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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE245553 Induction of differentiation from hiPSCs into Leydig-like cells (scRNA-Seq) January 7, 2025Contributors : Katsuya Sato ; Michiyo Koyanagi-Aoi ; Takashi AoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe generated Leydig-like cells by the forced expression of NR5A1 in hiPSCs and by switching from 3D culture to adherent culture.
- GSE251904 BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation January 7, 2025Contributors : Stefania Tavano ; David B Brueckner ; Saren Tasciyan ; Xin Tong ; Roland Kardos ; Alexandra Schauer ; Robert Hauschild ; Carl-Philipp HeisenbergSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioCell migration is a fundamental process during embryonic development. Most studies on cell migration in vivo have f […]
- GSE250395 Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [Visium] January 7, 2025Contributors : Jason Guo ; Michelle Griffin ; Michael Januszyk ; Derrick Wan ; Tushar Desai ; Michael LongakerSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusFibrosis, the replacement of healthy tissue with collagen-rich matrix, can occur following injury in almost every organ. Mouse lungs follow stereotyped seq […]
- GSE271258 ac4C transcriptomes of Zebrafish and Worm January 7, 2025Contributors : Zekai Wu ; An Zhu ; Kunqi ChenSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Caenorhabditis elegans ; Danio rerioac4C modification appears in mutilple model organisms including Zebrafish and Worm
- GSE268090 Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons January 7, 2025Contributors : Anna M Kollstrøm ; Nicholas Christiansen ; Axel Sandvig ; Ioanna SandvigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAmyotrophic lateral sclerosis (ALS) is characterized by dysfunction and loss of upper and lower motor neurons. Several studies have identified structural and functional alterations in th […]
- GSE272796 Glucocorticoid Receptor Suppresses GATA6-Mediated RNA Polymerase II Pause Release to Modulate Classical Subtype Identity in Pancreatic Cancer January 7, 2025Contributors : Thomas L Ekstrom ; Steven A JohnsenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a five-year survival rate of 12%. It has two major molecular subtypes: classical and basal, regulated by the master transcription factors (MTFs) GATA6 a […]
- GSE271734 Glucocorticoid Receptor Suppresses GATA6-Mediated RNA Polymerase II Pause Release to Modulate Classical Subtype Identity in Pancreatic Cancer January 7, 2025Contributors : Thomas L Ekstrom ; Steven A JohnsenSeries Type : OtherOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a five-year survival rate of 12%. It has two major molecular subtypes: classical and basal, regulated by the master transcription factors (MTFs) GATA6 and ΔNp63, respectively. This study aims to un […]
- GSE285771 Orai1 in pancreatic ductal cells mediates pancreas-intestinal crosstalk in experimental acute pancreatitis via the secretion of antimicrobial peptide REG3B in pancreatic juice January 7, 2025Contributor : Li WenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal epithelial cells (PDECs) play a crucial role in the development of acute pancreatitis (AP). We and others have previously shown that Orai1 inhibitor confers protection against AP severity. In this study, we aim to investigate the effec […]
- GSE285740 PRMT1-methylated MSX1 phase separates to control palate development January 7, 2025Contributors : Junqing Ma ; Li Meng ; Yucheng Jiang ; Liming Chen ; Jiawen YouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLittle is known about the regulation and function of liquid‒liquid phase separation (LLPS) in craniofacial developmental disorders, where Msh homeobox 1 (MSX1) and protein arginine methyltransfer […]
- GSE285883 The Colorado potato beetle gene expression atlas January 7, 2025Contributors : Léonore Wilhelm ; Yangzi Wang ; Shuqing XuSeries Type : Expression profiling by high throughput sequencingOrganism : Leptinotarsa decemlineataThe Colorado potato beetle (CPB) is a major pest of potato crops that has evolved resistance to more than 50 pesticides. For decades, CPB has been a model species for research on insecticide resistance, […]
- GSE285788 The secreted proteases Aur, ScpA, SspA and SspB suppress the virulence of Staphylococcus aureus USA300 by shaping the extracellular proteome January 7, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe secreted proteases Aur, ScpA, SspA and SspB suppress the virulence of Staphylococcus aureus USA300 by shaping the extracellular proteome
- GSE285893 Comparative evaluation of the biological characteristics of a novel retinoid X receptor agonist and bexarotene II January 7, 2025Contributors : Koji Tomita ; Ken-ichi Nakashima ; Eiji Yamaguchi ; Akichika Itoh ; Kaname Tsutsumiuchi ; Makoto InoueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRetinoid X receptor (RXR) is a crucial and distinctive member of the nuclear receptor superfamily, which is involved in regulating various physiological pro […]
- GSE285956 Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation January 7, 2025Contributors : Ting Zhang ; Shi-min Zheng ; Jian-bin Yin ; Bing-bing WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUlcerative colitis (UC), a form of inflammatory bowel disease, is characterized by a Q7 recurrent and persistent nonspecific inflammatory response. Polydatin (PD), a natural stilbenoid polyphenol with po […]
- GSE285980 AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo. January 7, 2025Contributors : Marina Pavlou ; Marlene Probst ; Lew Kaplan ; Elizaveta Filippova ; Aric R Prieve ; Fred Rieke ; Thomas A RehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe lack of regeneration in the human central nervous system (CNS) has major health implications. To address this, we previously used transgenic mous […]
- GSE285981 A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth January 7, 2025Contributors : Iratxe Zuazo-Gaztelu ; Ximo Pechuan-Jorge ; Zora Modrusan ; Avi AshkenaziSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndoplasmic-reticulum resident inositol-requiring enzyme 1a (IRE1) supports protein homeostasis via its cytoplasmic kinase-RNase module. Known cancer dependency on IRE1 entails its enzy […]