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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE276878 UTP15 recognizes nascent RNAs transcriptionally regulated by NANOG to maintain the pluripotency circuitry [Nascent RNA-seq] October 23, 2025Contributors : Mingqiang Deng ; Dongmei He ; Xiwei Wang ; Xichen BaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMaster transcription factor (mTF) has been recognized as topmost regulatory hierarchy in cell fate determination. However, the direct transcriptional targets of mTFs, and how the interplay between these tr […]
- GSE279804 High-Yield Extruded Nanovesicles from Adipose Stem Cells Promote High-quality Healing of Diabetic Wound through WNT/beta-Catenin Pathway Activation. October 23, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDiabetes is a significant global chronic disease characterized by elevated mortality and disability rates due to persistent infections resulting from refractory wounds. Currently, effective treatment strategies are lacking. Adipose-derived stem cell extracellular vesicles […]
- GSE277237 Characterization of the CCR4-NOT complex subunits CNOT1 and CNOT4 using rapid auxin-induced degradation in cultured cells October 23, 2025Contributors : Shardul Kulkarni ; Aswathy Sebastian ; Joseph ReeseSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCCR4-NOT regulates multiple steps in gene regulation, including transcription, mRNA decay, protein ubiquitylation and translation. Originally discovered in yeast, this complex is highly conserved across euka […]
- GSE309711 RNA-seq of superficial-zone articular cartilage in a DMM-induced osteoarthritis mouse model October 23, 2025Contributors : Yoshifumi Takahata ; Shiori Yamamoto ; Riko NishimuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusC57BL/6J male mice underwent destabilization of the medial meniscus (DMM) or sham surgery. Superficial-zone cartilage from the medial femoral condyle was microdissected 8 weeks postoperatively. Total RNA w […]
- GSE280108 Testosterone exposure during fetal masculinization programming window determines the kidney size in adult mice October 23, 2025Contributors : Arttu Junnila ; Mats Perk ; Asta Laiho ; Petra SipiläSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo study the role of fetal testosterone exposure in the development of male mouse kidney, we compared fetal kidneys from WT and testosterone deficient Hsd17b3 KO mice at E16.5, after 2 day testosterone pro […]
- GSE274363 H3K36 Methylation - a Guardian of Epigenome Integrity [ATAC-seq] October 23, 2025Contributors : Reinnier Padilla ; Gerald A Shipman ; Cynthia Horth ; Michel Gravel ; Eric Bareke ; Jacek MajewskiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusH3K36 methylation is a key epigenetic mark with critical roles in development and disease, yet its genome-wide functions remain inc […]
- GSE246090 DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity October 23, 2025Contributors : Hao Chen ; Li Fan ; Qi Guo ; Man Y Wong ; Fangmin Yu ; Nessa Foxe ; Winston Wang ; Aviram Nessim ; Gillian Carling ; Bangyan Liu ; Chloe Lopez-Lee ; Yige Huang ; Sadaf Amin ; Sue-Ann Mok ; Won-min Wong ; Bin Zhang ; Flint Beal ; Qin Ma ; Hongjun Fu ; Li Gan ; Wenjie LuoSeries Type : Expression profiling by high throughput sequencingOrganism : […]
- GSE304045 Type I and Type II fibre-type-specific and whole muscle DNA methylation profiles across both males and females before and after 12 weeks High Intensity Interval Training October 23, 2025Contributors : Nir Eynon ; Andrew S PalmerSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensSkeletal muscle is an important organ for health and movement, largely driven by specific muscle fibres. However, the assessment of fibre-type-specific DNA methylation in human skeletal muscle has been limited. We generated methylome pro […]
- GSE301197 Analysis of genomic changes induced by the shape of ZnO nanoparticles October 23, 2025Contributors : Bartlomiej Dominiak ; Julita Rosowska ; Agnieszka Wal ; Alicja Majewska ; Bartlomiej S Witkowski ; Anna Slonska-Zielonka ; Joanna Cymerys-Bulenda ; Mikolaj A Gralak ; Marek Godlewski ; Michal M GodlewskiSeries Type : Expression profiling by arrayOrganism : Gallus gallusResults of microarray analysis performed to test the effect of ZnO nanopart […]
- GSE305979 Perturbational single-cell RNA-seq time course of CD34+ HSPC megakaryocyte differentiation with CMO multiplexing (Days 0–7, 1 uM compounds) October 23, 2025Contributors : Inna Lipchina ; Daniel Burkhardt ; Charlotte Nesbitt ; Samuel Miller ; Benjamin DeMeo ; Thomas Pfefer ; Doris Fu ; Mauricio CortesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe profiled transcriptomic responses of a panel of small molecules during in vitro megakaryocyte (Mk) differentiation of CD34+ h […]
- GSE305370 Multimodal Single-Cell Integration Across Time, Individuals, and Batches October 23, 2025Contributors : Allegra Lord ; Samuel Miller ; Sunil Kuppasani ; Aakash Kabbin ; Benjamin DeMeo ; Jonathan Bloom ; Peter Holderrieth ; Hiyab Stefanos ; Qing Liu ; Kaylie Scheneider ; Cameron Reilly ; Aquib Hasnain ; Ethan French ; Karen Gaffney ; Aishwarya Chandler ; Mrunali Manjrekar ; Sophie Guo ; Yash Raj ; Sakina Saif ; Laura Issaco ; Scott Steelman ; Dan […]
- GSE306429 Perturbational single-cell RNA sequencing of 104 compounds across six immortalized and four primary cell lines October 23, 2025Contributors : Daniel Treacy ; John Bradley ; Laura Isaaco ; Kaylie Schneider ; Sakina Saif ; Scott Steelman ; Jonathan Bloom ; Benjamin DeMeo ; Corey Hayford ; Maximilian Rogers-Grazado ; Mauricio CortesSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapienswei introduce a new perturbational scRNA-seq dataset that inc […]
- GSE308379 Cutibacterium acnes induces skin region-specific innate immune memory alterations in human keratinocytes October 23, 2025Contributors : Fanni Balogh ; Anett Magyari ; Lilla Erdei ; Beáta Szilvia Bolla ; Balázs Koncz ; Laura Bagi ; Máté Manczinger ; Blanka Toldi ; Bálint Baráth ; Katalin Burián ; Rolland Gyulai ; Lajos Kemény ; Kornélia SzabóSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExternal insults can cause immune activation in imm […]
- GSE309118 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice October 23, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE274367 H3K36 Methylation - a Guardian of Epigenome Integrity October 23, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; Other ; Methylation profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.