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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE206754 Molecular mechanism of MLF1 in AC16 cell line January 29, 2025Contributors : Jian Lv ; Ningning Guo ; Yu Fang ; Zhenyi Zhao ; Sai Zeng ; Qiuxiao Guo ; Lili Li ; Zhaoyang Chen ; Zhihua WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrevious studies found that MLF1 mRNA levels tended to decline in aging hearts. Functional studies found that knockdown of MLF1 ameliorated the dru […]
- GSE244615 Early transcriptional similarities between two distinct neural lineages during ascidian embryogenesis January 29, 2025Contributors : Richard R Copley ; Julia Buttin ; Marie-Jeanne Arguel ; Géraldine Williaume ; Kevin Lebrigand ; Pascal Barbry ; Clare Hudson ; Hitoyoshi YasuoSeries Type : Expression profiling by high throughput sequencingOrganism : Ciona robustaIn chordates, the central nervous system arises from precursors that have distinct developmental and transcriptiona […]
- GSE223639 Estrogen-induced NETs promote aseptic inflammation via NKCC1 [human] January 29, 2025Contributors : Yang Sun ; Dijun Chen ; Jiao Qu ; Wen FangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAlthough the formation of neutrophil extracellular traps (NETs) is caused by inflammation-related factors, it remains unclear whether endogen […]
- GSE254717 Extensive folding variability between homologous chromosomes in mammalian cells [GAM] January 29, 2025Contributors : Irastorza-Azcarate Ibai ; Kukalev Alexander ; Kempfer Rieke ; Loof Gesa ; Bing Ren ; Pombo AnaSeries Type : OtherOrganism : Mus musculusGenetic variation and 3D chromatin structure have major roles in gene regulation. Structural differences between genotypically different chromosomes and their effects on gene expression remain ill understood, […]
- GSE250343 U6 snRNP inhibits the premature cleavage and polyadenylation of pre-mRNAs (ChIP-Seq) January 29, 2025Contributors : Qiumin Feng ; Zejin Lin ; Danhui Zhao ; Congting Ye ; Chengguo YaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRNAPII ChIP-seq analysis in U2 and U6 antisense morpholino oligonucleotide (AMO)-treated HeLa cells in comparison to negative control (NC) AMOTo investigate if U2 or U6 AMO treat […]
- GSE266845 Fluo-Cast-Bright: A Deep Learning Pipeline for the Non-Invasive Prediction of Chromatin Structure and Developmental Potential in Live Oocytes January 29, 2025Contributors : Xiangyu Zhang ; Claudia Baumann ; Rabindranath De La FuenteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn mammalian oocytes, large-scale chromatin organization regulates transcription, nuclear architecture, and maintenance of chromosome stability in preparation for meiosis onset. Pre-ovulatory oocytes […]
- GSE261096 Molecular mechanism of EP300 in AC16 cell line January 29, 2025Contributors : Jian Lv ; Qin Chen ; Ningning Guo ; Yu Fang ; Qiuxiao Guo ; Junmei Wang ; Dilinaer Maimaiti ; Jiajie Li ; Xiao Ma ; Weihao Chen ; Li Wang ; Qingqing Yan ; Jingjing Tong ; Zhihua WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFunctional studies found that knockdown of EP300 ameliorated the drug-induce […]
- GSE287979 Systematic inference of super-resolution cell spatial profiles from histology images January 29, 2025Contributors : Peng Zhang ; Chaofei Gao ; Zhiyuan Yuan ; Zhuoyu Zhang ; Shao LiSeries Type : OtherOrganism : Homo sapiensInferring cell spatial profiles from histology images is critical for cancer diagnosis and treatment in clinical settings. In this study, we report a weakly-supervised deep-learning method, HistoCell, to directly predict the super-resoluti […]
- GSE287970 Single-cell RNA sequencing revealed the transcriptional landscape and heterogeneity of macrophages in the intestinal tissues of WT and RUNX3 macrophage conditional knockout mice. January 29, 2025Contributors : yunhuan gao ; yi shiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD11b+ cell populations, especially macrophages, are highly heterogeneous tissue-resident immune cells in mice and humans. The exact subpopulation and its phenotype remain unknown. Here, we analyzed intestinal CD11b+ cell populations from […]
- GSE288040 Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model. January 29, 2025Contributors : Ylauna C Penalva ; Sandra Paschkowsky ; Jingyun Yang ; Sherilyn J Recinto ; Jessica K Cinkornpumin ; Marina Ruelas ; Bin Xiao ; Albert Nitu ; Helen Y Wu ; Hans M Munter ; Bernadeta Michalski ; Margaret Fahnestock ; William A Pastor ; David A Bennett ; Lisa M MunterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus m […]
- GSE287990 Antifungal activity and potential inhibitory mechanism of Huangqin decoction on Trichophyton mentagrophytes January 29, 2025Contributors : Su-Qing Yang ; You-Jin Ge ; Chen-Ying ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Trichophyton mentagrophytesTrichophyton mentagrophytes (T. mentagrophytes) is a prevalent pathogen that causes human and animal dermatophytosis. The clinical treatment of these infections is challenging due to the prolonged trea […]
- GSE288054 Protective effects of two different chaperones demonstrated in a mouse model of sporadic AD January 29, 2025Contributors : Alexander Rezvykh ; Michaedl EvgenevSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPreviously, using various animal models of AD, we demonstrated the protective effect of intranasal administration of chaperones of such different structure as HSP70 and YB-1 at the level of animal’s behavior and functional […]
- GSE288099 Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation January 29, 2025Contributors : Haowen Jiang ; Jiangbin YeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensReduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial r […]
- GSE288122 Recruitment to the nuclear periphery enhances repression of H3K9me2-marked genes and transposons to shape cell fate [CUT&Run II] January 29, 2025Contributors : Harold Marin ; Eric Simental ; Charlie Allen ; Eric Martin ; Barbara Panning ; Bassem Al-Sady ; Abigail BuchwalterSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHeterochromatic loci marked by histone H3 lysine 9 dimethylation (H3K9me2) are enriched at the nuclear periphery in metazoans, but […]
- GSE270417 RNA N6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-γ signaling in gastric cancer [RNA-Seq] January 29, 2025Contributors : Dongjun Jang ; Chanwoong Hwa ; Joon-Yong An ; Sung-Yup ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGastric cancer (GC) is a prominent public health issue, especially in East Asia, and holds the fourth rank in terms of cancer mortality. While immunotherapy holds potential as a treatment avenue for G […]