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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE250243 Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis September 16, 2025Contributors : Lucy E Durham ; Elizabeth H Gray ; Frances Humby ; Nora Ng ; Sarah E Ryan ; Rosie Ross ; Giovanni A Povoleri ; Rosamond Nuamah ; Kathy Fung ; Athul Menon ; Pawan Dhami ; Bruce W Kirkham ; Leonie S TaamsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe hypothesised that skin and joint inflammation in psor […]
- GSE245731 HNF4G and FOXA1 are context-specific drivers of pancreatic cancer progression [ChIP-seq] September 16, 2025Contributors : Rao V Shalini ; Chernukhin Igor ; Carroll S JasonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusDespite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), clinical outcome remains poor. Previous work identified the pioneer transcription factor FOXA1 as a me […]
- GSE263106 Effect of muscle-specific Pex5 depletion on gene expression in gastrocnemius muscle September 16, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE262700 Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome September 16, 2025Contributors : Akisa Nemoto ; Kent Imaizumi ; Hirosato Ideno ; Hironobu Okuno ; Hideyuki OkanoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle cell gene expression profiling of PWS iPSC-derived hypothalamic organoids with and without epigenome editing. Raw data were not uploaded due to patient privacy concerns. […]
- GSE278439 An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA_(2/2) September 16, 2025Contributors : Kumiko Ui-Tei ; Seongjin AnSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate effects of siRNA with various 2'- modifications on genome-wide off-target effect, we analyzed gene expression profile of HeLa cells transfected by their siRNAs.
- GSE277309 Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma September 16, 2025Contributors : Elizabeth R Woodruff ; Courtney A Bailey ; Francis To ; Joanne K Maltzahn ; Timothy M Sullivan ; Meher P Boorgula ; Dwight J Klemm ; Benjamin G Bitler ; Zachary L WatsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we examined the influence of hematopoietic stem cell derived adipocytes (HS […]
- GSE307819 Transposable elements as catalysts of genome evolution in Drosophila virilis September 16, 2025Contributors : Alexander P Rezvykh ; Sergei Y FunikovSeries Type : Expression profiling by high throughput sequencing ; Other ; Non-coding RNA profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila virilisTransposable elements (TEs) drive genomic innovation, but their dynamics in non-mo […]
- GSE284628 RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria [CRASP-Seq] September 16, 2025Contributors : Amit K Behera ; Jeongjin J Kim ; Shreya Kordale ; Filip Pekovic ; Arun P Damodaran ; Bandana Kumari ; Sandra Vidak ; Ethan Dickson ; Mei S Xiao ; Gerard Duncan ; Thorkell Andresson ; Tom Misteli ; Eugene Valkov ; Thomas Gonatopoulos-PournatzisSeries Type : OtherOrganism : Homo sapiensDespite progress in understanding pre-mRNA splicing, the reg […]
- GSE307831 Human peripheral and tissue Foxp3-high regulatory T cells in patients with hepatocellular carcinoma [CITE-seq] September 16, 2025Contributors : Chien-Hao Huang ; Wei-Ting Ku ; Jayashri Mahalingam ; Cheng-Heng Wu ; Tsung-Han Wu ; Jian-He Fang ; Chung-Wei Su ; Po-Ting Lin ; Chien-Wei Peng ; Chan-Keng Yang ; Wei Teng ; Wen-Juei Jeng ; Wei-Ting Chen ; Chen-Chun Lin ; Shi-Ming Lin ; I-Shyan Sheen ; Yung-Chang Lin ; Chun-Yen LinSeries Type : Expression profiling by high throughput sequencin […]
- GSE307823 Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes September 16, 2025Contributors : Gabriele Sassi ; Pierre Lemaitre ; Chantal Mathieu ; Conny GysemansSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTeplizumab, a humanized anti-CD3 monoclonal antibody, represents a major advancement in autoimmune type 1 diabetes (T1D) treatment, capable of delaying clinical onset in stage 2 and p […]
- GSE307844 RNA-seq of THP-1 and U937 exposed to enamel matrix derivative. September 16, 2025Contributors : Panahipour Layla ; Xiaoyu Huang ; Reinhard GruberSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEnamel matrix derivatives (EMDs) treat periodontal defects and gingival recession, a process where macrophages are believed to contribute to the clinical outcome. However, the present findings are heterogeneou […]
- GSE307852 Disruption of Pre-Bötzinger Complex neuropeptidergic tonality controls fear and metabolic response September 16, 2025Contributor : Prashant RajbhandariSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStress profoundly impacts systemic metabolism, yet the central circuits linking stress responses to peripheral metabolic regulation remain poorly defined. Here, we identify the preBötzinger complex (preBötC), a brainstem breathing rhythm g […]
- GSE307947 Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [ATAC-Seq] September 16, 2025Contributors : Shashank Srivastava ; Daniel R FoltzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensFundamental cellular processes including replication, transcription, and repair rely on both an adequate nucleotide supply and sufficient availability of new histones. Chromatin disassembly and reassembly is […]
- GSE239520 Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents [TSC] September 16, 2025Contributors : Shota Nishitani ; Akemi TomodaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensChild maltreatment (CM) is associated with adverse physical, psychological, and neurodevelopmental outcomes later in life. Epigenetic modifications, particularly DNA methylation, have been proposed as potential mechanisms underlying t […]
- GSE307813 Nanoscale photoproximity labeling of c-Myc predicts cancer specific therapeutic targets September 16, 2025Contributors : Ryan R Milione ; Feifei Tong ; Kelset L Wolfe ; Pfizer Pfizer ; Michalina Janiszewska ; Ciaran P SeathSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscription factors (TFs) have long been aspirational therapeutic targets for the treatment of diseases, as their dysregulation is a common mechanism for […]