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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE288025 RAD51 family factors remodel the NHEJ system to modulate stress-induced biosynthesis of diterpenoid phytoalexins in rice. January 30, 2025Contributors : Zhan Xu ; Mingnan Qu ; Jemaa EssemineSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaDouble-strand break (DSB) damage are primarily repaired via homologous recombination (HR) and non-homologous end joining (NHEJ) in Eukaryotes. We reveals that HR subcomplex RAD51A1-RAD51C in rice (Oryza sativa L.) inhibit […]
- GSE218859 ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats [RRBS] January 30, 2025Contributors : Dahlet Thomas ; Dumas Michael ; Weber Michael ; Grillo Giacomo ; Velasco GuillaumeSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusZBTB24 has emerged as a key player in DNA methylation, immunity and development. To explore these multiple facets of ZBTB24 functions, we performed and integrated multi-omics […]
- GSE195741 GPR34 senses myelin debris to promote neuroinflammation and pathology January 30, 2025Contributors : Rongbin Zhou ; Zonghui Huang ; Xiaqiong Wang ; Bolong LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSterile neuroinflammation is a major driver of multiple neurological diseases. Myelin debris, which is released from the damaged myelin sheaths during demyelination, can act as an inflammatory stimulus […]
- GSE243907 Diversifying cerebrovascular endothelial cells during Zebrafish Blood-Brain Barrier Development January 30, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe cerebrovascular system plays pivotal roles in brain development and maintaining its functions. Despite several single-cell transcriptomic studies investigating the molecular atlas of brain vasculature, the comprehensive gene expression profile of the entire spectrum fro […]
- GSE218866 ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats [RNA-Seq] January 30, 2025Contributors : Velasco Guillaume ; Grillo GiacomoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusZBTB24 has emerged as a key player in DNA methylation, immunity and development. To explore these multiple facets of ZBTB24 functions, we performed and integrated multi-omics analyses in mouse and human cellul […]
- GSE254785 miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [PAR-CLIP] January 30, 2025Contributors : David L Turner ; Markus Bitzer ; Huanqing Zhang ; Deborah WalterSeries Type : OtherOrganism : Homo sapiensIn this study, we evaluated genetic mouse models of inducible renal epithelia-specific miR-17~92 loss-of-function and gain-of-function using unilateral ureteral obstruction. We utilized PAR-CLIP in HK2 cells to identify miR-17/-20a targets […]
- GSE254782 miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [RNA-seq] January 30, 2025Contributors : David L Turner ; Markus Bitzer ; Huanqing Zhang ; Deborah WalterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we evaluated genetic mouse models of inducible renal epithelia-specific miR-17~92 loss-of-function and gain-of-function using unilateral ureteral obstruction. We utilized PAR-CLIP […]
- GSE287414 Wild-Type vs ORAI 2/3 DKO vs ORAI 1/2/3 TKO_Pathogenic Th17 cells_ 48h January 30, 2025Contributors : Beibei Wu ; Spyridon Hasiakos ; Shawn Cokus ; Matteo Pellegrini ; Sonal Srikanth ; Yousang GwackSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTransicriptome comparison between murine WT, ORAI 2/3 DKO, and ORAI TKO pTH17cells at 48 hours following differentiation
- GSE285733 TNFAIP2 promotes NF-κB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKKβ from ubiquitin proteasome degradation January 30, 2025Contributors : Teng Xu ; Yaning Wang ; Zechen Zhao ; Jinsong Wang ; Zhenyuan Zhao ; Yuemei Yang ; Xiaomeng Song ; Qingguo LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor dissemination is a life-threatening event which confers to most cancer-related deaths with limited effective therapeutic option. TNFα-induced […]
- GSE287811 Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration [scRNA-seq] January 30, 2025Contributors : Megan Martik ; Marianne Bronner ; Rekha Dhillon-Richardson ; Alexandra Haugan ; Luke Lyons ; Joseph McKennaSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioDuring vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that migrate to the […]
- GSE287658 Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion January 30, 2025Contributors : Pablo A Alvarez ; Angelica Medina ; Hengli Tang ; Melody LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSeveral alphaviruses bypass the blood-brain barrier (BBB), causing debilitating or fatal encephalitis. Sindbis virus (SINV) has been extensively studied in vivo to understand alphavirus neuropathogen […]
- GSE287813 Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration [bulk ATAC-seq] January 30, 2025Contributors : Megan Martik ; Marianne Bronner ; Rekha Dhillon-Richardson ; Alexandra Haugan ; Luke Lyons ; Joseph McKennaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Danio rerioDuring vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that m […]
- GSE287815 Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration [bulk RNA-seq] January 30, 2025Contributors : Megan Martik ; Marianne Bronner ; Rekha Dhillon-Richardson ; Alexandra Haugan ; Luke Lyons ; McKenna JosephSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioDuring vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that migrate to the […]
- GSE287886 Unraveling Morphogenesis, Starvation, and Light Responses in a Mushroom-Forming Fungus, Coprinopsis cinerea, Using Long Read Sequencing and Extensive Expression Profiling January 30, 2025Contributors : Botond Hegedüs ; Neha Sahu ; Balázs Bálint ; Sajeet Haridas ; Viktória Bense ; Zsolt Merényi ; Máté Virágh ; Hongli Wu ; Xiao-Bin Liu ; Robert Riley ; Anna Lipzen ; Maxim Koriabine ; Emily Savage ; Jie Guo ; Kerrie Barry ; Vivian Ng ; Péter Urbán ; Attila Gyenesei ; Michael Freitag ; Igor V Grigoriev ; László G NagySeries Type : Expression pro […]
- GSE256334 Pre-symptomatic qPCR blood test based on Parkinson’s disease-specific angiogenin-derived transfer RNA fragments January 30, 2025Contributors : Nimrod Madrer ; Shani Vaknine ; Alon Simchovitz ; Estelle R Bennett ; Hermona SoreqSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensRapid, simple and reliable blood tests for Parkinson’s disease (PD) may enable pre-symptomatic diagnosis and facilitate disease-changing treatments. Here, we report escala […]