Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE216379 RNA-seq study of a helicon peptide targeting β-Catenin/TCF transcription factor [in vitro] October 21, 2025
  Contributors : YaGuang Si ; Peicheng Du ; Erica VisnessSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenetic and epigenetic alterations in the Wnt signaling pathway leading to constitutive activation of the driver oncogene β-catenin occur in at least 20% of all human cancers. Pharmacologic suppression of aberrant β-ca […]
• GSE264562 Immunoresponsive gene 1 like/itaconate axis promotes neuromast size via metabolic reprogramming to induce Yap signaling October 21, 2025
  Contributors : Rui-jun Shi ; Yu-Qing Xiang ; Xin Wang ; Dong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe organ size control and tissue homeostasis maintenance are vital in the formation of vertebrate sensory organs, which are tightly regulated. Here, we identify a metabolic regulatory axis, Irg1l, a zebrafish […]
• GSE226260 Persistent Activation of Chronic Inflammatory Pathways in Long Covid October 21, 2025
  Contributors : Malika Aid ; Dan H BarouchSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLong Covid, or Post-Acute Sequelae of COVID-19 (PASC), involves a spectrum of chronic symptoms following resolution of acute SARS-CoV-2 infection. Current hypotheses for the pathogenesis of Long Covid include persistent SARS-CoV-2, […]
• GSE266609 A unified workflow to define multipotent progenitor hierarchies October 21, 2025
  Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE266523 A unified workflow to define multipotent progenitor hierarchies (HIVE) October 21, 2025
  Contributors : Kyle Ferchen ; Xuan Zhang ; Nathan Salomonis ; H L GrimesSeries Type : OtherOrganism : Mus musculusMultipotent hematopoietic progenitors with coherent developmental transcriptional programs are defined by their ability to give rise to distinct cell lineages. While the identification of multilineage progenitors is aided by single-cell technolog […]
• GSE279599 SS-31 Ameliorates DSS-Induced Colitis Through Mitochondrial Protection, Gene Regulation and Gut Microbiota Modulation October 21, 2025
  Contributors : Keqi Yu ; Lu Ye ; Shengtao Liao ; Chuanfei Li ; Ke Zhan ; Zhechuan Mei ; Lin LvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the efficacy of SS-31 in alleviating DSS-induced colitis in mice and clarified its potential mechanism through transcriptome sequencing. DSS was used to in […]
• GSE273719 FOCAS: A Comprehensive Transcriptome-Wide Screening Method for Functional m6A Sites [RNA-Seq] October 21, 2025
  Contributors : Xinning Zhang ; Yifan Zhang ; Xinyu Liu ; Jun LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile N6-methyladenosine (m6A) is a widespread RNA modification with profound vital roles, functional dissection of individual m6A sites remains challenging limitated by conventional approaches. To address thi […]
• GSE303983 Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers October 21, 2025
  Contributors : Cheehoon Ahn ; Tao Zhang ; Thomas Rode ; Gayoung Yang ; Olivia K Chugh ; Sierra Ellis ; Sophia J Ghayur ; Shirya Mehta ; Ryan Salzman ; Hui Jiang ; Stephen C Parker ; Charles F Burant ; Jeffrey F HorowitzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe primary aim of this study was to compare the acute […]
• GSE302263 FOCAS: A Comprehensive Transcriptome-Wide Screening Method for Functional m6A Sites [CRISPR screening] October 21, 2025
  Contributors : Xinning Zhang ; Yifan Zhang ; Xinyu Liu ; Jun LiuSeries Type : OtherOrganism : Homo sapiensWhile N6-methyladenosine (m6A) is a widespread RNA modification with profound vital roles, functional dissection of individual m6A sites remains challenging limitated by conventional approaches. To address this gap, we developed FOCAS, a CRISPR-dCas13b-b […]
• GSE305547 Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration October 21, 2025
  Contributors : Cohen Jarish ; Rosenblum MichaelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have employed a fixed single nuclear RNA sequencing using the 10X Genomics FLEX assay to characterize the cellular constituents in healthy human scalp skin. Hair follicles are microanatomic niches that attract immune cells. […]
• GSE304130 Transcriptomics of mouse oligodendrocyte precursor cells treated with microglia-derived extracellular vesicles October 21, 2025
  Contributors : Stefano Raffaele ; Claudia Verderio ; Marta FumagalliSeries Type : Expression profiling by arrayOrganism : Mus musculusMyelin loss due to oligodendrocyte degeneration is a central feature of various neurodegenerative disorders and contributes significantly to neurological disability. Promoting endogenous myelin repair by enhancing oligodendroc […]
• GSE305973 GDF-11 stimulates human extravillous trophoblast cell invasion by upregulating ANGPTL4 expression October 21, 2025
  Contributors : Ze Wu ; Lanlan Fang ; Xuan Dang ; Yiping Yu ; Beibei Bi ; Xiaoyu Han ; Ying-Pu Sun ; Jung-Chien ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProper regulation of extravillous trophoblast (EVT) cell invasion is critical for normal placental development and function. Growth differentiation factor 11 […]
• GSE306386 BRMS1L promotes chemotherapy sensitivity by inhibiting autophagy in breast cancer October 21, 2025
  Contributors : Yuan Li ; Dian Zhang ; Junhao Zhao ; Mei Yang ; Yiping Wang ; Peiyao Lee ; Shaohua QuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBRMS1L (Breast cancer metastasis suppressor 1 like), a component of Sin3A-histone deacetylase (HDAC) co-repressor complex, has been shown to provide an epigenetic regulation […]
• GSE307115 PyBo-seq of IVT RNA October 21, 2025
  Contributors : Jasmin A. Dehnen ; Alexandr V. Gopanenko ; Carola Scholz ; Michael U. Musheev ; Christof NiehrsSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe RNA modification 5-formylcytidine (f5C) is poorly explored in mammals. Low f5C levels reported in mRNA may reflect spurious 5-methylcytidine (m5C) oxid […]
• GSE308002 HTGTS-TCR-seq for profiling of mouse and human T-cell receptor α and β gene rearrangements and diversity October 21, 2025
  Series Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.