Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE301018 Transcriptome of floating aggregate biofilms in Pseudomonas aeruginosa June 27, 2025
  Contributors : Rahan R Nazeer ; Welch MartinSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosaPseudomonas aeruginosa is a critical priority pathogen, whose proclivity to establish chronic infections and to resist antibiotic treatment is intimately linked to its ability to form biofilms at the infection site. Rec […]
• GSE251747 SMCHD1 controls the structure and accessibility of heterochromatin and functions as an organizer of genome compartments (ChIP-Seq) June 27, 2025
  Contributors : Zhijun Huang ; Gerd PfeiferSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensStructural Maintenance of Chromosomes flexible Hinge Domain containing 1 (SMCHD1) is an SMC-like protein that plays an important role in X chromosome inactivation and is mutated in two human diseases, a muscular dystr […]
• GSE235999 Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [RNA-seq] June 27, 2025
  Contributors : Walid Fakhouri ; Lisha Zhu ; Jim ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMost DNA variants associated with common complex diseases fall outside the protein-coding regions of the genome, making them hard to detect and relate to a function. Although many computational tools are available for pr […]
• GSE267232 Single-cell transcriptome profiling reveals blast cell heterogeneity and identifies novel therapeutic target IKZF2 in t(8;21) acute myeloid leukemia (ATAC-seq) June 27, 2025
  Contributors : Jianxiang Wang ; Shaowei Qiu ; Yu LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo clarify the role of AML1-ETO in aberrant hematopoiesis, we generated conditional AML1-ETO knock-in mice. Our research indicated AML1-ETO induction impaired bone marrow hematopoietic reconstitution and res […]
• GSE251751 SMCHD1 controls the structure and accessibility of heterochromatin and functions as an organizer of genome compartments (WGBS) June 27, 2025
  Contributors : Zhijun Huang ; Gerd PfeiferSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensStructural Maintenance of Chromosomes flexible Hinge Domain containing 1 (SMCHD1) is an SMC-like protein that plays an important role in X chromosome inactivation and is mutated in two human diseases, a muscular dystrophy, and a r […]
• GSE270922 Unraveling the immunological roles of murine serum amyloid A3 in aortic immune cell subsets during atherosclerosis progression June 27, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtherosclerosis is a growing concern in developed nations, necessitating the identification of therapeutic targets for advancing personalized medicine. Serum amyloid A3 (Saa3) has been linked to accelerated plaque progression by affecting cholesterol metabolism and modulat […]
• GSE267871 Identifying Multiple Genomic Abnormalities and Predicting Neoantigens from Single Tumor Cells [PRJNA1110293] June 27, 2025
  Contributors : Da Lin ; Xinyu Li ; Xiaochen GaoSeries Type : OtherOrganism : Mus musculusTumors exhibit high heterogeneity due to distinct genomic aberrations in individual cells. Despite this, no methods currently exist to detect these genomic abnormalities at the single-cell level. To address this, we developed Uniform Chromosome Conformation Capture (Uni- […]
• GSE300381 High-avidity Cathepsin G specific CAR-T cells for the treatment of Acute Myeloid Leukemia June 27, 2025
  Contributors : Tara Walhart ; Feifei Song ; Marta Biondi ; Simone Stucchi ; Guangming Li ; Patrick Peishun ; Kyogo Suzuki ; Elizabeth G Hunt ; Andrew Kennedy ; Jessica E Thaxton ; Tracy Withers ; Laura E Herring ; Courtney G Elliott ; Sally A Hunsucker ; Rania Tsahouridis ; Marta Serafini ; Leah Flick ; Eben I Lichtman ; Mark Woodcock ; Lishan Su ; Zhiyuan Y […]
• GSE299985 Lurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos June 27, 2025
  Contributors : Wentian Li ; Fang Wang ; Zhe Feng ; Qianqian Cheng ; Yuqing Huang ; Han Xiao ; Hongjian GongSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLurasidone, a second-generation antipsychotic, is widely used for treating schizophrenia and bipolar disorder due to its favorable metabolic profile. However, its pote […]
• GSE300393 Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome June 27, 2025
  Contributors : Karo De Rycke ; Marina Horvat ; Lisa Caboor ; Griet De Smet ; Marta Santana Silva ; Wouter Steyaert ; Matthias Van Impe ; Patrick Segers ; Julie De Backer ; Patrick SipsSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioFibrillin dysfunction in Marfan syndrome (MFS) causes severe cardiovascular complications, […]
• GSE300384 Comparative transcriptome analysis of JAZ4 knock-out plants (jaz4-1) and Col-0 Arabidopsis thaliana plants. June 27, 2025
  Contributors : Maeli Melotto ; Zachariah JaramilloSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTime point RNAseq analysis of jaz4-1 mutant vs Col-0 reveals dynamic JAZ4 mediated regulatory pathways.
• GSE300612 PANAD/C7orf25 interacts with NXF1 to promote CDK6 mRNA nuclear export and G1/S transition June 27, 2025
  Contributors : Jin-Yu Liu ; Huan-Hui Feng ; Shi-Mei ZhuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNuclear export factor 1 (NXF1) exerts mRNA transporter activity via binding to adaptors. We aimed to identify new NXF1 adaptors, and found that the R122/E125/G133/D139 amino acid residues of C7orf25 interacted with […]
• GSE300879 Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens June 27, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAging is one of the greatest risk factors for chronic diseases. Research on aging at the cellular level, especially in adult stem cells, is conducive to a comprehensive understanding of the molecular processes of aging. We performed multiple systematic genome-wide CRISPR i […]
• GSE300954 Influence of the autoinducer-2 dependent quorum sensing on gene expression of asymptomatic bacteriuria E. coli isolate 83972 June 27, 2025
  Contributors : Marla Keizers ; Michael Berger ; Ulrich DobrindtSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliTo analyze the effect of AI-2-dependent quorum sensing on gene expression at the transcriptional level of E. coli 83972, we performed an RNA-seq analysis of wild type strain and the lsr-complemented variant […]
• GSE273999 A 3D genome atlas of breast cancer progression June 27, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.