Gene Expression Omnibus Announcements -Study Releases

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE252020 Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [RNA-seq] June 30, 2025
  Contributors : Elkyn Estupiñán-Moreno ; José Hernández-Rodríguez ; Tianlu Li ; Laura Ciudad ; Eduardo Andrés-León ; Laura C Terron-Camero ; Sergio Prieto-González ; Georgina Espígol-Frigolé ; Maria C Cid ; Ana Márquez ; Javier Martín ; Esteban Ballestar ; Lourdes Ortiz-FernándezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo s […]
• GSE248474 Transcriptome-wide profiles in RA FLS with NAT10 knockdown June 30, 2025
  Contributor : Di LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFibroblast-like synoviocytes (FLS) exhibit aggressive phenotype, proliferation and decreased cell-contact inhibition,and play a critical role in pathogenesis of rheumatoid arthritis (RA). However, the mechanism underlying these phenotype remains unknown […]
• GSE267797 METTL14 promotes retinal neovascularization via m6A-modification on MXD1 mRNA in oxygen induced retinopathy June 30, 2025
  Contributor : Xianyang LiuSeries Type : OtherOrganism : Homo sapiensIn this study, we explored the effects and underlying mechanisms of methyltransferase-like 14 (METTL14) in microglia cell line (HMC3 cells), which are crucial for the pathogenesis of Retinopathy of Prematurity (ROP). Our results showed that the expression of METTL14 was increased in HMC3 cel […]
• GSE256326 Myeloid mimicry mediates hyperprogression in patients with renal medullary carcinoma treated with nivolumab plus ipilimumab June 30, 2025
  Contributors : Jianfeng Chen ; Xinmiao Yan ; Jianjun Gao ; Linghua Wang ; Giannicola Genovese ; Pavlos MsaouelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRenal medullary carcinoma (RMC) is a rare but highly aggressive malignancy that mainly afflicts young individuals of African descent and has few treatment options. […]
• GSE273682 Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing June 30, 2025
  Contributors : Maria S Roman Azcona ; Gianni Monaco ; Masako M Kaufmann ; Toni Cathomen ; Claudio MussolinoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEngineered T cells equipped with a chimeric antigen receptor (CAR) have shown tremendous clinical success but tumor-mediated stimulation of T cell inhibitory receptor […]
• GSE270250 Comprehensive analysis of Bulk RNA-seq and Single-nuclei RNA-seq reveals the origin of high-grade serous “ovarian” carcinoma [snRNA-seq] June 30, 2025
  Contributors : keren cheng ; Wei YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh grade serous ovarian cancer (HGSOC) is characterized by late stage, rapid progression, easy drug resistance, high mortality and recurrence rate.Tubal secretory cells have always been considered as the origin cells of HGSOC,due to th […]
• GSE300780 Transcriptomic analysis explore the molecular mechanism of enhancement of Ponceau 2R decolorization by Trametes hirsuta X-13 after addition of sinapic acid June 30, 2025
  Contributors : Jiangshan Ma ; Han Yang ; Rui Feng ; Yujiang Qin ; Haoling Hu ; Gao-Qiang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Aspergillus fumigatusTo investigate the molecular mechanism underlying the effect of sinapic acid on the decolorization of Ponceau 2R by T. hirsuta X-13, comparative transcriptomic analyses wer […]
• GSE207864 RNA-seq of equine alveolar macrophages and blood monocyte-derived macrophages exposed to an inflammatory stimulus June 30, 2025
  Contributors : Heng Kang ; Gary K Lee ; Dorothee Bienzle ; Jutta Hammermueller ; Luis A Castro ; Brandon Lillie ; Janet Beeler-MarfisiSeries Type : Expression profiling by high throughput sequencingOrganism : Equus caballusThe obejective was to investigate how equine alveolar macrophages (AMs) and monocyte-derived macrophages (MDMs) response to a stimuli whi […]
• GSE300847 Effect of FL-Fc-DM1 drug on gene expression of MV-4-11 cells. June 30, 2025
  Contributors : Dengyang Zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo eliminate cell-cycle arrested AML cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the MV-4-11 cells as a AML model. The total mRNA of MV-4-11 cells treated with different c […]
• GSE300846 Effect of FL-Fc-DM1 drug on gene expression of Molm-13 cells June 30, 2025
  Contributors : Dengyang zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo eliminate cell-cycle arrested AML cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the Molm-13 cells as a AML model. The total mRNA of Molm-13 cells treated with different c […]
• GSE300849 Effect of FL-Fc-DM1 drug on gene expression of THP-1 cells June 30, 2025
  Contributors : Dengyang zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo eliminate cell-cycle arrested AML cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the THP-1 cells as a AML model. The total mRNA of THP-1 cells treated with different conce […]
• GSE300900 Plasma extracellular vesicle-derived miR-296-5p is a maturation-dependent rejuvenation factor that downregulates inflammation and improves survival after sepsis June 30, 2025
  Contributors : Lun Cai ; Parmita Kar ; Yutao Liu ; Xiaogang Chu ; Ashok Sharma ; Tae Jin Lee ; Raghavan P Raju ; Ali ArbabSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusThere is a progressive decline in physiological function with age, and aging is associated with increased susceptibility to injury and infection. H […]
• GSE300904 Effect of FL-Fc-DM1 drug on gene expression of Molm-13 cells pretreated with cytarabine. June 30, 2025
  Contributors : Dengyang Zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCytarabine is one of the first line chemo drugs to treat acute myeloid leukemia (AML). However, cytarabine can induce AML cell cell cycle arrest at G0/G1 phase. These cell-cycle-arrested AML cells resist cytarabine, show a senescence […]
• GSE235190 Sterile alpha motif domain-containing protein 9 is an RNA binding protein impacting ribosome biogenesis and interferon signaling June 30, 2025
  Contributors : Paul Hoover ; Marisol Ramirez-Solano ; Qi Liu ; Jason R SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInherited bone marrow failure syndromes often result from pathogenic mutations in genes that are important for ribosome function, namely, Diamond-Blackfan anemia, Shwachman-Diamond syndrome, and […]
• GSE300685 Tumor-infiltrating natural killer cell profiling for therapeutic stratification in smokers with resectable non-small cell lung cancer June 30, 2025
  Contributors : Hyun-sung Lee ; Sung Wook KangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObjective: Neoadjuvant chemoimmunotherapy has improved outcomes in resectable non-small cell lung cancer (NSCLC), yet its real-world implementation is often challenged by surgical delays, cancellations, immune-related fibrosis, […]