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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299856 Targeting the STING-NFκB Pathway via BTK Inhibition: A Dual-Mechanism Therapeutic Strategy Mitigating Neuronal and Microglial Dysfunction in Amyotrophic Lateral Sclerosis [scRNA-seq] June 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder with limited therapeutic interventions. We identified the cGAS-STING-NFκB pathway as a dual therapeutic target that combats both neuronal degeneration and neurotoxic glial activity in ALS. Util […]
- GSE299797 Establishment of a human inner ear model for evaluating diminished ototoxicity of gentamicin subtype C2b June 13, 2026Contributors : Jeong Minjin ; Stankovic KonstantinaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClinically used gentamicin, a widely used aminoglycoside antibiotic, is a mixture of 5 major subtypes and potentially differential contributions to the drug’s known ototoxicity. The gentamicin subtype C2b has been previous […]
- GSE304812 Oncogenic Ras signaling disrupts PRC2 via EED downregulation to drive oncogenic reprogramming and niche remodeling in squamous cell carcinoma June 13, 2026Contributors : Meng-Yen Li ; Aubrey Houser ; Paula Restrepo ; Andrew Ji ; Elena EzhkovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSquamous cell carcinoma (SCC) is a common epithelial malignancy, yet its epigenetic underpinnings remain poorly defined. Here, we identify the Polycomb Repressive Complex 2 (PRC2) as a k […]
- GSE299859 Targeting the STING-NFκB Pathway via BTK Inhibition: A Dual-Mechanism Therapeutic Strategy Mitigating Neuronal and Microglial Dysfunction in Amyotrophic Lateral Sclerosis [RNA-seq] June 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder with limited therapeutic interventions. We identified the cGAS-STING-NFκB pathway as a dual therapeutic target that combats both neuronal degeneration and neurotoxic glial activity in ALS. Util […]
- GSE269456 CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis June 13, 2026Contributors : Zaibiao Wang ; Zhipeng Yin ; Hao Li ; Heng ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in oncogenes such as KRAS, NRAS and BRAF promote cancer cell survival and proliferation, while excessive RAS/RAF/MEK/ERK signaling instead exerts an inhibitory effect on tumor growth. The precise regul […]
- GSE334772 NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis June 13, 2026Contributors : Zifan Zhao ; Ze-Yi Zheng ; Jonathan T Lei ; Matthew J Baik ; Yi-Hsuan Wu ; Lauren K Somes ; Andres F Mosquera Paternina ; Omar A Harb ; Owen A Chang ; Fengshuo Liu ; Matthew V Holt ; Junkai Wang ; Igor Bado ; Hai Wang ; George Miles ; Zbigniew Gugala ; Meenakshi Anurag ; Ahmed Elkhanany ; Yi Li ; Valentina Hoyos ; Xiang H Zhang ; Eric C ChangS […]
- GSE305735 Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues June 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCell and tissue functions arise from complex interactions among numerous genes, and a systematic understanding of these functions requires isoform-resolved transcriptomic analysis of single cells with high spatial resolution. Here, we introduce an in situ RNA amplification […]
- GSE287463 Single Cell Gene Expression Profiling of CD45+ Cells in Mouse Liver with or without MCD diet June 13, 2026Contributor : Xiaojun ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-Cell Sequencing Reveals Immune Cell Subtype Differences in Mouse Liver Between ND and MCD Treatment.
- GSE334646 ATAC-seq for proximal and distal colonic epithelial cells sorted from newborn and adult WT mice June 13, 2026Contributors : Mengqi Zheng ; Shiyang LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusATAC‑seq was conducted on sorted proximal and distal colonic epithelial cells derived from newborn and adult WT mice (n = 2 per group).
- GSE331505 Engineering Human PEG10-based Nanoparticles for RNA Self-packaging, Delivery and Cancer Therapy June 13, 2026Contributors : Pin-Yan Chen ; Ting-Lun Tien ; Vy Anh Truong ; Quyen Thuc Dang ; Nuong Thi Kieu Nguyen ; Pin-Hsin Chen ; Yu-Chen HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEngineered protein-based protein nanoparticles (PBNPs) were developed for RNA self-packaging and delivery. To characterize the RNA cargo compos […]
- GSE334648 The alteration of BA metabolism during development and inflammatory challenge June 13, 2026Contributors : Mengqi Zheng ; Shiyang LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo characterize alterations in bile acid metabolism under inflammatory conditions, RNA sequencing was conducted on proximal and distal colonic tissues from WT mice following 3 days of treatment with water or 3% DSS (n = 5 per group). […]
- GSE334731 Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in Fibrodysplasia Ossificans Progressiva (RNA-Seq) June 13, 2026Contributors : Ellen Zhang ; Sang Hyun Lee ; Inkyung Jung ; Su Chin HeoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder in which a recurrent ACVR1 (R206H) mutation drives progressive heterotopic ossification (HO). We combined super-resolution stochast […]
- GSE334754 Host infection selects for sRNA variants that drive bacterial social cheating June 13, 2026Contributors : Quentin Dubois ; Typhaine Brual ; Marcel Sprenger ; Kai Papenfort ; Laetitia Attaiech ; Erwan GueguenSeries Type : Expression profiling by high throughput sequencingOrganism : Dickeya solaniSingle-nucleotide mutations in regulatory small RNAs (sRNAs) represent a largely unexplored route to social cheating during bacterial infection. Here we sh […]
- GSE299746 Integrated miRNA-mRNA Analysis Reveals Regulatory Mechanisms of Muscle Fiber Transformation Underlying Meat Quality Variation in Chicken June 13, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusChicken muscle fibers are classified as oxidative or glycolytic, with distinct metabolic properties that influence meat quality. However, the molecular mechanisms linking fiber type to quality traits remain unclear. This study compared the pectoralis major (PEM) and soleu […]
- GSE305085 Oncogenic Ras signaling disrupts PRC2 via EED downregulation to drive oncogenic reprogramming and niche remodeling in squamous cell carcinoma [mouse RNA-Seq] June 13, 2026Contributors : Meng-Yen Li ; Xiang Yu Zheng ; Deyou Zheng ; Elena EzhkovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSquamous cell carcinoma (SCC) is a common epithelial malignancy, yet its epigenetic underpinnings remain poorly defined. Here, we identify the Polycomb Repressive Complex 2 (PRC2) as a key epigenetic […]