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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275507 The molecular basis for the attenuation of the yellow fever 17D vaccine [wtYFV_RNAseq] May 13, 2025Contributors : Jiayu Zhang ; Aaron Lin ; Alexander PlossSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensYellow fever virus, a prototypical member of the Flaviviridae family, is a small single-stranded, positive sense enveloped RNA virus causing viscerotropic, frequently fatal disease. Serial passaging of the virulent YF […]
- GSE270461 Adipose-derived Stem cll and Stronal Vascular Fraction response to inflammation sc RNA seq May 13, 2025Contributors : Darling Eric ; Parsons Adrienne ; Ahsan NagibSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe therapeutic potential of mesenchymal stem/stromal cells (MSCs) relies on their ability to modulate immune responses in disease and wound contexts. In this study, we present an analytical pipeline using establi […]
- GSE281592 Transcriptome Analysis in Human Breast Milk and Blood in a Randomized Trial after Inactivated or Attenuated Influenza Immunization May 13, 2025Contributors : Elizabeth P Schlaudecker ; Travis L Jensen ; Casey E Gelber ; Phillip J Dexheimer ; Mark C Steinhoff ; David I Bernstein ; Johannes B GollSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscriptomic signatures were identified in human peripheral blood mononuclear cells (PBMCs) and breast milk lymphocyte […]
- GSE279383 Transcriptome profiles of RAW264.7 cells under fibroblast coculture with or without LPS sitimulation and tryptophan metabolites intervention May 13, 2025Contributors : Yihuang Huang ; Luyang Hong ; Shangyu Hong ; Yun CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA sequencing to identify the role of fibroblast in the effects of tryptphan metabolites on LPS-stimulated RAW264.7 cells.
- GSE247961 scRNA-seq analysis of human iPSC derived Hepatocyte organoids (iHOs) [scRNA-seq] May 13, 2025Contributors : Taro Shimizu ; Masato Miyoshi ; Sei KakinumaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver has abundant regenerative capacity, but hepatocytes cannot be cultured long-term in vitro. Activation of FXR signaling induced iHOs with both hepatocyte traits and proliferative potential. To investigate the […]
- GSE204765 Multi-modal skin atlas associates a multicellular immune-stromal community with altered cornification and T cell expansion in atopic dermatitis. May 13, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE296744 Differentially expressed mRNA in biological premature ovarian insufficient (bPOI) May 13, 2025Contributors : Xue Jiao ; Nianyu Li ; Hanbing ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have completed the mRNA expression profiling of human granulosa cells to reveals the differentially expressed mRNAs involved in POI.
- GSE259424 Hypoxia is responsible for the altered response of ovarian cancer cells to the mitomycin C-drug May 13, 2025Contributors : Aleksandra Gawrylak ; Klaudia K Brodaczewska ; Roksana Iwanicka-Nowicka ; Marta Koblowska ; Agnieszka Synowiec ; Lubomir Bodnar ; Cezary Szczylik ; Bogdan Lesyng ; Rafał Stec ; Claudine KiedaSeries Type : Expression profiling by arrayOrganism : Homo sapiensUsing HTA 2.0 microarrays, we demonstrate transcriptome changes in ovarian cancer SKOV3 […]
- GSE296886 Effect of a natural product derivative on gene expression signatures in 5xFAD transgenic mice May 13, 2025Contributor : Jiaxue ChaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate how a natural product analog mitigates AD, cortical transcriptomes from WT and 5xFAD mice were analyzed. Comparing vehicle-treated groups revealed extensive differential expression associated with neuroinflammation in 5xFAD mice. This […]
- GSE296865 Identification of transcription factors dictating blood cell development using a bidirectional transcription network-based computational framework [CAGEseq_MLLAF9-AML 2] May 13, 2025Contributors : Branco Heuts ; Saioa Apalategi ; Bert van der Reijden ; Joost MartensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide transcription factor binding profiles provide valuable insights into hematopoietic development and malignancies. Today, advanced computational methods exploit cis-regulatory inf […]
- GSE296969 Gene expression at single cell level of stromal cells from the distal colon of normal sites of colorectal cancer and inflamed sites of ulcerative colitis. May 13, 2025Contributors : Hazuki Miyazaki Yuki Ito ; Takayuki Ogino Hiroyuki Itoi ; Bo-Li Yuki sekido ; Ryota Mori Terukazu Yoshihara ; Liu Yuchen Daisuke Okuzaki ; Mitsunobu Takeda Tsuyoshi Hata ; Atsushi Hamabe Norikatsu Miyoshi ; Mamoru Uemura Yuichiro Doki ; Hidetoshi Eguchi Kiyoshi Takeda ; Hisako KayamaSeries Type : Expression profiling by high throughput sequenc […]
- GSE296975 Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids [MFI017_Visium] May 13, 2025Contributors : Cole McCutcheon ; Carolyn CoyneSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Sus scrofaIn this study we had two primary aims: 1.) spatially define the transcriptional signatures of porcine maternal-fetal interface and 2.) develop and validate an organoid model which better recapitulated the porcine placenta […]
- GSE297010 Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development. May 13, 2025Contributors : Agata I Kalita ; Eric Marois ; Frank Rühle ; Claudia I Keller ValsecchiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Anopheles gambiaeMalaria-transmitting mosquitoes are extremely sexually dimorphic in their anatomy and behaviour. Sex-specific gene expression in Anopheles gambiae is well-studied in ad […]
- GSE267502 RNA-seq analysis of RNA polymerase I inhibitor in p53 null HCT116 colon adenocarcinoma cells. May 13, 2025Contributors : Wenjun Fan ; Hester Liu ; Marikki LaihoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRibosome biosynthesis is essential for cancer growth and proliferation. This dependency is therapeutically exploitable by blocking the rate-limiting step, RNA polymerase I (Pol I) transcription. Here we investigated the […]
- GSE296703 The novel ZBTB5::JAK2 fusion gene reveals a new mechanism of kinase activation in Ph-like acute lymphoblastic leukemia May 13, 2025Contributors : Qiang Qiu ; Juan Xu ; Tong Chen ; Ting LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPhiladelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a distinct subtype of B-ALL, exhibiting a kinase-activated gene expression profile similar to Philadelphia chromosome-positive (Ph+) ALL, yet […]