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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE311639 FACT Complex Recruitment and the Role of H2A.Z in Transcriptional Regulation December 24, 2025Contributors : Israel Ausin ; Yafei Wang ; weiye Qian ; Chao XuSeries Type : OtherOrganism : Arabidopsis thalianaThe FACT complex (FAcilitates Chromatin Transcription) plays a key role in chromatin remodeling during transcription, enhancing DNA accessibility. It is believed to alter chromatin by temporarily displacing histones, enabling RNA polymerase II (Po […]
- GSE314452 Luspatercept with Immunosuppression Reducess Inflammation in Patients with Severe Aplastic Anemia by Inhibiting Monocyte Pyroptosis [RNA-Seq] December 24, 2025Contributors : Zining Wang ; Jiaming Hu ; Yiyu Guo ; Xinrui Zhang ; Yu Gao ; Nan Song ; Rong FuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAplastic anemia (AA) is a bone marrow failure disorder caused by diverse etiologies. AA pathogenesis involves aberrant immune activation and an imbalanced inflammatory bone marro […]
- GSE314358 Gene expression profiles in S2-007, S2-020 and S2-028 pancreatic ductal adenocarcinoma cell lines December 24, 2025Contributors : Hirotoshi Mochida ; Tomohiko Sakabe ; Yoshihisa UmekitaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the subcellular localization of maspin in pancreatic ductal adenocarcinoma (PDAC) and its functional relevance, gene expression profiles were analyzed in S2-007 (expressing nuclear and cyt […]
- GSE314634 Reciprocal interactions between EMT and BMP signalling drive collective cell invasion. December 24, 2025Contributors : Yuri Takahashi ; Alexandra Neaverson ; Lara C Busby ; Benjamin J SteventonSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusDuring collective cell invasion, epithelial-to-mesenchymal transition (EMT) and morphogen signalling-mediated cell fate specification are traditionally viewed as a linear cascade: mor […]
- GSE314453 Luspatercept with Immunosuppression Reducess Inflammation in Patients with Severe Aplastic Anemia by Inhibiting Monocyte Pyroptosis [scRNA-Seq] December 24, 2025Contributors : Zining Wang ; Jiaming Hu ; Yiyu Guo ; Xinrui Zhang ; Yu Gao ; Nan Song ; Rong FuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAplastic anemia (AA) is a bone marrow failure disorder caused by diverse etiologies. AA pathogenesis involves aberrant immune activation and an imbalanced inflammatory bone marro […]
- GSE296747 Leveraging Natural Variation and Yeast Genetics for Novel Insights on the Molecular Basis of Cytotoxicity for Parkinson's Related Protein alpha-Synuclein December 24, 2025Contributors : Julio A Molina Pineda ; Manasa Velovolu ; Tara N Stuecker ; Stephan N Witt ; Jeffrey A LewisSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeParkinson’s disease (PD) is a progressive neurodegenerative disorder affecting more than 5 million people worldwide. A hallmark of PD is dopaminergic neur […]
- GSE285688 Aortic valve calcification is induced by the loss of ALDH1A1 and can be prevented by agonists of retinoic acid receptor alpha: preclinical evidence for drug repositioning December 24, 2025Contributor : Mickael RosaSeries Type : Expression profiling by arrayOrganism : Homo sapiensStudy the effect of Am80 on osteoblast differentiation
- GSE314527 ChIP-seq experiment of transcription factor NFAT in Diaphorina citri December 24, 2025Contributors : Yu Du ; Mengle Sun ; You Li ; Taiyun WeiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Diaphorina citriChIP-seq experiment of transcription factor NFAT in Asian citrus psyllid Diaphorina citri. This experiment will figure out what gene was transcripted by NFAT in Diaphorina citri
- GSE314522 Chronic acidosis drives reversible metabolic plasticity and survival adaptation in multiple myeloma December 24, 2025Contributor : Wun-Shaing W ChangSeries Type : Expression profiling by arrayOrganism : Homo sapiensMultiple myeloma (MM) is a plasma cell malignancy that evolves within the complex bone marrow microenvironment, where sustained extracellular acidosis remains an underexplored but biologically significant stressor. To investigate the long-term impact of acidotic […]
- GSE314590 Ex Vivo Hypothermic Perfusion Enables 48-Hour Heart Preservation and Bench-Top Functional Recovery via Normothermic Reperfusion in a Porcine Model December 24, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaBackground: Ex vivo oxygenated perfusion systems is a promising approach to extend cardiac allograft preservation beyond the typical 4–6h limit allowed by static-cold-storage (SCS). Hypothermic oxygenated perfusion (HOPE) has been proven to safely preserve donor hearts, yet […]
- GSE314530 Expression data from HEK-293 cells treated with different CDK8/19 inhibitors December 24, 2025Contributors : Angga Prawira ; Yi NiSeries Type : Expression profiling by arrayOrganism : Homo sapiensHepatitis delta virus (HDV) enters hepatocytes via the receptor NTCP and requires CDK8/19 Mediator kinases to establish its infection by RNA Polymerase II. Here, we are interested in assessing the class effect of various CDK8/19 inhibitors and investigating […]
- GSE314624 WSTF deficiency reprograms regulatory networks by linking locus‑specific chromatin remodeling to altered isoform expression and misdirected signaling [CUT&Run] December 24, 2025Contributors : Shahin Behrouz Sharif ; Jonathan H DennisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLoss of the chromatin remodeler WSTF (BAZ1B), a gene deleted in Williams syndrome, causes reproducible, genome-scale reprogramming of chromatin states and transcript processing that links altered chromat […]
- GSE314625 WSTF deficiency reprograms regulatory networks by linking locus‑specific chromatin remodeling to altered isoform expression and misdirected signaling [mRNA-seq] December 24, 2025Contributors : Shahin Behrouz Sharif ; Jonathan H DennisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLoss of the chromatin remodeler WSTF (BAZ1B), a gene deleted in Williams syndrome, causes reproducible, genome-scale reprogramming of chromatin states and transcript processing that links altered chromatin composition […]
- GSE314626 Spatial genome organization is associated with nematode programmed DNA elimination December 24, 2025Contributors : James R Simmons ; Jianbin WangSeries Type : OtherOrganism : Ascaris suumProgrammed DNA elimination (PDE) is a notable exception to genome integrity, characterized by significant DNA loss during development. In many nematodes, PDE is initiated by DNA double-strand breaks (DSBs), which lead to chromosome fragmentation and subsequent DNA loss. Ho […]
- GSE303609 Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation December 24, 2025Contributors : Grace A. Osborne ; J. Michelle KahlenbergSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDermatomyositis (DM) is a rare yet devastating autoimmune disease characterized by inflammatory and vasculopathic changes in skin and muscle. DM and systemic lupus erythematosus (lupus) skin lesions have overlapping c […]