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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE287468 The transcriptomic changes of patient's derived colorectal cancer organoids induced by drug treatment. January 27, 2025Contributors : June Sung Bae ; Ga Young Ahn ; Hyemin Mun ; Daum Jo ; Eun Jeong ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCBL0137 and Pracinostat effectively induce cell death in KRAS mutant PDCOs but do not significantly regulate KRAS downstream signaling. Treatment with CBL0137 slightly reduced AKT phosphoryla […]
- GSE165589 Human pluripotent stem cell (hPSC)-derived progenies (RNA-Seq) January 27, 2025Contributors : Emiliano Bolesani ; Robert Zweigerdt ; Lavanya M Iyer ; Laura C ZelarayanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe in vitro culture of human cardiac progenitor cells remains a major challenge in biomedicine. The molecular identity of hPSC-derived cardiac progenies and mechanisms controlling thei […]
- GSE287862 Secreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [bulkRNA-Seq] January 27, 2025Contributors : Olga I Kahn ; Casper C HoogenraadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurofilament light chain (NfL) is a neuron-specific cytoskeletal protein that provides structural support for axons and is released into the extracellular space following neuronal injury. While NfL has been extensively studi […]
- GSE230364 Gene expression profile at single cell level of kidney cells of papillary renal cell carcinoma from mice at different stages January 27, 2025Contributors : Jiyuan Liu ; Xiangmin Lv ; Cheng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe role of the Hippo/YAP signaling pathway in renal cell carcinoma remains unclear. Large-scale cancer genetic/genomic studies demonstrated that papillary renal cell carcinoma (PRCC) is featured with a frequent shallow d […]
- GSE165591 Human pluripotent stem cell (hPSC)-derived progenies January 27, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE254368 Acute Resistance Exercise Modifies Extracellular Vesicle miRNAs Targeting Anabolic Gene Pathways: A Prospective Cohort Study January 27, 2025Contributors : William Conkright ; Chris Kargl ; Monica Hubal ; Dakota Tiede ; Meaghan Beckner ; Adam Sterczala ; Kellen Krajewski ; Brian Martin ; Shawn Flanagan ; Julie Greeves ; Thomas O'Leary ; Sophie Wardle ; Amrita Sahu ; Fabrisia Ambrosio ; Brad NindlSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBACKGROUND […]
- GSE253909 The PHR2-DGP1 Signaling Integrates Carbon and Nitrogen Assimilatory Metabolisms under Phosphorus Deficiency Stress in Rice Plants [RNA-seq] January 27, 2025Contributors : Zhan Xu ; Mengmeng Hou ; Jemaa Essemine ; Peng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaCarbon (C), nitrogen (N) and phosphorus (Pi) are crucial macronutrients for plants. While substantial knowledge exists on C/N balance signaling physiological and molecular perspectives, the core regulatory m […]
- GSE287753 Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis. January 27, 2025Contributors : Samuel H Becker ; Christine E Ronayne ; Tyler D Bold ; Marc K JenkinsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlthough lung myeloid cells provide an intracellular niche for Mycobacterium tuberculosis (Mtb), CD4+ T cells limit Mtb growth in these cells to protect the host. Here, we show that monocyt […]
- GSE287750 GemC1 is a critical switch for neural stem cell generation in the postnatal brain January 27, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe subventricular zone (SVZ) is one of two main niches where neurogenesis persists during adulthood, as it retains neural stem cells (NSCs) with self-renewal capacity and multi-lineage potency. Another critical cellular component of the niche is the populati […]
- GSE287818 Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex January 27, 2025Contributors : Jennifer N Burns ; Aaron K Jenkins ; RuoFei Yin ; Wei Zong ; Lauren M DePoy ; Kaitlyn A Petersen ; Mariya Kaminsky ; Chelsea A Vadnie ; Madeline R Scott ; George C Tseng ; Yanhua Huang ; Colleen A McClungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile studies have shown that there are rhythms in gen […]
- GSE287769 Secreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [scRNA-Seq] January 27, 2025Contributors : Olga I Kahn ; Casper C HoogenraadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurofilament light chain (NfL) is a neuron-specific cytoskeletal protein that provides structural support for axons and is released into the extracellular space following neuronal injury. While NfL has been extensively studi […]
- GSE287827 Analysis of SFTS pathogenesis based on single-cell RNA sequencing of monocytes January 27, 2025Contributors : Yin Zhang ; Yuanhong XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSevere fever with thrombocytopenia syndrome (SFTS) is a newly identified tick-borne viral disease with a high mortality rate. Monocytes are known to play an important role in the pathogenesis of SFTS, but the distinct subpopulations of […]
- GSE287849 Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function January 27, 2025Contributors : Nisha D Kamath ; Kenneth A MatreyekSeries Type : OtherOrganism : synthetic constructCalcium signaling is a fundamental molecular means of cellular regulation. Store operated calcium entry (SOCE) is a major intracellular signaling module, wherein calcium release from the endoplasmic reticulum triggers transmembrane STIM1 proteins to conformatio […]
- GSE287855 Clonal cell states link gastroesophageal junction tissues, metaplasia, and cancer [RNA-seq] January 27, 2025Contributors : Rodrigo A Gier ; Raúl A Reyes Hueros ; Jiazhen Rong ; Maureen DeMarshall ; Sydney A Bracht ; Tatiana A Karakasheva ; Amanda B Muir ; Gary W Falk ; Nancy R Zhang ; Sydney M ShafferSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBarrett's esophagus is a common type of metaplasia and a precursor of esop […]
- GSE285782 Effect of kinsenoside on bone marrow-derived macrophages during acute pancreatitis January 27, 2025Contributors : Ruiyan Wang ; Jing Jiang ; Pengli Song ; Qi Peng ; Xuerui Jin ; Jianbo Ni ; Guoyong HuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStudies have shown that the small molecular compound kinsenoside (KD) can inhibit the M1 polarization of macrophages and inhibit the expression of proinflammatory genes. Ho […]