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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE234315 The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis [scRNA-Seq] January 16, 2025Contributors : Miguel Marin-Rodero ; Diane MathisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOur knowledge about the meningeal immune system has recently burgeoned, particularly how innate and adaptive effector cells are mobilized in response to brain challenges. However, information on how meningeal immunocytes gua […]
- GSE193930 Transcriptomic analysis of Ganoderma Microsporum GMI-treated A549 NSCLC cell line. January 16, 2025Contributors : Tung-Yi Lin ; Wei-Jyun Hua ; Wei-Lun HwangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate molecular mechanisms underlying anti-tumoral effects of GMI in lung cancer, we performed RNA-sequencing in GMI-treated A549 cells.
- GSE253344 Potential off-targets investigation of a lead antisense oligonucleotides targeting ABCA4 c.768G>T in retinal organoids January 16, 2025Contributors : Dyah W Karjosukarso ; Rob W Collin ; Sander Bervoets ; Lonneke Duijkers ; Femke BukkemsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStargardt disease type 1 (STGD1) is a progressive retinal disorder caused by bi-allelic variants in the ABCA4 gene. More than 2,400 unique ABCA4 variants have been describ […]
- GSE234317 The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis January 16, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE262499 The RNA interactomes of Imp and Syp reveal temporal RNA regulatory network in Drosophila brain development January 16, 2025Contributors : Jeffrey Y Lee ; Niles Huang ; Tamsin J Samuels ; Ilan DavisSeries Type : OtherOrganism : Drosophila melanogasterThe temporal patterning of neural stem cells is a powerful mechanism to generate neural diversity. In Drosophila, the progression of post-embryonic neurogenesis is driven by RNA-binding proteins Imp (IGF2BP) and Syp (SYNCRIP), howeve […]
- GSE254560 Innate Immune Training of Osteoclastogenesis promotes Inflammatory Bone Loss January 16, 2025Contributors : Nora Haacke ; Hui Wang ; Shu Yan ; Marko Barovic ; Lydia Kalafati ; George Hajishengallis ; Triantafyllos ChavakisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusscRNAseq of myeloid cells from arthritic hind paws upon induction of trained immunity or control treatment
- GSE286904 Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposure January 16, 2025Contributors : Yungyi Hsiao ; Marcos Fonseca ; Andrea M GomezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this project was to assess the cell-type specific transcriptomic changes induced by psychedelics in a rodent model. We used the RiboTag technique to isolate RNA from genetically-defined neuronal subty […]
- GSE272066 Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion January 16, 2025Contributors : Satomi Hirose ; Tatsuya Osaki ; Kamm RogerSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensMetastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasation remain unclear. Molecular targete […]
- GSE286916 Histone deacetylase-1 is required for epigenomic stability in Neurospora crassa [ChIP-seq] January 16, 2025Contributors : Aileen R. Ferraro ; Farh Kaddar ; Clayton Hull-Crew ; Ashley W. Scadden ; Andrew D. Klocko ; Zachary A. Lewis ; Felicia Ebot-OjongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Neurospora crassaPolycomb group (PcG) proteins assemble into chromatin modifying complexes that regulate stem cell identity an […]
- GSE286914 Histone deacetylase-1 is required for epigenomic stability in Neurospora crassa [CUTnRUN] January 16, 2025Contributors : Aileen R. Ferraro ; Farh Kaddar ; Clayton Hull-Crew ; Ashley W. Scadden ; Andrew D. Klocko ; Zachary A. Lewis ; Felicia Ebot-OjongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Neurospora crassaPolycomb group (PcG) proteins assemble into chromatin modifying complexes that regulate stem cell identity an […]
- GSE286972 Effect of GPX4 knockdown on gene expression profile of EBV positive gastric cancer cell line AGS-EBV. January 16, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensReactive oxygen species (ROS) mediated oxidative stress plays an increasingly extensive role in tumorigenesis. Oxidative stress is also an important mechanism for host cells to resist infection by pathogenic microorganisms. Viruses have a similar defense mechanism. Studies […]
- GSE287081 Modulation of predicted key driver genes of an atherosclerosis-associated gene regulatory network in human endothelial cells January 16, 2025Contributors : Prosanta Singha ; Katyayani Sukhavasi ; Tiit Örd ; Minna U Kaikkonen ; Johan L BjörkegrenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCarotid stenosis is a major cause of ischemic strokes both in males and females, but the clinical manifestation and carotid plaque histology differ. Single-cell RNA-Seq […]
- GSE287102 Profiling of RNAs associated with LINE-1 ORF1p in pancreatic ductal adenocarcinoma January 16, 2025Contributors : Eunae You ; Bidish K Patel ; Alexandra S Rojas ; Siyu Sun ; Natalie I Ho ; Ildiko E Phillips ; Michael J Raabe ; Yuhui Song ; Katherine H Xu ; Joshua R Kocher ; Peter M Richiery ; Phoebe Shin ; Martin S Taylor ; Linda T Nieman ; Benjamin D Greenbaum ; David T TingSeries Type : OtherOrganism : Homo sapiensRepeat element viral mimicry is a commo […]
- GSE287105 LINE-1 ORF1p immune evasion mechanisms in pancreatic ductal adenocarcinoma January 16, 2025Contributors : Eunae You ; Bidish K Patel ; Alexandra S Rojas ; Siyu Sun ; Natalie I Ho ; Ildiko E Phillips ; Michael J Raabe ; Yuhui Song ; Katherine H Xu ; Joshua R Kocher ; Peter M Richiery ; Phoebe Shin ; Martin S Taylor ; Linda T Nieman ; Benjamin D Greenbaum ; David T TingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo s […]
- GSE286570 RNA sequencing(RNA-Seq)in liver tissues from different exercise interventions in NAFLD mice January 16, 2025Contributors : Chaorui Hu ; Chuanfei Zeng ; Huan Li ; Mingliang Wei ; Shiqian Liu ; Lianyun Li ; Yong Xiao ; Du Cheng ; Min Wu ; Mingkai ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing(RNA-Seq)in liver tissues from different exercise interventions in NAFLD mice