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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE304685 ASNA1 CKO with XMCL-CRE+ E14.5 mouse heart RNAseq August 10, 2025Contributors : Zengming Zhang ; Ju ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusASNA1 (also known as TRC40) is a key component of the tail-anchored (TA) protein targeting pathway. To investigate its role in the heart, we generated cardiomyocyte-specific ASNA1 conditional knockout (ASNA1 CKO) mice. RNA-seq analysi […]
- GSE69641 Gene expression in Ramos human B cell line induced by treatment with anti-FCRL1 antibody treatment August 10, 2025Contributors : Satoshi Nagata ; Tomoko IseSeries Type : Expression profiling by arrayOrganism : Homo sapiensB cell receptor CD40 and FCRL1 are highly expressed in Ramos B cell line. Therefore, these receptors are considered to cooperate in B cell activation. In this study, we compared gene expression profiles induced in Ramos cell line by combined treatments […]
- GSE67794 Gene expression in CD30+ L540 cell line induced by different anti-CD30 antibodies that bind to different epitopes August 10, 2025Contributors : Satoshi Nagata ; Tomoko IseSeries Type : Expression profiling by arrayOrganism : Homo sapiensCD30 receptor (TNFRSF8) is highly expressed in some types of lymphoma. Therefore, CD30 is successfully used as a target for antibody-drug conjugate to treat CD30+ lymphoma. In this study, we compared gene expression profiles induced in CD30+ L540 cell […]
- GSE227260 Bronchial epithelial cells transcriptomics upon flagellin stimulation (Microarray) August 10, 2025Contributors : Jeanne Bigot ; Rachel Legendre ; Juliette Hamroune ; Sébastien Jacques ; Mathieu Legars ; Loïc Guillot ; Harriet Corvol ; Christophe Hennequin ; Juliette Guitard ; Viviane Balloy ; Claudia ChicaSeries Type : Expression profiling by arrayOrganism : Homo sapiensInnate immune memory is a new concept describing ability of innate myeloid and lympho […]
- GSE190231 Assessing the impact of TET2 and TET3 deletion in TCRa and TCRb expression and repertoire in murine CD4 T cells in physiological and pathological conditions August 10, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE273802 Differential expression profiles of RNAs in Hep3B cells after silencing LINC01547 August 10, 2025Contributors : Defang Li ; Dan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe extracted the total RNA of Hep3B cells after silencing LINC01547 for 48 h and used RNA-seq technology to detect differentially expressed RNAs in Hep3B cells.
- GSE264485 Ribosome biogenesis in embryo-like grand states as potential therapeutic target for KRAS mutant CRC August 10, 2025Contributor : Ryoji YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKRAS signaling is a promising target for cancer treatment, and the development of molecular targeted therapies has significantly improved the treatment outcome. However, cancer cells often adopt drug tolerant state to impede efficacy of chemotherapeu […]
- GSE302807 Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in Enterococcus faecium August 10, 2025Contributors : Adeline Supandy ; Emma G Mills ; Kyong T Fam ; Ryan K Shields ; Howard C Hang ; Daria Van TyneSeries Type : Expression profiling by high throughput sequencingOrganism : Enterococcus faeciumEnterococcus faecium is a member of the human gut microbiota that has evolved to be a problematic nosocomial pathogen and a leading cause of bloodstream inf […]
- GSE302330 Gene expression effects of KDAC8 (HDAC8) knockout in HT1080 cells August 10, 2025Contributors : Tasha B Toro ; Terry J WattSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the gene expression and phenotype roles of KDAC8, CRISPR/Cas9 was used to create knockout cell lines from wild-type HT1080 cells. Four individual isolated knockout clones were pooled to create the line. Comparable wild-typ […]
- GSE304451 Genome-wide identification of HexA binding sites in Pectobacterium carotovorum PCC27 using ChIP-seq August 10, 2025Contributors : Eunhye Goo ; Jae Hoon LeeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Pectobacterium carotovorumHexA is a global transcriptional regulator involved in quorum sensing and virulence regulation in Pectobacterium carotovorum PCC27. To identify genome-wide DNA binding sites of HexA, we performed chromatin […]
- GSE303728 Facial vein collection and ibuprofen administration in mouse serial blood collections reduce pain and inflammation August 10, 2025Contributors : Jeong-Hwan Yoon ; Moon-Seok Yoon ; Eunjin Bae ; Jin Soo HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBlood collection is essential for assessing the physiological status of laboratory animals, however, it inflicts pain, stress, tissue damage, and behavioral disorder to the animal. The administration […]
- GSE304572 Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer August 10, 2025Contributors : Christoph Kahlert ; Ulf D KahlertSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensPancreatic cancer (PC) is a highly lethal malignancy, and its early diagnosis remains a clinical challenge. Extracellular vesicles (EVs) derived from patient plasma contain diverse RNA species that may serve as minimally […]
- GSE304627 Transcriptomic analysis of HexA-regulated gene expression in Pectobacterium carotovorum during different growth phases August 10, 2025Contributors : Eunhye Goo ; Jae Hoon LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Pectobacterium carotovorumHexA is a global transcriptional regulator involved in the modulation of virulence and environmental adaptation in Pectobacterium carotovorum. To identify the genes regulated by HexA, we performed RNA-seq analysis compa […]
- GSE304634 RNAseq data of liver macrophages in YFP positive and YPF negative August 10, 2025Contributors : Tong Lei ; Qian Zhang ; Zhaoqi Zhang ; Yong ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages (RTMs), predominantly originating from embryonic progenitors, play a pivotal role in maintaining tissue homeostasis and immune regulation. Their functional diversity is shaped by bot […]
- GSE276582 Assessing the impact of TET2 and TET3 deletion in TCRa and TCRb expression and repertoire in murine CD4 T cells in physiological and pathological conditions [TCR-seq] August 10, 2025Contributors : Tarmo Äijö ; Ageliki TsagaratouSeries Type : OtherOrganism : Mus musculusTET proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation and to regulate gene expression. Notably, TET2 is one of the most frequently mutated genes in hematological malignanc […]