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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE314038 Muco-Obstructive Lung Disease Exhibits Distinct Hypoxic and Inflammatory Airway Epithelial Gene Pathways August 17, 2026Contributors : Yu Mikami ; Ella Burns ; Hong Dang ; Catharina van Heusden ; Ray A Caldwell ; Boris Reidel ; Minako Furusho ; Hiroaki Murano ; Carla M Ribeiro ; Mehmet Kesimer ; Takanori Asakura ; Martina Gentzsch ; Kenichi Okuda ; Scott H Randell ; Wanda K O'Neal ; Richard C BoucherSeries Type : Expression profiling by high throughput sequencingOrganism […]
- GSE311577 A novel role for transcription factor NFE2 in regulating redox responses and chemotherapy resistance in acute myeloid leukemia [RNA-seq] August 17, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusElevated activity of transcription factor NFE2 is sufficient to cause leukemic transformation in absence of a classical leukemic driver. However, the molecular mechanism promoting NFE2-driven leukemogenesis is not known. Here we report a previously unrecognized role for NF […]
- GSE325203 Engineering epicardium-integrated human iPSC-derived heart tissue for modelling Hutchinson-Gilford Progeria Syndrome August 17, 2026Contributors : Martta Häkli ; Amanda Putri Elvandari ; Yasuko Matsumura ; Shunsuke Funakoshi ; Antonio Lucena-Cacace ; Yoshinori YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEngineered heart tissues (EHT) have been utilized in research for almost three decades and have become an important tool in cardiovascula […]
- GSE320239 Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3 [RNA-Seq] August 17, 2026Contributors : Nazli Akilli ; Paul-Swann Puel ; Marco Di Stefano ; Fernando Muzzopappa ; Lauriane Fritsch ; Fabian Erdel ; Daniel Jost ; Thierry Cheutin ; Giacomo CavalliSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterPolycomb Repressive Complex 1 (PRC1) forms nuclear condensates that organize target chromati […]
- GSE280228 The E3 ubiquitin ligase Hectd3 controls immune colonic inflammation by restricting Myd88 signaling August 17, 2026Contributors : Shamima Islam ; Shahnewaj Mannan ; Ashley Zuniga ; Upasana Parthasarathy ; Tomas Zelenka ; Timothy I Shaw ; Dorina AvramSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUbiquitination is an important post-translational modification associated with essential cellular processes and implicated in regulation o […]
- GSE239309 Oncogenic KRAS promotes pancreatic ductal adenocarcinoma (PDAC) through post-transcriptionally regulated KRAS-induced granules (KGs) [miRNA-seq] August 17, 2026Contributors : Zoey Ziyue Yang ; Mara Cardenas ; Angelina BortolettoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusOver 90% of pancreatic ductal adenocarcinoma (PDAC) tumors harbor mutations in KRAS which promote many hallmark characteristics of cancer. How a single driver mutation causes the maligna […]
- GSE343618 Evaluation of extracellular microRNAs as potential biomarker candidates for assessing chlamydia reinfection risk August 17, 2026Contributors : William M Geisler ; Chloe MeewesSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe profiled extracellualr miRNAs derived from extracellular vessicles (EV) and whole serum collected from a cohort of women to identify potential miRNA bioamrkers that could be used to predict chlamydia reinfection risk.
- GSE287765 Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin [scEdU-seq] August 17, 2026Contributors : R. Ciaran M Frater ; Rikke Rejnholdt Jensen ; Joaquim Ollé López ; Valentin Flury ; Jeroen van den Berg ; Jonathan Humbert ; Anton Bournonville ; Nicolas Alcaraz ; Simai Wang ; Hannah J Richter ; Marty G Yang ; Qian Du ; Alexander van Oudenaarden ; Vijay Ramani ; Nils Krietenstein ; Anja GrothSeries Type : OtherOrganism : Mus musculusNucleosom […]
- GSE343732 Native American ancestry-enriched eQTLs regulate HER2 amplicon genes and are associated with breast cancer outcomes in Colombian women August 17, 2026Contributors : Laura Rey-Vargas ; Lina Maria Bejarano-Rivera ; Yina T Zambrano ; Wendy Montero-Ovalle ; Carlos A Huertas-Caro ; Patricia Lopez-Correa ; Reggie Garcia-Robles ; I King Jordan ; Silvia J Serrano-Gomez ; Diego Felipe Ballen-LozanoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWomen with higher Native Americ […]
- GSE343650 177Lu-labeled DOTA-EB-RGD as a Candidate for Thyroid Cancer Therapy August 17, 2026Contributors : Sonam Kumari ; Joanna Klubo-GwiezdzinskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntegrin αVβ3, a transmembrane receptor involved in tumor growth and metastasis, specifically recognizes and binds proteins with the arginylglycylaspartyl (RGD) peptide sequence. Using mRNA and/or protein expression da […]
- GSE343811 Microsatellite-stable colorectal tumor-derived SEMA3A drives CD8⁺ T cell senescence and immunotherapy resistance via TCF1 repression August 17, 2026Contributor : Huihui YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicrosatellite-stable (MSS) colorectal cancers (CRC) display inherent insensitivity to immune checkpoint blockade, and the pivotal mechanisms responsible for this immunotherapeutic resistance have not been fully clarified. Here, we demonstrate that […]
- GSE343843 A developmental atlas of human fetal γδ T cells across tissues during the second and third trimesters of gestation August 17, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE343885 Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease August 17, 2026Contributors : Divyesh Joshi ; Raja Chakraborty ; Oleksii S Rukhlenko ; Anna Tuliakova ; Zhongwei Sun ; Tejas Bhogale ; Jessica Furtado ; Hanqiang Deng ; James G Traylor Jr. ; Hiroaki Imoto ; Anthony Wayne Orr ; George Tellides ; Kathleen A Martin ; Boris N Kholodenko ; Martin A SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism […]
- GSE305949 Lysosomal Stress and Mitochondrial Dysfunction Define the Cellular Response to Photoactivated 1,9-Dimethyl-Methylene Blue August 17, 2026Contributors : Marcia Franco ; Felipe Ravagnani ; Suely Marie ; Sueli Oba-Shinjo ; Leonardo Assis ; Mauricio BaptistaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPhotodynamic therapy (PDT) using 1,9-dimethyl methylene blue (DMMB) induces coordinated mitochondrial and lysosomal damage and results in strong cellular de […]
- GSE343610 MACF1 Promotes Colorectal Cancer Progression via ATF4-Mediated ASNS Regulation August 17, 2026Contributors : Xiaoying Wang ; Zhen Han ; Xiang Gao ; Qindan Du ; Jingjie Shen ; Yong Zhao ; Yixin Bian ; Junjie WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Microtubule-actin cross-linking factor 1 (MACF1) is a cytoskeletal cross-linker implicated in cancer pathogenesis, yet its role in colorectal canc […]