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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE246877 Steroid receptor coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress October 29, 2024Contributors : Lisa McClendon ; Rainer B LanzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe recently discovered that steroid receptor coactivators (SRCs) SRCs-1, 2 and 3, are abundantly expressed in cardiac fibroblasts (CFs) and their activation with the SRC small molecule stimulator MCB-613 improves cardiac functio […]
- GSE261066 Transient promoter interactions modulate developmental gene activation [RNA-Seq] October 29, 2024Contributors : Angelika Feldmann ; Sonja Pruessing ; Susannah Holliman ; Valeriia Smialkovska ; Helena BorgersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptional induction coincides with the formation of various chromatin topologies, including loss and gain of physical interactions between promoters and enha […]
- GSE261039 Transient promoter interactions modulate developmental gene activation [ChIPseq] October 29, 2024Contributors : Angelika Feldmann ; Sylvia Mahara ; Samuel Krall ; Helena Borgers ; Sonja PruessingSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTranscriptional induction coincides with the formation of various chromatin topologies, including loss and gain of physical interactions between promoters and di […]
- GSE262468 Gene expression profile of FACS sorted cranial neural crest cells from E12.5-E13.5 mouse embryonic head October 29, 2024Contributors : Michaela Krausova ; Pavel Abaffy ; Ondrej MachonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCraniofacial morphogenesis depends on complex cell fate decisions during the differentiation of post-migratory cranial neural crest cells. Molecular mechanisms of cell differentiation of mesenchymal cells to de […]
- GSE262180 RNAseq analysis of sex differences of young and old hematopoietic stem cells October 29, 2024Contributors : Chunxiao Zhang ; Taisen Hao ; WenYong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA sequencing (RNAseq) analysis of hematopoietic stem/progenitor cells purifiied from young and longevity mice, both male and female.
- GSE188452 RNAsequencing of plasma cells generated ex vivo upon 2 days of LPS stimulation on WT and Sec22B-KO plasma cells October 29, 2024Contributors : Marion Espéli ; Amélie BonaudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report RNAseq data obtains from ex vivo generated plasma cell after 2 days of stimulation with LPS. We compare WT plasma cells to Sec22bB-KO plasma cells. Sec22b KO is specific of B cell lineage. We find over 6000 genes differ […]
- GSE264500 New weapons explosive exhibits persistent toxicity in plants October 29, 2024Contributors : Nicola Oates ; Edward Nay ; Tim Cary ; Elizabeth Rylott ; Neil BruceSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaExplosives are widespread, toxic and persistent environmental pollutants. 2,4-Dinitroanisole (DNAN) is being phased in to replace 2,4,6-trinitrotoluene (TNT) in munitions. Here we de […]
- GSE277452 Effects of tofacitinib and takinib on autoimmune pancreatitis in mice October 29, 2024Contributor : Robert JasterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUsing a mouse model of autoimmune pancreatitis (AIP), we investigated two potential alternatives to steroid treatment, the transforming growth factor-β-activated kinase 1 (TAK1) inhibitor takinib, and the Janus kinase (JAK) inhibitor tofacitinib. […]
- GSE276682 Single-cell transcriptome analysis revealed cellular reprogramming following Tetramethylpyrazine treatment in LPS-induced acute lung injury October 29, 2024Contributors : Mingyan Wu ; Shanmei Wang ; Xiaolan Chen ; Shen li ; Jurong Ding ; Hongbin JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTetramethylpyrazine (TMP) has shown potential in the treatment of acute respiratory infections. We used single-cell RNA sequencing to investigate the mechanism and potential ther […]
- GSE278936 Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer October 29, 2024Contributors : Matti Nykter ; Alfonso UrbanucciSeries Type : OtherOrganism : Homo sapiensProstate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated the mechanisms through which cancer cells escape treatment, but their relation toward the tumor microenvironment (TME) remains […]
- GSE278302 Enhanced combination treatment on osteosarcoma by mitigating drug-induced oncogenic signaling pathway activation October 29, 2024Contributors : Zhihong Li ; Chao Tu ; Wenchao Zhang ; Lin QiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOsteosarcoma is a prevalent primary malignant bone tumor in children and young adults, with limited progress in improving survival rates for metastatic or recurrent cases. Kinase inhibitors emerged as potential tr […]
- GSE279759 VIRMA-mediated m6A modification regulates forebrain formation through facilitating ribosome biogenesis October 29, 2024Contributors : Tao Zhou ; Min Wu ; Bin Shen ; Haifeng Sun ; Xiaoli WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusN6-methyladenosine (m6A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m6A modification and their impact on protein synt […]
- GSE279807 RNA-seq of Myla cell line after FOXM1 knockdown October 29, 2024Contributors : Kecen Liu ; Jingru SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFOXM1 is a vital transcription factor associated with proliferation, expressed extensively and dynamically throughout the cell cycle. Its overexpression in mycosis fungoides correlates with a poor prognosis. However, the specific role o […]
- GSE280202 Effects of oxygen consumption rate and ammonia excretion rate and transcriptome analysis of Mactra veneriformis with different shell colors under ocean acidification stress October 29, 2024Contributors : Limei Chen ; Gengyin HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mactra quadrangularisIn recent years, increasing levels of dissolved carbon dioxide in seawater have led to an increase of ocean acidification (OA), which constitutes a major threat to marine ecosystems. As an important economically marine biva […]
- GSE236639 ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner October 29, 2024Contributors : Tim M Wunderlich ; Chandrika Deshpande ; Lena W Paasche ; Tobias Friedrich ; Felix Diegmüller ; Elias Haddad ; Carlotta Kreienbaum ; Haniya Naseer ; Sophie E Stebel ; Nadine Daus ; Jörg Leers ; Jie Lan ; Van Tuan Trinh ; Olalla Vázquez ; Falk Butter ; Marek Bartkuhn ; Joel P Mackay ; Sandra B HakeSeries Type : Expression profiling by high thro […]