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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE240133 Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor July 12, 2025Contributors : Huanhuan Ma ; Qinxi Li ; Tingyan CaoSeries Type : Expression profiling by high throughput sequencingOrganism : MusHCC has a poor response to therapy and a bad prognosis with chronic inflammation be the most common etiologies for HCC progression. Here we report a redox-dependent regulation mechanism of PIR protein nuclear shuttling, leading to […]
- GSE270805 Transcriptome analyses of bEV treated HEK293T cells July 12, 2025Contributors : Joonghoon Park ; Seoah ParkSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo get insight of molecular effects of bEV on HEK293T cells, we investigated transcriptomic response in bEV treated HEK293T cellsWe identified differentially expressed genes (DEGs) fold change cutoff = 1.5 in the bEV treated HEK293T cellsThese findings […]
- GSE243140 Spatial transcriptomics reveals modulation of transcriptional networks across brain regions after auditory threat conditioning July 12, 2025Contributors : Joy Otten ; Dan Shu ; Torsten KlengelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrior research has demonstrated genome-wide transcriptional changes related to fear and anxiety across species, often focusing on individual brain regions or cell types. However, the extent of gene expression differences […]
- GSE301996 Identification of Novel DNA Sequence Motifs that Modulate Transcription in T cells July 12, 2025Contributors : Nicole Knoetze ; Scott D Brown ; Eric Yung ; Anthony Bayega ; Robert A HoltSeries Type : OtherOrganism : Homo sapiensConsiderable progress has been made towards associating transcription factor binding sites (TFBS) with cell-type-specific gene expression, however, the full repertoire of DNA sequence motifs that regulate transcription remains u […]
- GSE272121 CRISPRi Screening of Enhancers in Human Primary Astrocytes Identifies Regulatory Circuitry Disrupted in Alzheimer’s Disease July 12, 2025Contributors : Nicole F Green ; Gavin J Sutton ; Javier Pérez-Burillo ; Juli Wang ; Irina VoineaguSeries Type : SNP genotyping by SNP arrayOrganism : Homo sapiensWe used CROP-seq to perform a high-throughput, parallel screen of 979 candidate enhancer perturbations in normal human astrocytes (NHAs), a primary cell-line. We identified the target gene(s) for 14 […]
- GSE208148 RNA-seq: screening key metastasis-related RBP genes of hepatocellular carcinoma July 12, 2025Contributors : Yunyun Xiao ; Yue Li ; Dongni ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor metastasis is a major factor contributing to high mortality in patients with hepatocellular carcinoma (HCC). RNA binding protein (RBP)-mediated post-transcriptional regulation is involved in the precise control of signa […]
- GSE208025 RNA-sequencing analysis of aneurysmal tissues with or without treatment of targeted nanotherapy. July 12, 2025Contributors : Jianxiang Zhang ; Kaiyao HuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusOur study represents the first detailed analysis of aneurysmal tissues with or without our targeted nanotherapy, generated by RNA-seq technology. The optimized data analysis workflows reported here should provide a framework f […]
- GSE300498 Impact of dietary methionine, tryptophan, and niacin deficiency on intestinal gene expression in mice. July 12, 2025Contributors : Tomoaki Hara ; Sikun Meng ; Daisuke Motooka ; Yasuko Arao ; Yoshiko Saito ; Sarah Rennie ; Shizuka Uchida ; Ken Ofusa ; Takahiro Arai ; Masamitsu Konno ; Taroh Sthoh ; Hideshi IshiiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEmerging evidence indicates that selective nutrient restriction can reproduce […]
- GSE299945 Coinfection with Fowl Adenovirus Serotypes 1 and 4 (FAdV-1 and -4) Enhances FAdV-4 Replication through FAdV-1-mediated Upregulation of HSPA2 Expression July 12, 2025Contributors : xiaoxuan Li ; Miao Dan ; Dongying Liu ; Binbin Ren ; Yifan Ge ; Yayu Li ; Julian. A Hiscox ; James P. Stewart ; Qin Zhao ; Mingzhi Liao ; Yani SunSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusFowl adenoviruses (FAdVs) are widely distributed in poultry populations around the world, and many diseases are […]
- GSE301017 scRNA-seq analysis of intestinal gene expression in mice under methionine, tryptophan, and niacin-deficient diets July 12, 2025Contributors : Tomoaki Hara ; Sikun Meng ; Daisuke Motooka ; Yasuko Arao ; Yoshiko Saito ; Sarah Rennie ; Shizuka Uchida ; Ken Ofusa ; Takahiro Arai ; Masamitsu Konno ; Taroh Satoh ; Hideshi IshiiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEmerging evidence suggests that selective nutrient restriction can confer met […]
- GSE300499 Impact of dietary methionine, tryptophan, and niacin deficiency on gut microbiota in mice. July 12, 2025Contributors : Tomoaki Hara ; Sikun Meng ; Daisuke Motooka ; Yasuko Arao ; Yoshiko Saito ; Sarah Rennie ; Shizuka Uchida ; Ken Ofusa ; Takahiro Arai ; Masamitsu Konno ; Taroh Satoh ; Hideshi IshiiSeries Type : OtherOrganism : mouse gut metagenomeEmerging evidence indicates that selective nutrient restriction can reproduce metabolic benefits. Although methion […]
- GSE301701 Persistent impact of embryonic temperature on cellular metabolism in the developing Atlantic salmon liver revealed by single nuclei transcriptomics July 12, 2025Contributors : CIJ Milton ; RS Taylor ; J Sun ; CC Lazado ; NM Wade ; E Burgerhout ; DJ MacqueenSeries Type : Expression profiling by high throughput sequencingOrganism : Salmo salarEnvironmental temperature influences every biochemical and physiological process in poikilothermic fishes. Embryogenesis is a sensitive period of development where the thermal re […]
- GSE301829 A Liver-to-Skin Neuroimmune Axis Transmits Visceral Distress via Midkine-Driven Alloknesis July 12, 2025Contributors : Zihan Wang ; Yanyong Cheng ; Zili Xie ; Ting Wang ; Yuanyuan Ye ; Wenbo Jiang ; Yifei Liu ; Tianyi Shen ; Liyan Wu ; Lei Zhang ; Liqin Zhou ; Ximin Hu ; Hongfei Zhang ; Fengxian Li ; Heng Xu ; Jing FengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe skin, long considered as a passive barrier and targe […]
- GSE301903 Dppa2 synergizes with p53 in promoting DNA damage-induced apoptosis of mouse embryonic stem cells [ChIP-Seq] July 12, 2025Contributors : Sisi Xu ; Nan Chen ; Lu Chen ; Xiaojun Tan ; Mangmang LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDppa2 (Developmental pluripotency associated 2), specifically expressed in embryonic stem cells (ESCs) and reactivated in certain cancers, plays important roles in regulating the transitio […]
- GSE208249 Inhibition of lysine demethylase 6B blocks the development of ASXL1 truncation-mediated myeloid malignancies July 12, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.