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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE250220 YAP1 regulates thrombopoiesis by binding to MYH9 in immune thrombocytopenia December 22, 2024Contributors : Shuhong Hu ; Yifei Liu ; Depei Wu ; Yang XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmune thrombocytopenia (ITP) is a complicated bleeding disease characterized by sharp platelet reduction. As a dominating element involved in ITP, megakaryocytes (MKs) are responsible for thrombopoiesis. However, t […]
- GSE243531 Pervasive RNA Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization [Hi-C] December 22, 2024Contributors : Huating Wang ; Qiang Sun ; Qin ZhouSeries Type : OtherOrganism : Homo sapiens ; Mus musculusHi-C in RBFox2 knockdown K562 and RBFox2 knockout C2C12 cells, Hi-C in ActD, RNase, and RNase inhibitor (RIN) treated C2C12 cells.
- GSE173346 Genome-wide reconstruction of the bacterial response to single and multiple stress in Shigella flexneri 2a str. 2457T (S. flexneri RNA-Seq) December 22, 2024Contributors : Khoi N Pham ; Joon Y Park ; Nong K Linh ; Donghyuk KimSeries Type : Expression profiling by high throughput sequencingOrganism : Shigella flexneriThe genome-wide analysis was carried out to find out the genes responsible for single and multiple stress in Shigella flexneri 2a str. 2457T. This result can be offered to explain bacterial responses […]
- GSE284598 Association between Activated Loci of HML-2 Primate-Specific Endogenous Retrovirus and Newly Formed Chromatin Contacts in Human Primordial Germ Cell-like Cells December 22, 2024Contributors : Vargas Bianca Cordazzo ; Shioda ToshihiroSeries Type : OtherOrganism : Homo sapiensThe pluripotent stem cell (PSC)-derived human primordial germ cell-like cells (PGCLCs) are a cell culture-derived surrogate model of embryonic primordial germ cells. Upon differentiation of PSCs to PGCLCs, multiple loci of HML-2, the hominoid-specific human endo […]
- GSE185673 RNA-Seq of lung fibroblasts of Atm defecient and wildtype mice. December 22, 2024Contributors : Majd Haj ; Amit Levon ; Yann Frey ; Ran Elkon ; Judith Campisi ; Yael Ziv ; Yosef ShilohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe applied RNA-Seq on lung fibroblasts derived from Atm defecient as well as wildtype mice to further understand and reveal a novel pathawy involved in the premture senes […]
- GSE173348 Genome-wide reconstruction of the bacterial response to single and multiple stress in Shigella flexneri 2a str. 2457T December 22, 2024Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Escherichia coli ; Shigella flexneriThis SuperSeries is composed of the SubSeries listed below.
- GSE284056 Responses to temperature shocks in Zymoseptoria tritici reveal specific transcriptional reprogramming and novel candidate genes for thermal adaptation December 22, 2024Contributors : Silvia Minana-Posada ; Silvia Minana-Posada ; Cecile LorrainSeries Type : Expression profiling by high throughput sequencingOrganism : Zymoseptoria triticiThe transcriptomic response of Zymoseptoria tritici IPO323 spores under heat and cold shock.
- GSE235472 Inducible nitric oxide synthase is repressed by Nuclear Factor Erythroid 2-Related Factor 2 in KRAS-driven pancreatic cancer cells December 22, 2024Contributors : Nicolò Gualandi ; Ylenia Cortolezzis ; Eros Di Giorgio ; Luigi E XodoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNitric oxide is a pleiotropic free radical produced by three nitric oxide synthases (NOS1-3), of which the inducible NOS2 is involved in carcinogenesis. In this study, RNA-seq […]
- GSE284404 Increased cardiac macrophages in Sorbs2-deficient hearts: revealing a potential role for macrophage in responding to embryonic myocardial abnormalities December 22, 2024Contributors : Beibei Hu ; Min Zhang ; Shanshan XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophages are known to support cardiac development and homeostasis, contributing to tissue remodeling and repair in the adult heart. However, it remains unclear whether embryonic macrophages also respond to abnormaliti […]
- GSE284388 Assessing biosimilarity of Trastuzumab monoclonal antibody therapeutics using RNA sequencing of treated SKBR3 cells December 22, 2024Contributors : Karsten Rinas ; Brendan McConkeySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatents of some therapeutic monoclonal antibodies (mAb) used for cancer treatment are ending soon, allowing for the entry of similar analogs (biosimilars) onto the market. To have a biosimilar approved by health agencies, the […]
- GSE284499 Transdifferentiation of Rat Keratinocyte Progenitors to Corneal Epithelial Cells by Limbal Niche via the STAT3/PI3K/AKT signaling pathway December 22, 2024Contributor : Bei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPURPOSE. To develop a method for enriching keratinocyte progenitor cells (KPCs) and establish a limbal niche (LN)-mediated transdifferentiation protocol to induce KPCs transdifferentiation into corneal epithelial cells. METHODS. Limbal niche cell […]
- GSE284505 Chronic sleep deprivation promotes experimental autoimmune uveitis through STAT1 phosphorylation, ISG15 expression and enhanced pathogenicity of macrophages December 22, 2024Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAutoimmune uveitis (AU) is a severe intraocular inflammatory disease driven by dysregulated T-cell immunity and macrophage activation, leading to retinal tissue damage. Experimental autoimmune uveitis (EAU), an animal model, closely mimics human AU, highlighting the role o […]
- GSE284506 RNA sequencing of wild-type and FBXO32-knockout hepatocellular carcinoma Huh7 cells December 22, 2024Contributors : Feng Li ; Hongqiang Yu ; Yujun Zhang ; Fengtian He ; Leida Zhang ; Chuanming Xie ; Haojun XiongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFBXO32 is upregulated in multiple human cancers, including hepatocellular carcinoma (HCC), pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA), an […]
- GSE243420 Pervasive RNA Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization [ChIP-seq] December 22, 2024Contributors : Huating Wang ; Qiang Sun ; Qin ZhouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRBFox2 ChIP-seq in WT, ActD, RIN, RNase treated C2C12 cells.
- GSE281746 Differential responses to selective CDK2 inhibitor BLU-222 is conditioned by tumor suppressors December 22, 2024Contributors : Adam P Dommer ; Vishnu Kumarasamy ; Jianxin Wang ; Thomas N O'Connor ; Michelle Roti ; Sidney Mahan ; Karen McLean ; Erik S Knudsen ; Agnieszka K WitkiewiczSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe selective CDK2 inhibitor BLU-222 was evaluated for mechanisms of response in the context of o […]