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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE266193 Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome [RNA-seq] January 8, 2025Contributors : Courtney W Hanna ; Georgia Lea ; Vicente Perez-GarciaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs) and hundreds of placental-specific imprinted domains. Furthermore, the placental ‘methylome’ has been […]
- GSE264080 Comparative framework and adaptation of ACME HS approach to single cell isolation from fresh-frozen endocrine tissue. January 8, 2025Contributors : Marina Utkina ; Anastasia Shcherbakova ; Ruslan Deviatiiarov ; Valentin TrofimovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCurrent dissociation methods for scRNA-seq studies of solid tissues do not guarantee intact single-cell isolation from fresh frozen samples, especially for sensitive and heteroge […]
- GSE285861 Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer January 8, 2025Contributors : Agniewszka K Witkiewicz ; Jianxin Wang ; Emily Schultz ; Thomas N O'Connor ; Tracey O'Connor ; Ellis Levine ; Erik S KnudsenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCDK4/6 inhibitors in combination with endocrine therapy are widely used to treat HR+/HER2- metastatic breast cancer leading […]
- GSE266194 Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome [ChIP-seq] January 8, 2025Contributors : Courtney W Hanna ; Georgia Lea ; Vicente Perez-GarciaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs) and hundreds of placental-specific imprinted domains. Furthermore, the placental ‘methyl […]
- GSE252715 CPL mitigates myeloproliferative neoplasms through dual targeting of cell senescence and NF-κB signaling January 8, 2025Contributors : Mingjie Liu ; Baobing ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the therapeutic effect of CPL on myeloproliferative neoplasms. We then performed gene expression profiling using data obtained by RNA-seq in SET-2 cells treated with or without CPL.
- GSE198191 Nuclear Talin-1 Provides a Bridge Between Cell Adhesion and Gene Expression January 8, 2025Contributors : Alejandro J Da Silva ; Hendrik S Hästbacka ; Mikael C Puustinen ; Jenny C Pessa ; Jens C Luoto ; Erika Sundström ; Benjamin T Goult ; Guillaume Jacquemet ; Eva Henriksson ; Lea SistonenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTalin-1 (TLN1) is best known to activate integrin receptors and transmit […]
- GSE280530 Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR January 8, 2025Contributors : Kory Melton ; Benjamin Gowen ; Spencer Wei ; Weng In Leong ; Prachi Khekare ; Shannon McCawley ; Pierre Boivin ; Vihasi Jani ; Aaron J. Cantor ; Jean Chan ; Mary Haak-Frendscho ; Mary Janatpour ; Akshay TambeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTherapeutic targeting of the adenosine deaminase A […]
- GSE253273 RNA-sequencing analysis gene expression changes of astrocytes treated with TGF- β1 in response to oxygen-glucose deprivation/reperfusion January 8, 2025Contributor : Qiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusAstrocytes are abundant glial cells in the central nervous system (CNS) that play important roles in cerebral ischemia-reperfusion injury. Following brain ischemia, astrocytes can trigger endogenous neuroprotective mechanisms such as neurogene […]
- GSE283825 Expression data from RD cells January 8, 2025Contributor : Monika EhnmanSeries Type : Expression profiling by arrayOrganism : Homo sapiensMesenchymal stromal cells belong to a diverse collection of cells in different states that are poorly characterized in soft-tissue sarcomas.We used microarrays to explore differentially expressed genes in pediatric rhabdomyosarcoma cells (RD) after exposure to non-ma […]
- GSE281299 Newly found rat CD103- dendritic cells are the highly immunogenic conventional DC2 subpopulation, corresponding to the known DC subsets in mice and humans. January 8, 2025Contributors : Yasushi Sawanobori ; Tadayuki Ogawa ; Hisashi Ueta ; Yusuke Kitazawa ; Nobuko TokudaSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusDendritic cells (DCs), the primary antigen-presenting cells, have traditionally been identified by CD103 molecules in rats, whereas mouse and human DCs are identified by CD11c molecules. How […]
- GSE285815 Effect of HERV-R env Knockout on Tumorigenic Characteristics of Colorectal Cancer Cells January 8, 2025Contributors : Min-Hye Kim ; Eun-Ji Ko ; HyoJin An ; Heui-Soo Kim ; Sun-Hee Leem ; Hee-Jae ChaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the cancer properties of HERV-R knockout in the colon cancer cell line DLD1, we knocked out HERV-R from Crispr-cas9 in DLD1. We performed RNA-seq to profile gene ex […]
- GSE285818 The role of USF3 in γδ T cells January 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExplore the role of USF3 in γδ T cells.
- GSE285847 Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia January 8, 2025Contributors : Jiyun Zhou ; Chongyuan Luo ; Hanqing Liu ; Matthew G Heffel ; Richard E Straub ; Joel E Kleinman ; Thomas M Hyde ; Joseph R Ecker ; Daniel R Weinberger ; Shizhong HanSeries Type : OtherOrganism : Homo sapiensDNA methylation (DNAm) is a crucial epigenetic mark and plays a key role in gene regulation, mammalian development, and various human dis […]
- GSE263784 Comparative framework and adaptation of ACME HS approach to single cell isolation from fresh-frozen endocrine tissue [dataset 2] January 8, 2025Contributors : Marina Utkina ; Anastasia Shcherbakova ; Ruslan Deviatiiarov ; Valentin TrofimovSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCurrent dissociation methods for scRNA-seq studies of solid tissues do not guarantee intact single-cell isolation from fresh frozen samples, especially for sensitive and heteroge […]
- GSE273828 UFMylation maintains YAP stability to promote vascular endothelial cell senescence January 8, 2025Contributors : Yanan Liu ; Min Zuo ; Aiwei Wu ; Siting Wang ; Yongping Bai ; Junzhi Zhou ; Hu WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndothelial cell senescence is an accomplice for vascular aging, which leads to cardiovascular diseases (CVD). Evidences showed that Hippo- Yes-associated protein (YAP) signal […]