
- GSE300585 Thor: a platform for cell-level investigation of spatial transcriptomics and histology [Heart Failure] July 11, 2025Contributors : Pengzhi Zhang ; Weiqing Chen ; Guangyu Wang ; Lai LiSeries Type : OtherOrganism : Homo sapiensSpatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic analysis, lacking integrated image interpretation. To address this, we present Thor, a comprehensive platform for cell-level analysis […]
- GSE299485 Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth July 11, 2025Contributors : Surajit Sinha ; Alexei Lobanov ; Michael Kelly ; Anna Lee Fong ; Jonathan HernandezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo form overt metastases, disseminated tumor cells must simultaneously acquire nutrients, circumvent oxidative stress, and evade organ-specific innate immune surveillance upon […]
- GSE302029 Pharmacological Manipulation of Nested Oscillations in Human iPSC-Derived 2D Neuronal Networks July 11, 2025Contributors : Anne G Bang ; Alexander T WootenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeural networks, formed by synchronized oscillatory bursts of activity across large populations of neurons, are fundamental to human cognition and behavior, and disrupted in neurodevelopmental disorders. Yet, mechanisms drivin […]
- GSE300692 Thor: a platform for cell-level investigation of spatial transcriptomics and histology [Bladder Cancer] July 11, 2025Contributors : Pengzhi Zhang ; Weiqing Chen ; Guangyu Wang ; Fotis Nikolos ; Keith Syson ChanSeries Type : OtherOrganism : Homo sapiensSpatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic analysis, lacking integrated image interpretation. To address this, we present Thor, a comprehensive platfo […]
- GSE302152 Multiple intron motifs have redundant functions in trans-splicing of the mod(mdg4) locus July 11, 2025Contributor : Maxim TikhonovSeries Type : OtherOrganism : Drosophila melanogasterIn contrast to canonical cis-splicing, trans-splicing combines exons from two distinct transcripts, yielding chimeric mRNAs. This process is typically suppressed through the tight coupling of pre-mRNA synthesis and splicing, primarily due to the inherent risk of generating chime […]
- GSE302164 Integration of multiomics reveals the mechanism of Lycium barbarum polysaccharides inhibit MCF-7 cell proliferation July 11, 2025Contributors : Li y Ding ; Yi t Shang ; Zhen Zhang ; Hong Yang ; Yu Deng ; Tian T He ; Guo q Yang ; Jia x Ma ; Xu f Fu ; Xing DuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground：Breast cancer, as a highly prevalent malignant tumor among women, has a consistently high mortality rate due to metastasis and drug re […]
- GSE302264 PHLOWER - Single cell trajectory analysis using Decomposition of the Hodge Laplacian [Xenium] July 11, 2025Contributors : Mingbo Cheng ; Jitske Jasen ; Christoph Kuppe ; Rafael Kramann ; Ivan G CostaSeries Type : OtherOrganism : Homo sapiensWe performed multiplex siRNA knockdown experiments of the identified neuronal lineage defining TFs PAX3, RFX4 and ZIC2 in kidney organoids in iPSC derived kidney organoids during the differentiation process from day 19 onwards […]
- GSE277453 PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencing.[RNA-Seq] July 11, 2025Contributors : Gianluca Mattei ; Marta Baragli ; Barbara Gega ; Alessandra Mingrino ; Martina Chiechia ; Gianmaria Frigè ; Luca Mazzarella ; Francesco De Logu ; Romina Nassini ; Pier Giuseppe Pelicci ; Alberto MagiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn epigenetic analysis, identifying differentially methylat […]