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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE297295 Apelin as a CNS-specific Pathway for Fenestrated Capillary Formation in the Choroid Plexus July 11, 2025Contributors : Lukas Herdt ; Stefan Baumeister ; Jeshma Ravindra ; Luca Sagcob ; Jean Eberlein ; Christian HelkerSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe cerebral vasculature consists of a heterogenous network of blood vessel, including barrier-forming capillaries with blood-brain-barrier (BBB) properties and […]
- GSE272098 Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder [snRNA] July 11, 2025Contributors : Song Bryan ; Kwon Min Jee ; Nicolella AllySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. To determine the neurobiological functions of AKAP11 and the consequenc […]
- GSE208056 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons [4C] July 11, 2025Contributors : Xiaonan Guan ; Charles H Li ; Rudolf Jaenisch ; X S LiuSeries Type : OtherOrganism : Homo sapiensRett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of MECP2. Reactivation of the silent wild-type MECP2 allele on the inactive X chromosome (Xi) represents a promising therapeutic opport […]
- GSE207885 Genome-wide gene expression of Yarrowia lipolytica wild-type and mutant(△pex10 harboring DGA1 overexpression plasmid) with or without 1 g/L hexanoic acid July 11, 2025Contributors : Sungmin Hwang ; Yeon-Ho Choi ; Sun-Mi LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Yarrowia lipolyticaThe goals of this study are to compare NGS-derived transcriptome profiling (RNA-seq) of Yarrowia lipolytica wild-type and mutant(△pex10 harboring DGA1 overexpression plasmid) upon treatment of mock and 1 g/L he […]
- GSE208258 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons July 11, 2025Series Type : Other ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE208221 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons [ChIP-Seq] July 11, 2025Contributors : Junming Qian ; Xiaonan Guan ; Charles H Li ; Rudolf Jaenisch ; X S LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of MECP2. Reactivation of the silent wild-type MECP2 allele o […]
- GSE280175 Molecular Cartography of the Human and Mouse Down Syndrome Brain [snRNA-seq] July 11, 2025Contributors : Min Yi Feng ; Wuxinhao Cao ; Gen Li ; Bharti Kukreja ; Nareh Tahmasian ; Bianca Rusu ; Ji-Young Youn ; Brian T KalishSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo gain molecular insight into the prenatal neurobiology of DS, we performed single-nucleus sequencing, spatial transcriptomics, and proteomi […]
- GSE271714 miRNA microarray expression from glioblastoma & astrocytes under 100V/m 48hr dcEF stimulation & sham July 11, 2025Contributors : Hsieh-Fu Tsai ; Amy Q ShenSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructDirect current electric field mimicking a physiological electrical field from transepithelial potential difference can direct cell migration (electrotaxis)and cellular signaling. While the transcriptome in dcEF has been reporte […]
- GSE286999 Base-resolution profiling of 5-glyceryl-methylcytosine in Chlamydomonas reinhardtii via DEA-sequencing [RNA-seq] July 11, 2025Contributors : Fanchen Wang ; Baodan He ; Zixin Wang ; Weiying Meng ; Yutao Fu ; Wanyue Zou ; Shuxia Sun ; Keyao Zhao ; Haoming Jiang ; Zhiyan Sun ; Jianhuang XueSeries Type : Expression profiling by high throughput sequencingOrganism : Chlamydomonas reinhardtii5gmC (5-glyceryl-methylcytosine), a vitamin C-derived hypermodified base, was identified in the ge […]
- GSE280177 Molecular Cartography of the Human and Mouse Down Syndrome Brain [MERFISH] July 11, 2025Contributors : Wuxinhao Cao ; Gen Li ; Bharti Kukreja ; Nareh Tahmasian ; Bianca Rusu ; Ji-Young Youn ; Brian T KalishSeries Type : OtherOrganism : Mus musculus ; synthetic constructGiven the importance of linking human and model system pathobiology, we also performed highly multiplexed RNA in situ spatial transcriptomics on a well-established trisomic mouse […]
- GSE287000 Base-resolution profiling of 5-glyceryl-methylcytosine in Chlamydomonas reinhardtii via DEA-sequencing [WGBS] July 11, 2025Contributors : Fanchen Wang ; Baodan He ; Zixin Wang ; Weiying Meng ; Yutao Fu ; Wanyue Zou ; Shuxia Sun ; Keyao Zhao ; Haoming Jiang ; Zhiyan Sun ; Jianhuang XueSeries Type : Methylation profiling by high throughput sequencingOrganism : Chlamydomonas reinhardtii5gmC (5-glyceryl-methylcytosine), a vitamin C-derived hypermodified base, was identified in the g […]
- GSE290862 Genetic disruption of the baculum compromises the ability of male mice to copulate [scRNA-seq] July 11, 2025Contributors : Caleb R Ghione ; Nicholas G Schultz ; Sungdae Park ; Douglas B Menke ; Matthew D DeanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe baculum, a bone in the penis of many mammal species, shows an astonishing level of morphological divergence between species. Despite hundreds of years of interest, biolo […]
- GSE290863 Genetic disruption of the baculum compromises the ability of male mice to copulate [ChIP-seq] July 11, 2025Contributors : Caleb R Ghione ; Nicholas G Schultz ; Sungdae Park ; Douglas B Menke ; Matthew D DeanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe baculum, a bone in the penis of many mammal species, shows an astonishing level of morphological divergence between species. Despite hundreds of years of i […]
- GSE272097 Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder [bulkSeq] July 11, 2025Contributors : Song Bryan ; Nicolella AllySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. To determine the neurobiological functions of AKAP11 and the consequences of its absen […]
- GSE280170 Molecular Cartography of the Human and Mouse Down Syndrome Brain [Slide-seq] July 11, 2025Contributors : Min Yi Feng ; Wuxinhao Cao ; Gen Li ; Bharti Kukreja ; Nareh Tahmasian ; Bianca Rusu ; Ji-Young Youn ; Brian T KalishSeries Type : OtherOrganism : Homo sapiensTo gain molecular insight into the prenatal neurobiology of DS, we performed single-nucleus sequencing, spatial transcriptomics, and proteomics on mid-gestational prenatal human brain ti […]