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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE285149 Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set4] June 18, 2026Contributors : Sara G Pelaz ; Katsu Mitsui ; Fuying Gao ; Riki Kawaguchi ; Bal KhakhSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusAstrocytes tile the central nervous system (CNS) and have fundamental roles in physiology and disease, yet there remain open questions about their contributions to physiological and […]
- GSE300281 Transcriptional profiling of AGPS knockout breast cancer cells treated with TGF-B June 18, 2026Contributor : Henry WhitneySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the transcriptional changes associated with depleting ether lipids via AGPS (alkylglycerone phosphate synthase) knockout in epithelial PyMT-1099 murine breast cancer cells. RNA-Seq was performed to compare the gene express […]
- GSE299182 USP43 promotes gemcitabine resistance by regulating cholesterol homeostasis through E2F1 stabilization in bladder cancer June 18, 2026Contributors : Mingxing Li ; Tianyun Liu ; Yu Xiao ; Xinghuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGemcitabine (GEM) serves as a foundational therapy for bladder cancer (BLCA), but chemoresistance significantly limits its therapeutic efficacy. Elucidating the molecular mechanisms underlying this resistanc […]
- GSE302889 Metabolic reprogramming drives pancreatic β cell neogenesis from α cells [RNA-Seq 2] June 18, 2026Contributor : Yufeng ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of functional β cells is a hallmark of diabetes, and restoring β cell mass remains a critical goal in the quest for a specific therapy. One potential strategy is to convert non-β cells in the islet, such as α cells, into insulin-producing cel […]
- GSE302786 Metabolic reprogramming drives pancreatic β cell neogenesis from α cells [RNA-Seq] June 18, 2026Contributor : Guangxing LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of functional β cells is a hallmark of diabetes, and restoring β cell mass remains a critical goal in the quest for a specific therapy. One potential strategy is to convert non-β cells in the islet, such as α cells, into insulin-producing cel […]
- GSE282669 Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a neurons [multiome_scATAC-seq] June 18, 2026Contributors : Faranak Fattahi ; Nicholas ElderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn development, early regionalization steps segregate populations of cells and direct them to specific cell fates. In some instances, this process separates populations of progenitors which eventually become anal […]
- GSE335694 Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation. [CUT&Tag E8.5] June 18, 2026Contributors : Bernard van der Veer ; Kian KohSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMaternal dietary insufficiencies can reshape the offspring epigenome during gestation, contributing to birth defects and developmental disorders. Vitamin C (VitC) is a critical co-factor for Ten-Eleven-Translocati […]
- GSE328949 Glycine Receptor α2 Mediates Endothelium-dependent Vasodilation via Activation of eNOS Signaling June 18, 2026Contributors : Xueya Bai ; Xudong Zhu ; Qi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Endothelium-derived nitric oxide (NO) is an important vasodilator essential for maintaining vascular homeostasis. However, how endothelial NO synthase (eNOS) is regulated in hypertension conditions is not yet fully […]
- GSE328808 Alpha Protein Kinase 3 Gene Therapy Restores Heart Function in Mouse and Human Models of Cardiomyopathy June 18, 2026Contributors : Enzo Porrello ; Neda Rahmani Mehdiabadi ; James McNamaraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere, we generated single-nucleus RNA sequencing (snRNA-seq) data from hiPSC-derived cardiac monolayers carrying TTN heterozygous (TTNhet) and TTN homozygous (TTNhom) truncating variant, alongside their […]
- GSE330857 Signaling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos June 18, 2026Contributors : Daniela Lopes Cardoso ; Marilena Loizou ; Danai D Fourla ; Charles Woodman ; Matthew J Guille ; Colin R SharpeSeries Type : Expression profiling by high throughput sequencingOrganism : Xenopus laevisRetinoic acid, acting through RAR/RXR nuclear receptors, is required for neuronal differentiation in Xenopus laevis. Bexarotene, characterised as […]
- GSE330200 The p.Ser143Pro lamin A/C mutation leads to dilated cardiomyopathy and activates the unfolded protein response pathway in a knock-in mouse model June 18, 2026Contributors : Fanny Lindholm ; Gun West ; Laura Virtanen ; Laura Kähäri ; Mia Ståhle ; Wail Elnammas ; Carl-Gustaf Stenvall ; Maria Liivrand ; Fu-Ping Zhang ; Petra Sipilä ; Maria Gardberg ; Diana Toivola ; Marko Salmi ; Antti Saraste ; Petteri Rinne ; Pekka TaimenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus […]
- GSE335568 The FGF4–integrin β1 axis orchestrates diabetic wound regeneration by restoring directional collective motility. June 18, 2026Contributors : Jian Sun ; Zhifeng Huang ; Jie Zhou ; Shuodan Ding ; Zhiming ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis dataset was generated to investigate the mechanisms underlying the pro-healing effects of Fibroblast Growth Factor 4 (FGF4) on diabetic wounds. We performed RNA sequencing o […]
- GSE335600 Microaerobic Copper Stress Redirects Pyruvate Metabolism and Reveals a CopL-linked Nitrogen Response in Staphylococcus aureus. June 18, 2026Contributors : Sean C Brennan ; Inderpreet Kaur ; Daniella Spencer ; Jo Purves ; Hannah R Sampson ; Julian M Ketley ; Joan A Geoghegan ; Peter W Andrew ; Kevin J Waldron ; Julie A MorrisseySeries Type : Expression profiling by high throughput sequencingOrganism : Staphylococcus aureusCopper is both an essential enzyme cofactor and an antimicrobial agent depl […]
- GSE335660 Hypoxia-preconditioned tendon stem cell-derived extracellular vesicles promote tendon regeneration by modulating macrophage heterogeneity June 18, 2026Contributors : Mingzhao Zhang ; Chenfeng HeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTendon injuries result in poor healing outcomes and functional impairment. Extracellular vesicles (EVs) derived from tendon stem cells (TSCs) have shown therapeutic potential for tendon regeneration. Because tendon tissues exist i […]
- GSE285147 Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set2] June 18, 2026Contributors : Sara G Pelaz ; Katsu Mitsui ; Fuying Gao ; Riki Kawaguchi ; Bal KhakhSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusAstrocytes tile the central nervous system (CNS) and have fundamental roles in physiology and disease, yet there remain open questions about their contributions to physiological and […]