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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE192711 Comparison of transcriptional profiles of CD62L+ and CD62L- subsets of in vivo primed CD44hiCD4+ T cells by exposure to ovalbumin plus papain December 27, 2024Contributors : Jianguo Liu ; Linqing Du ; Shuying Yi ; Yan Lin ; Yanan Bi ; Lina Li ; Guangming Zhu ; Xiuli Jing ; Wengang Song ; Hua TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMemory type 2 CD4+ T helper (Th2) cells play critical roles in allergic asthma, but their generation and maintenance remain poorly unde […]
- GSE228746 Gene expression in 10 d Wild-type and Amh-cre Hdac3 KO Sertoli cells December 27, 2024Contributors : Mengrou Liu ; Lan YeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aims to explore the transcriptional changes in Sertoli cells depleted with HDAC3. Sertoli cells were isolated from wild-type and Amh-cre Hdac3 KO mice at postnatal day 10.
- GSE193185 Comparison of cyclic compressive stimulation and proinflammatory cytokine stimulation of three-dimensional cultured human articular chondrocytes December 27, 2024Contributor : Minami HikidaSeries Type : Expression profiling by arrayOrganism : Homo sapiensOsteoarthritis is a multifactorial disease in which not only physical tissue damage but also persistent inflammation is thought to be one of the main causes. The qualitative differences between mechanical and inflammatory cytokine stimulation in the production of OA- […]
- GSE250570 RNA-seq analysis of neuronal differentiation of KAT6A/B knockout mouse embryonic stem cells December 27, 2024Contributors : Marie Warburton ; Kimberly M Webb ; Elana Bryan ; Simon Andrews ; Philipp VoigtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPromoters of developmental genes in embryonic stem cells (ESCs) are marked by histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in an asymmetric nucleosomal conformation, […]
- GSE229987 Genome-wide distribution of KAT6B and H3K23ac in mouse embryonic stem cells December 27, 2024Contributors : Nwamaka J Idigo ; Kimberly M Webb ; Elana Bryan ; Valsakumar Devisree ; Simone Lenci ; Viktoria Major ; Marie Warburton ; Simon Andrews ; Philipp VoigtSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogaster ; Mus musculusPromoters of developmental genes in embryonic stem cells (ESCs) are […]
- GSE271110 Nuclear translocation of TfR1 facilitating tumor progression via p53-mediated gene regulation [Cut&Tag] December 27, 2024Contributors : Yaxin Hou ; Qizhi WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIt is well-known that p53-mediated gene regulation exerts a profound impact on the occurrence, progression, metastasis, and various other facets of tumor. Wherein, activation of p53 downstream DNA damage repair-related gen […]
- GSE271109 Nuclear translocation of TfR1 facilitating tumor progression via p53-mediated gene regulation [RNA-seq] December 27, 2024Contributors : Yaxin Hou ; Qizhi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt is well-known that p53-mediated gene regulation exerts a profound impact on the occurrence, progression, metastasis, and various other facets of tumor. Wherein, activation of p53 downstream DNA damage repair-related genes is able to […]
- GSE273408 CHRNA9 and MICU1 Govern the Potency of the Mitochondrial Permeability Transition Pore in Necroptotic Oral Cancer Progression December 27, 2024Contributors : Md I Faizan ; Tanveer AhmadSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur study included 30 tissue samples in total, which included 15 samples from OSCC patients, 10 from OSMF patients, and 5 normal control samples. To explore the involvement of genes associated with the changes observed in OSMF tiss […]
- GSE271155 Nuclear translocation of TfR1 facilitating tumor progression via p53-mediated gene regulation December 27, 2024Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE284211 Effect of porcine spermatogonia germ cells on de novo morphogenesis of testis trough xenotransplatation. December 27, 2024Contributors : Min-Gi Han ; Hyuk SongSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaThis study explores the role of porcine spermatogonia germ cells and testicular fibroblast in testis development and spermatogenesis through xenotransplantation. Previous research demonstrated the importance of Sertoli cells in maintainin […]
- GSE280924 Metformin Regulates Ferroptosis in Skin Cutaneous Melanoma December 27, 2024Contributors : Weiting Kang ; Da GuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo explore the effects of metformin on the proliferation and ferroptosis of skin cutaneous melanoma (SKCM) and its potential molecular mechanisms, providing a new theoretical basis and strategy for the treatment of cutaneous melanoma. RNA […]
- GSE284403 Lactylated histone promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies December 27, 2024Contributor : Gan WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe elevated lactate in the joint microenvironment of patients with rheumatoid arthritis (RA) is crucial for disease progression, although the underlying mechanism remains to be elucidated. In this study, we observed significantly increased global lacty […]
- GSE285206 Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNAThr production December 27, 2024Contributors : Jay H Chung ; Lorant SzekvolgyiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG-deficiency cau […]
- GSE285240 CGH: Rag2_and_Rsv1-h_recombinant_haplotype_analysis December 27, 2024Contributors : Robert M Stupar ; Adrian O Stec ; George L Graef ; Luis G PosadasSeries Type : Genome variation profiling by genome tiling arrayOrganism : Glycine maxSoybean lines were compared to the reference genome Williams 82 (Wm82) by CGH to catalog feature polymorphisms in a Rag2 and Rsv1-h QTL regionThe CGH comparisons reveal reveal feature polymorphis […]
- GSE285269 Spatial transcriptomics: P. aeruginosa corneal infection December 27, 2024Contributors : Hao Zhou ; Oscar Negrón ; Serena Abbondante ; Nicole Chumbler ; Eric Pearlman ; Mihaela GadjevaSeries Type : OtherOrganism : Mus musculusTo holistically unravel the complexity of pathogen-host interactions within infected tissues we leverage a dual spatial transcriptomic approach that, for the first time, simultaneously captures the expression […]