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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275982 Clonally expanded targetable natural killer-like T cells seed the aged spinal cord to disrupt wound healing [scGEX and TCR] January 12, 2025Contributors : Guiping Kong ; Luming Zhou ; Simone Di GiovanniSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusCD8+ T cells were found accumulated in the spinal cord preceding (aged) and following spinal cord injury. We used single cell TCR sequencing to analyze the clonality of T cells in the spinal cord and dis […]
- GSE193550 Mechanism study of VEGF-B maintaining genomic stability in HUVECs using mRNA sequencing January 12, 2025Contributors : Yi Liu ; Jianing Zhang ; Xuri LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study is to dig out DNA damage pathways mediated by VEGF-B. Using RNA-seq differential expression analysis, we observed genes involved in genomic stability maintainence were upregulated in VEGF-B treated HUVEC […]
- GSE286406 Spatiotemporal Transcriptomics of Hyacinthus orientalis L. cultivars January 12, 2025Contributors : Kwan-Ho Wong ; Hoi-Yan Wu ; Wood-Yee C Shum ; Ho-Lam J Hui ; Pang-Chui Shaw ; Tai-Wai D LauSeries Type : Expression profiling by high throughput sequencingOrganism : Hyacinthus orientalisThis study aims to provide referrable transcriptomic data for the exploration of floral pigment biosynthesis in hyacinth cultivars. This dataset consists of 1 […]
- GSE206498 Bulk mRNA sequencing of adult opossum tissues January 12, 2025Contributors : James Turner ; Bryony Leeke ; Jasmin Zohren ; John VandebergSeries Type : Expression profiling by high throughput sequencingOrganism : Monodelphis domesticaDecades of work in placental (eutherian) species have constructed a paradigm of mammalian development, wherein the genome-wide erasure of parental DNA methylation is required for embryogene […]
- GSE206350 Whole genome bisulfite sequencing of opossum embryos and gametes January 12, 2025Contributors : James Turner ; Bryony Leeke ; Jasmin Zohren ; John VandebergSeries Type : Methylation profiling by high throughput sequencingOrganism : Monodelphis domesticaDecades of work in placental (eutherian) species have constructed a paradigm of mammalian development, wherein the genome-wide erasure of parental DNA methylation is required for embryogen […]
- GSE253482 Cancer-associated fibroblast-specific expression of the matricellular protein CCN1 coordinates neovascularization and stroma deposition in melanoma metastasis January 12, 2025Contributors : James Hutchenreuther ; John Nguyen ; Katherine Quesnel ; Krista M Vincent ; Louis Petitjean ; Sophia Bourgeois ; Mark Boyd ; George Bou-Gharios ; Lynne-Marie Postovit ; Andrew LeaskSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMelanoma is the leading cause of skin cancer-related death. As prognosis of m […]
- GSE234954 Transcriptome analysis of cruabcabc (a triple cruabcciferin (cruabc) mutant of cruabcA, cruabcB, and cruabcC) during seed maturation January 12, 2025Contributor : Ruthie AngeloviciSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaAn in-depth analysis of the cruabc triple mutant showed the importance of translational machinery and response to oxidative stress in proteome rebalancing during the early onset of maturation.
- GSE286107 Loss of the Aryl Hydrocarbon Receptor (AhR) Promotes Cancer Cells Resistance to BRAFV600E Targeted Therapies. [CRISPR] January 12, 2025Contributor : Youssef ErramiSeries Type : OtherOrganism : Homo sapiensPredicting a patient’s response to chemotherapies and identifying additional molecular targets to improve treatment efficacy are major objectives in cancer research. BRAFV600E inhibitors targeting the MAP kinase pathway showed promising initial clinical results in thyroid cancers (TCs) for […]
- GSE286026 Microbial-derived Hyodeoxycholic Acid Ameliorates Painful Diabetic Neuropathy by Modulating Dorsal Root Ganglion TLR4-Mediated Neuroinflammation Signaling Pathway January 12, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusTo explore the mechanism underlying the PDN, we performed transcriptome analysis via RNA-seq on dorsal root ganglion from control and PDN rats.
- GSE286140 Distinct RNA-RNA spatial interaction sub-networks of tran-scription factors in human hepatoma cells January 12, 2025Series Type : OtherOrganism : Homo sapiensWe applied the latest RIC-seq technology to study the RNA-RNA interactions in human liver HepG2 cells. Integrating ChIP-seq data with the RIC-seq data, we clas-sified various transcription factors (TFs) into three distinct clusters based on the spatial interaction levels of the uaRNA (RNA transcribed in promoter regi […]
- GSE286108 Loss of the Aryl Hydrocarbon Receptor (AhR) Promotes Cancer Cells Resistance to BRAFV600E Targeted Therapies. [RNA-Seq] January 12, 2025Contributor : Youssef ErramiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPredicting a patient’s response to chemotherapies and identifying additional molecular targets to improve treatment efficacy are major objectives in cancer research. BRAFV600E inhibitors targeting the MAP kinase pathway showed promising initial […]
- GSE286204 Genome-Wide Profiling of Circulating MicroRNAs in Adolescent Idiopathic Scoliosis January 12, 2025Contributors : Nasrin Khatami ; Iurie Caraus ; Mahamuda Rahaman ; Evguenia Nepotchatykh ; Mohamed Elbakry ; Wesam Elremaly ; Anita Franco ; Marie Beauséjour ; Anne-Marie Laberge ; Stefan Parent ; Hubert Labelle ; Carl-Éric Aubin ; Jean Lachaine ; Alain MoreauSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensAdolescent Idiopathic Scoliosis […]
- GSE286223 Genomic, tanscriptomic and metabolimic analyses of Amorphophallus albus provides insights into the evolution and resistance to southern blight pathogen January 12, 2025Contributors : longfei duan ; baofu qin ; chuan shenSeries Type : Expression profiling by high throughput sequencingOrganism : Amorphophallus albusGenomic, tanscriptomic and metabolimic analyses of Amorphophallus albus provides insights into the evolution and resistance to southern blight pathogen
- GSE286372 Pyrimidine synthase CAD deamidates and inactivates p53 January 12, 2025Contributors : Qi Yue ; Tan Zizheng ; Chen Hanyu ; Xiao Ziqi ; Zhang Liang ; Wu Boxuan ; Liu Chennan ; Gao Yunqian ; Yang Xueyan ; Wu Lingqian ; Lu Lei ; Wang HongyanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensp53, a critical tumor suppressor, regulates the cell cycle in response to DNA damage and metabolic changes. […]
- GSE275570 Clonally expanded targetable natural killer-like T cells seed the aged spinal cord to disrupt wound healing January 12, 2025Contributors : Guiping Kong ; Luming Zhou ; Simone Di GiovanniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8+ T cells that were found accumulated in the spinal cord preceding (aged) and following a spinal cord injury disrupt wound healing. We isolated spinal cord cells of the aged mice who were treated with IgG or […]