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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE286224 Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [microC] January 10, 2025Contributors : Ke Zhao ; Yao Zhou ; Mulin JunLiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe majority of genetic loci linked to polygenic complex traits are found in non-coding regions of the human genome. These loci often exhibit complex gene regulatory relationships and linkage disequilibrium (LD) […]
- GSE254705 CXCL12 produced from Foxl1high mesenchymal cells modulates epithelial cell metabolism and prevents intestinal neoplasia (RNA-Seq) January 10, 2025Contributors : Mayu Yagita-Sakamaki ; Tkayoshi ItoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSeveral mesenchymal cell populations are involved in the maintenance and differentiation of intestinal stem cells (ISCs) by secreting Wnts, R-spondins, and bone morphogenetic proteins. However, the influences of signaling m […]
- GSE213158 Multipotent neural stem cells originating from neuroepithelium exist outside of the mouse central nervous system January 10, 2025Contributors : Dong Han ; Daniela Gerovska ; Marcos J Araúzo-Bravo ; Hans R SchölerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIt has been widely accepted that mammalian neural stem cells (NSCs) exist only in the central nervous system. Here, we report that peripheral NSCs (pNSCs) exist outside of the CNS and can be […]
- GSE184756 Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa and EB [m6A in HeLa] January 10, 2025Contributors : Andrea Li Greci ; Giuseppe Quarto ; Martin Bizet ; Jérôme Martin ; Liliana Garcia-Martinez ; Pankaj Kumar ; Emilie Calonne ; Pierre-Olivier Esteve ; Elizabeth Caine ; Gaurav Dube ; Bouchra Hassabi ; Irina Primac ; Audrey Penning ; Jie Lan ; Danette Daniels ; Sriharsa Pradhan ; Rachel Deplus ; Lluis Morey ; Jana Jeschke ; François FuksSeries Ty […]
- GSE243021 The impact of Srebf2 deletion on the transcriptional phenotype of visceral adipose tissue (VAT) regulatory T (Treg) cells January 10, 2025Contributors : Christopher D Scharer ; Chaoran LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRegulatory T (Treg) cells are highly enriched in the visceral adipose tissue (VAT) to maintain metabolic homeostasis, but they are lost during obesity. VAT Treg cells exhibit enhanced Srebf2-dependent cholesterol metabolism […]
- GSE222050 ITK-SYK induced peripheral T-cell lymphomas induce granulocyte activation January 10, 2025Contributors : Geoffroy Andrieux ; Melanie Boerries ; Amelie Jäger ; Christine DierksSeries Type : Expression profiling by arrayOrganism : Mus musculusITK-SYK or control vector were overexpressed in Balb/c mice and ITK-SYK mice developed peripheral T-cell lymphomas within 5 weeks. CD4+ T-cells and granulocytes were harvested from the spleens of control and I […]
- GSE281049 Molecular control of PDPNhi macrophage subset induction by ADAP as a host defense in sepsis II January 10, 2025Contributors : Pengchao Zhang ; Xinning Wang ; Xiaodong Yang ; Hebin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe macrophage response to infected microbes is crucial for the development of life-threatening sepsis. However, the mechanisms underlying pathophysiological regulation of macrophage subsets during sep […]
- GSE253003 Transcriptional changes upon overexpression of seven candidate miRNAs in human saphenous vein smooth muscle cells. [HSVSMC] January 10, 2025Contributors : Andrew H Baker ; Jean Iyinikkel ; Julie RodorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProliferation of vascular smooth muscle cells (vSMCs) following injury is a crucial factor contributing to pathological vascular remodelling. MicroRNAs (miRNAs) are powerful gene regulators and attractive therapeu […]
- GSE285879 YAP1 Activation Rescues Nagashima-type Palmoplantar Keratosis Pathological Features in Skin Organoid Disease Models January 10, 2025Contributors : Jun Liu ; Wen Zheng ; Yingying Luo ; Tao Yang ; Huiting Liu ; Qiuping Zhang ; Qiuyu Chen ; Bin YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensYAP1 activation rescues NPPK pathological features Abstract Nagashima-type palmoplantar keratosis (NPPK), a recessive genetic skin disorder, is characterized b […]
- GSE281052 Molecular control of PDPNhi macrophage subset induction by ADAP as a host defense in sepsis III January 10, 2025Contributors : Pengchao Zhang ; Xinning Wang ; Xiaodong Yang ; Hebin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe macrophage response to infected microbes is crucial for the development of life-threatening sepsis. However, the mechanisms underlying pathophysiological regulation of macrophage subsets during sep […]
- GSE285935 Eggerthella lenta Down Regulated Flavone and Flaconol Biosynthesis Promoted Kawasaki Disease January 10, 2025Contributors : Yao-Tsung Yeh ; Kuang-Den Chen ; Cheng-Hsieh Huang ; Ho-Chang KuoSeries Type : OtherOrganism : human feces metagenomeKawasaki Disease (KD) is a multisystemic vasculitis of unknown etiology in children. The incidence of KD varies by geographic area and correlates with differences in gut microbiota patterns, with the highest incidence in Asian. […]
- GSE286205 Endogenous fine-mapping of functional regulatory elements in complex genetic loci in HAP1 [scMulti] January 10, 2025Contributors : Ke Zhao ; Yao Zhou ; Mulin JunLiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe majority of genetic loci linked to polygenic complex traits are found in non-coding regions of the human genome. These loci often exhibit complex gene regu […]
- GSE286220 Transcriptome response of the white-rot fungus Trametes versicolor to hybrid poplar exhibiting unique lignin chemistry January 10, 2025Contributors : Anbarah R Alzabaidi ; Noor Alabbasi ; Richard Meilan ; Scott J Meiners ; Thomas CanamSeries Type : Expression profiling by high throughput sequencingOrganism : Trametes versicolorBackground: Production of biofuels and bioproducts from lignocellulosic material is limited due to the complexity of the cell wall structure. This necessitates the us […]
- GSE253088 The cationic liposome of trehalose dimycolate (TDM) inducees antitumor immunity in bladder. January 10, 2025Contributors : Kozaburo Tanuma ; Jun Miyazaki ; Masanobu Shiga ; Keisuke Sano ; Yoshiyuki NagumoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBCG therapy is the most effective immunotherapy for bladder cancer, but it sometimes causes serious adverse events because of infection with live BCG bacteria. To develop more e […]
- GSE281047 Molecular control of PDPNhi macrophage subset induction by ADAP as a host defense in sepsis January 10, 2025Contributors : Pengchao Zhang ; Xinning Wang ; Xiaodong Yang ; Hebin LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe macrophage response to infected microbes is crucial for the development of life-threatening sepsis. However, the mechanisms underlying pathophysiological regulation of macrophage subsets during sep […]