Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE236259 Macrophage Regnase-3 limits tissue inflammation and injury via alternative splicing of pre-mRNA August 18, 2025
  Contributors : Chenyu Li ; Hans-Joachim AndersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-binding proteins regulate posttranscriptional gene translation regulate but little is known about the cell type-specific functions of Regnase3. Here, we characterized the role of Regnase3 in macrophages using RankCre-Regnas […]
• GSE212400 EZH2 reads DNA 6mA to regulate survival and drug resistance of human head and neck squamous carcinoma by suppressing RIOX2-CDKN1A-NRF2 signaling axis [ChIP-MeDIP-seq] August 18, 2025
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Homo sapienswe attempted to comprehensively assess whether EZH2 recognizes 6mA modification at the global level.We first performed chromatin immunoprecipitation following sequencing (ChIP-seq) in human HNSCCs using an […]
• GSE274646 AVJ16 inhibits IGF2BP1 in lung adenocarcinomas and prevents tumor growth in mice August 18, 2025
  Contributors : Nadav Wallis ; Tehila Gershon ; Sojod Shaaby ; Froma Oberman ; Myriam Gruenwald ; Deborah Duran ; Gilad Vainer ; Vladimir S Spiegelman ; Arun K Sharma ; Joel K YisraeliSeries Type : OtherOrganism : Homo sapiensIgf2bp1 is an oncofetal RNA binding protein that is expressed in a wide variety of tumors. We have recently described a small molecule […]
• GSE260521 Lung scRNAseq from lung fibroblastic cells from normal chow and high fat diet treated animals August 18, 2025
  Contributors : Sophia Rottmann ; Veronika Lukacs-KornekSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibroblastic stroma was isolated using MACS (negative selection for CD45, CD31 and Epcam)
• GSE278413 Nanopore RNAseq profiling of female wildtype or Malat1-/- naïve CD4+ T cells and in vitro differentiated Th2 cells for 2 days. August 18, 2025
  Contributors : Dimitris Lagos ; Mags GwynneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptomic profiling of Malat1-deficient and WT CD4+ T cells at Day 0 (naïve CD4+ T cells) and Day 2 post-induction of differentiation under Th2 conditions. Naive CD4+ T cells isolated from spleens and lymphnodes of female mic […]
• GSE275286 Transcriptional analysis of dendritic cells upon TLR stimulation reveals an immunosuppressive profile (N279 scRNA-Seq) August 18, 2025
  Contributors : Ling Wang ; Xiaoli Liu ; Cliff Y YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDendritic cells (DCs) simultaneously prime and dampen the immune response. The transcriptional program that regulates immunosuppression in DCs is currently unknown. Here we identified ETS homologous factor as a key transc […]
• GSE305163 Functional, sustained recovery of hearing in Otoferlin-deficient mice using DB-OTO, a hair cell-specific AAV based dual vector gene therapy August 18, 2025
  Contributors : Yoojin Chung ; Seth D Koehler ; Sarah Cancelarich ; Tyler M Gibson ; Gabriela Pregernig ; Lars Becker ; Quynh-Anh Artinian ; Joseph W Goodliffe ; Ning Pan ; Tera Quigley ; Arun Senapati ; Peter G Slade ; Lillian M Smith ; Kathy S So ; Xichun Zhang ; Carleton E Corrales ; Peter Weber ; Lynn E Macdonald ; Brian Zambrowicz ; Aris N Economides ; C […]
• GSE281782 Novel therapeutic strategy targeting STMN1 using chlorambucil-conjugated pyrrole-imidazole polyamide in small cell lung cancer August 18, 2025
  Contributors : Ryohei Yoshikawa ; Takayoshi Watanabe ; Yoichi Ohtaki ; Toshikazu Bando ; Hiroshi Sugiyama ; Takuya Araki ; Hideaki Yashima ; Bilguun Erkhem-Ochir ; Haruka Okami ; Gendensuren Dorjkhorloo ; Ikuma Shioi ; Toshiteru Nagashima ; Natsuko Kawatani ; Tomohiro Yazawa ; Eiji Narusawa ; Takayuki Kosaka ; Osamu Kawashima ; Mitsuhiro Kamiyoshihara ; John […]
• GSE305223 RNA sequencing analysis of embryos exposed to nanoplastics: effects on developmental and transcriptomic alteration August 18, 2025
  Contributors : Hyeong-Ju You ; Yu-Jin Jo ; Jeongwoo Kwon ; Seung-Bin Yoon ; Changsic Youn ; Yejin Kim ; Man-Jong Kang ; Ji-Su KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe increasing prevalence of nanoplastics (NPs) in the environment has raised concerns regarding their potential risks to ecosystems and human h […]
• GSE305216 Decoding cellular stress states for toxicology using single-cell transcriptomics August 18, 2025
  Contributors : Brian N. Chorley ; Imran Shah ; Dennis J. EastburnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell transcriptomics (SCTr) offers a powerful platform for decoding the complexities of cellular stress responses to chemical exposures, capturing rare and transient subpopulations that can be obscured […]
• GSE305284 Dads matter, too: The behavioural and neurogenomic effects of receiving paternal care [ATAC-Seq] August 18, 2025
  Contributors : Jason Keagy ; Alison M BellSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Gasterosteus aculeatusOffspring are often influenced by the care they receive from their parents. However, we know little about the underlying neurogenomic mechanisms. Using a half-sib design, threespine stickleback fish were eit […]
• GSE305413 GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate-reporting mice August 18, 2025
  Contributors : Javad Rasouli ; Gholamreza Azizi ; Michael GonzalezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe current study tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, both under steady-state conditions and during autoimmune inflammation of the central nervous system […]
• GSE305414 Campylobacter hepaticus transcriptomics revealed the genes involved in the Spotty Liver Disease (SLD) pathogenesis August 18, 2025
  Contributors : Varsha Bommineni ; Lekshmi K Edison ; Chaitanya Gottapu ; Gary D Butcher ; Subhashinie KariyawasamSeries Type : Expression profiling by high throughput sequencingOrganism : Campylobacter hepaticusCampylobacter hepaticus, the causative agent of spotty liver disease (SLD) in commercial layer hens, leads to liver necrosis, reduced egg production, […]
• GSE202148 A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization August 18, 2025
  Contributors : Yuanyong Huang ; Quanlong Jiang ; Jing-Dong J Han ; Jiemin WongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo delineate the relationship between G2E3-catalyzed H3K14ub and H3K9me3 in genome-wide, we performed chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) […]
• GSE304252 Synergistic effects of Ret coding and enhancer loss-of-function alleles cause progressive loss of inhibitory motor neurons in the enteric nervous system August 18, 2025
  Contributor : Sumantra ChatterjeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHirschsprung disease (HSCR) is a congenital enteric neuropathy caused by disrupted migration, proliferation, or differentiation of enteric neural crest-derived cells (ENCDCs), with pathogenic variants at the RET locus accounting for a major […]